Jeff Leips

Works (10)

Updated: July 5th, 2023 16:02

2019 journal article

Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 74(12), 1844–1852.

By: M. Gabrawy*, S. Campbell*, M. Carbone n, T. Morozova n, G. Arya n, L. Turlapati n, J. Walston *, M. Starz-Gaiano * ...

author keywords: Angiotensin; Aging; Locomotion; Muscle; Genetic variation
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Genotype; Lisinopril / pharmacology; Longevity / drug effects; Male; Peptidyl-Dipeptidase A / metabolism; Phenotype; Transcriptome
TL;DR: It is demonstrated that skeletal muscle-specific Ance, the Drosophila ortholog of ACE, is involved in physical decline and genetic variation in phenotypic responses to an ACE inhibitor is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 30, 2019

2007 journal article

Speed-mapping quantitative trait loci using microarrays

NATURE METHODS, 4(10), 839–841.

By: C. Lai*, J. Leips n, W. Zou n, J. Roberts*, K. Wollenberg *, L. Parnell *, Z. Zeng n, J. Ordovas *, T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Female; Gene Expression Profiling / methods; Longevity / genetics; Male; Oligonucleotide Array Sequence Analysis / methods; Polymorphism, Genetic / genetics; Quantitative Trait Loci
TL;DR: A rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Phenotypic variation and natural selection at Catsup, a pleiotropic quantitative trait gene in Drosphila

CURRENT BIOLOGY, 16(9), 912–919.

By: M. Carbone n, K. Jordan n, R. Lyman n, S. Harbison  n, J. Leips*, T. Morgan n, M. DeLuca n, P. Awadalla n, T. Mackay n

MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 review

Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster

[Review of ]. GENETICS, 172(3), 1595–1605.

By: J. Leips n, P. Gilligan n & T. Mackay  n

MeSH headings : Aging / genetics; Aging / physiology; Animals; Animals, Inbred Strains; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic / physiology; Female; Fertility / genetics; Genetic Markers; Genetic Variation / physiology; Male; Quantitative Trait Loci
TL;DR: The results suggest that different loci contribute to the variation in fecundity as the organism ages, and provide support for the mutation accumulation theory of aging as applied to reproductive senescence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

The complex genetic architecture of Drosophila life span

EXPERIMENTAL AGING RESEARCH, 28(4), 361–390.

By: J. Leips n & T. Mackay  n

MeSH headings : Animals; Chimera; Crosses, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Quantitative Trait Loci; Sexual Behavior, Animal
TL;DR: All of the QTL mapping data for Drosophila life span is summarized, the additive allelic effects and dominance of QTL were highly sex-specific, and future prospects for disentangling the genetic and environmental influences on this trait are outlined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

The suitability of calcein to mark poeciliid fish and a new method of detection

TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY, 130(3), 501–507.

By: J. Leips n, C. Baril n, F. Rodd *, D. Reznick *, F. Bashey *, G. Visser n, J. Travis *

TL;DR: The effects of calcein on survival, growth, and the timing and size at sexual maturity of least killifish Heterandria formosa are examined and a new method for detecting Calcein is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Genetic influences on experimental population dynamics of the least killifish

ECOLOGICAL MONOGRAPHS, 70(2), 289–309.

By: J. Leips*, J. Travis * & F. Rodd*

author keywords: demography; genetic differentiation; Heterandria formosa; life history; offspring number; offspring size; trade-off; plasticity; Poeciliidae; population dynamics
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Quantitative trait loci for life span in Drosophila melanogaster: Interactions with genetic background and larval density

Genetics, 155(4), 1773–1788.

By: J. Leips & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Response of treefrog larvae to drying ponds: comparing temporary and permanent pond breeders

Ecology (Brooklyn, New York, N.Y.), 81(11), 2997–3008.

By: J. Leips, M. McManus & J. Travis

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

The comparative expression of life-history traits and its relationship to the numerical dynamics of four populations of the least killifish

JOURNAL OF ANIMAL ECOLOGY, 68(3), 595–616.

By: J. Leips n & J. Travis *

author keywords: body size; community composition; demography; density dependence; life-history variation; poeciliid fish; population dynamics
TL;DR: The effects of density on female body size are the major avenue for negative feedback of population density on the subsequent dynamics through life-history expression, and if the variation in offspring size among populations is adaptive, it may be a prominent example of density-dependent life- history evolution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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