2000 journal article

Effect of an intravitreal cyclosporine implant on experimental uveitis in horses


By: B. Gilger n, E. Malok n, T. Stewart n, D. Horohov*, P. Ashton, T. Smith, G. Jaffe*, J. Allen n

author keywords: uveitis; cyclosporine; intravitreal; equine; experimental
MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / immunology; Aqueous Humor / metabolism; Cyclosporine / administration & dosage; Cyclosporine / immunology; Cyclosporine / pharmacokinetics; Drug Implants; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / immunology; Immunosuppressive Agents / pharmacokinetics; Interferon-gamma / biosynthesis; Interferon-gamma / metabolism; Interleukin-2 / biosynthesis; Interleukin-2 / metabolism; Lymphocyte Count / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
TL;DR: CsA implants did not completely eliminate the development of a second ('recurrent') experimental inflammatory episode in these horses, but the duration and severity of inflammation, cellular infiltration, tissue destruction, and pro-inflammatory cytokines RNA transcript levels were significantly less in those eyes implanted with the CsA device. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Long-term effect on the equine eye of an intravitreal device used for sustained release of cyclosporine A

Veterinary Ophthalmology, 3(2), 105.

By: B. Gilger n, E. Malok*, T. Stewart*, P. Ashton, T. Smith, G. Jaffe, J. Allen*

TL;DR: The CsA devices were well tolerated with no long-term complications from the implants themselves, however, complications may occur from inadvertent implantation trauma or contamination during surgery. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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