Works (2)
Updated: July 5th, 2023 16:01
2000 journal article
Effect of an intravitreal cyclosporine implant on experimental uveitis in horses
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 239–255.
author keywords: uveitis; cyclosporine; intravitreal; equine; experimental
MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / immunology; Aqueous Humor / metabolism; Cyclosporine / administration & dosage; Cyclosporine / immunology; Cyclosporine / pharmacokinetics; Drug Implants; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / immunology; Immunosuppressive Agents / pharmacokinetics; Interferon-gamma / biosynthesis; Interferon-gamma / metabolism; Interleukin-2 / biosynthesis; Interleukin-2 / metabolism; Lymphocyte Count / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
TL;DR:
CsA implants did not completely eliminate the development of a second ('recurrent') experimental inflammatory episode in these horses, but the duration and severity of inflammation, cellular infiltration, tissue destruction, and pro-inflammatory cytokines RNA transcript levels were significantly less in those eyes implanted with the CsA device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Long-term effect on the equine eye of an intravitreal device used for sustained release of cyclosporine A
Veterinary Ophthalmology, 3(2), 105.
TL;DR:
The CsA devices were well tolerated with no long-term complications from the implants themselves, however, complications may occur from inadvertent implantation trauma or contamination during surgery.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
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