@article{baeumer_stahl_sander_petersen_paps_stark_kietzmann_olivry_2011, title={Lack of preventing effect of systemically and topically administered histamine H-1 or H-4 receptor antagonists in a dog model of acute atopic dermatitis}, volume={20}, ISSN={["0906-6705"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79959528878&partnerID=MN8TOARS}, DOI={10.1111/j.1600-0625.2011.01268.x}, abstractNote={As there is evidence for an anti-inflammatory efficacy of histamine H4 receptor (H4R) selective antagonists, we aimed at testing the efficacy of the H4R antagonists JNJ7777120 and JNJ28307474 in comparison with histamine H1 receptor (H1R) antagonists hydroxyzine and cetirizine for skin lesion prevention in a canine model of acute atopic dermatitis. Six atopic Maltese-beagle dogs experimentally sensitized to Dermatophagoides farinae (Df) house dust mites were selected for this study. Twenty-four hours after challenge by epicutaneous application of Df, erythematous skin lesions were scored. In this blinded, placebo and active controlled study, topical JNJ7777120 or JNJ28307474 was applied as a 1% solution before allergen challenge. The latter was also given orally at 15 mg/kg before and after allergen challenge. A 0.015% triamcinolone acetonide solution was used as a positive control. The H1R antagonists hydroxyzine and cetirizine were administered orally before challenge in a second experiment. Twenty-four hours after challenge, placebo-treated animals had a median lesional score of 2. Treatment with topical and oral JNJ28307474 resulted in a median score of 2.5. After topical administration of JNJ7777120, the median lesional score was 2. Hydroxyzine and cetirizine did also not reduce the median score of the placebo treatment. Triamcinolone acetonide prevented all dogs from having any lesions. Determination of histamine in lesions revealed that only during the initiation increased concentrations of histamine were detected. In conclusion, the preventive administration of H1R or H4R antagonists has no impact on the development of acute skin lesions in this experimental canine atopic dermatitis model. Figure S1. Amount of permeated JNJ7777120 (A) and JNJ28307474 (B) in the acceptor medium after topical administration of a 1% formulation on dog skin (mean ± SD of three different skin samples/each experiment). Figure S2. Concentration of histamine in the microdialysate after epicutaneous administration of Df antigen. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.}, number={7}, journal={EXPERIMENTAL DERMATOLOGY}, author={Baeumer, Wolfgang and Stahl, Jessica and Sander, Kerstin and Petersen, Lars J. and Paps, Judy and Stark, Holger and Kietzmann, Manfred and Olivry, Thierry}, year={2011}, month={Jul}, pages={577–581} }
 @article{bauman_kaplan_businger_1997, title={Nowcasting convective activity for space shuttle landings during easterly flow regimes}, volume={12}, DOI={10.1175/1520-0434(1997)012<0078:NCAFSS>2.0.CO;2}, abstractNote={Abstract Space shuttle landings at the shuttle landing facility at Kennedy Space Center are subject to strict weather-related launch commit criteria and flight rules. Complex launch commit criteria and end-of-mission flight rules demand very accurate nowcasts (forecasts of less than 2 h) of cloud, wind, visibility, precipitation, turbulence, and thunderstorms prior to shuttle launches and landings. During easterly flow regimes the onset of convective activity has proven to be particularly difficult to predict. Contrasting weather ranging from clear skies to thunderstorms occurs on days with seemingly similar synoptic environments. Four days of easterly flow during the Convection and Precipitation/Electrification (CaPE) Experiment were investigated in an effort to identify and simulate key features that distinguish convectively active and suppressed conditions. Data from CaPE and operational data, including satellite imagery and National Centers for Environmental Prediction model analysis output over the F...}, number={1}, journal={Weather and Forecasting}, author={Bauman, W. H. and Kaplan, M. L. and Businger, S.}, year={1997}, pages={78–107} }