Works (2)
Updated: July 5th, 2023 16:02
2000 journal article
Reduction of diepoxybutane-induced sister chromatid exchanges by glutathione peroxidase and erythrocytes in transgenic Big Blue (R) mouse and rat fibroblasts
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 447(2), 267–274.
author keywords: Big Blue (R); SCE; diepoxybutane; detoxification
MeSH headings : Animals; Cells, Cultured; Cytogenetic Analysis; Dose-Response Relationship, Drug; Epoxy Compounds / adverse effects; Erythrocytes / physiology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Peroxidase / pharmacology; Male; Mice; Mice, Transgenic; Mitotic Index / drug effects; Mutagens / adverse effects; Rats; Sister Chromatid Exchange / drug effects
TL;DR:
GSH-Px may be important in the detoxification of DEB-induced DNA damage that results in the formation of SCEs, according to the observed differences in the rodent carcinogenic response to BD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Characterization of new transgenic Big Blue((R)) mouse and rat primary fibroblast cell strains for use in molecular toxicology studies
Environmental and Molecular Mutagenesis, 34(2-3), 90–96.
Source: NC State University Libraries
Added: August 6, 2018
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