@article{gabrawy_campbell_carbone_morozova_arya_turlapati_walston_starz-gaiano_everett_mackay_et al._2019, title={Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster}, volume={74}, ISSN={["1758-535X"]}, DOI={10.1093/gerona/glz152}, abstractNote={Abstract}, number={12}, journal={JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES}, author={Gabrawy, Mariann M. and Campbell, Sarah and Carbone, Mary Anna and Morozova, Tatiana V and Arya, Gunjan H. and Turlapati, Lavanya B. and Walston, Jeremy D. and Starz-Gaiano, Michelle and Everett, Logan and Mackay, Trudy F. C. and et al.}, year={2019}, month={Dec}, pages={1844–1852} }
 @article{lai_leips_zou_roberts_wollenberg_parnell_zeng_ordovas_mackay_2007, title={Speed-mapping quantitative trait loci using microarrays}, volume={4}, ISSN={["1548-7105"]}, DOI={10.1038/NMETH1084}, abstractNote={We developed a rapid, economical method for high-resolution quantitative trait locus (QTL) mapping using microarrays for selective genotyping of pooled DNA samples. We generated 21,207 F2 flies from two inbred Drosophila melanogaster strains with known QTLs affecting lifespan, and hybridized DNA pools of young and old flies to microarrays. We used changes of gene frequency of 2,326 single-feature polymorphisms (SFPs) to map previously identified and additional QTLs affecting lifespan.}, number={10}, journal={NATURE METHODS}, author={Lai, Chao-Qiang and Leips, Jeff and Zou, Wei and Roberts, Jessica F. and Wollenberg, Kurt R. and Parnell, Laurence D. and Zeng, Zhao-Bang and Ordovas, Jose M. and Mackay, Trudy F. C.}, year={2007}, month={Oct}, pages={839–841} }
 @article{carbone_jordan_lyman_harbison_leips_morgan_deluca_awadalla_mackay_2006, title={Phenotypic variation and natural selection at Catsup, a pleiotropic quantitative trait gene in Drosphila}, volume={16}, ISSN={["1879-0445"]}, DOI={10.1016/j.cub.2006.03.051}, abstractNote={Quantitative traits are shaped by networks of pleiotropic genes . To understand the mechanisms that maintain genetic variation for quantitative traits in natural populations and to predict responses to artificial and natural selection, we must evaluate pleiotropic effects of underlying quantitative trait genes and define functional allelic variation at the level of quantitative trait nucleotides (QTNs). Catecholamines up (Catsup), which encodes a negative regulator of tyrosine hydroxylase , the rate-limiting step in the synthesis of the neurotransmitter dopamine, is a pleiotropic quantitative trait gene in Drosophila melanogaster. We used association mapping to determine whether the same or different QTNs at Catsup are associated with naturally occurring variation in multiple quantitative traits. We sequenced 169 Catsup alleles from a single population and detected 33 polymorphisms with little linkage disequilibrium (LD). Different molecular polymorphisms in Catsup are independently associated with variation in longevity, locomotor behavior, and sensory bristle number. Most of these polymorphisms are potentially functional variants in protein coding regions, have large effects, and are not common. Thus, Catsup is a pleiotropic quantitative trait gene, but individual QTNs do not have pleiotropic effects. Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms.}, number={9}, journal={CURRENT BIOLOGY}, author={Carbone, Mary Anna and Jordan, Katherine W. and Lyman, Richard F. and Harbison, Susan T. and Leips, Jeff and Morgan, Theodore J. and DeLuca, Maria and Awadalla, Philip and Mackay, Trudy F. C.}, year={2006}, month={May}, pages={912–919} }
 @misc{leips_gilligan_mackay_2006, title={Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster}, volume={172}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.105.048520}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Leips, J and Gilligan, P and Mackay, TFC}, year={2006}, month={Mar}, pages={1595–1605} }
 @article{leips_mackay_2002, title={The complex genetic architecture of Drosophila life span}, volume={28}, ISSN={["1096-4657"]}, DOI={10.1080/03610730290080399}, abstractNote={Continuous phenotypic variation in life span results from segregating genetic variation at multiple loci, the environmental sensitivity of expression of these loci, and the history of environmental variation experienced by the organism throughout its life. We have mapped quantitative trait loci (QTL) that produce variation in the life span of mated Drosophila melanogaster using a panel of recombinant inbred lines (RIL) that were backcrossed to the parental strains from which they were derived. Five QTL were identified that influence mated life span, three were male-specific, one was female-specific, and one affected life span in both sexes. The additive allelic effects and dominance of QTL were highly sex-specific. One pair of QTL also exhibited significant epistatic effects on life span. We summarize all of the QTL mapping data for Drosophila life span, and outline future prospects for disentangling the genetic and environmental influences on this trait.}, number={4}, journal={EXPERIMENTAL AGING RESEARCH}, author={Leips, J and Mackay, TFC}, year={2002}, pages={361–390} }
 @article{leips_baril_rodd_reznick_bashey_visser_travis_2001, title={The suitability of calcein to mark poeciliid fish and a new method of detection}, volume={130}, ISSN={["0002-8487"]}, DOI={10.1577/1548-8659(2001)130<0501:TSOCTM>2.0.CO;2}, abstractNote={Abstract The suitability of calcein as a marker for population studies depends on (1) the assumption that marked individuals have unaltered viability, (2) the fidelity of the calcein label, and (3) the facility with which calcein can be used. We examined the effects of calcein on survival, growth, and the timing and size at sexual maturity of least killifish Heterandria formosa and present a new method for detecting calcein. To test the assumption that marked individuals have unaltered viability, juvenile least killifish were immersed for 24 h in a 250-mg/L solution of calcein. A control group of same-aged juveniles was immersed in the same volume of water for 24 h without calcein. All individuals were then removed and reared individually in separate containers. Upon examination under an epifluorescent microscope, all calcein-treated fish showed fluorescent green marks on their scales and fin rays, whereas controls did not. The calcein treatment had no significant effect on growth and survival through 9 w...}, number={3}, journal={TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY}, author={Leips, J and Baril, CT and Rodd, FH and Reznick, DN and Bashey, F and Visser, GJ and Travis, J}, year={2001}, month={May}, pages={501–507} }
 @article{leips_travis_rodd_2000, title={Genetic influences on experimental population dynamics of the least killifish}, volume={70}, ISSN={["1557-7015"]}, DOI={10.2307/2657178}, abstractNote={When natural populations differ in density or in the dynamic fluctuations of population size, some of those differences may result from their different ecological conditions, and some may originate from genetically based differences in life history expression. Natural populations of the live-bearing poeciliid fish, Heterandria formosa, vary considerably in their population dynamics, with densities that differ between populations by as much as sevenfold. This system offers an excellent opportunity to explore the potential role of genetically based differences in life history expression in creating different dynamic patterns in a common environment. We created five different genetic stocks of H. formosa by carrying out a series of crosses using fish from two North Florida populations (the Wacissa River and Trout Pond) and used them to initiate replicate experimental populations in artificial ponds. The five stocks consisted of two “controls,” which were pure Wacissa River and Trout Pond stocks, and three types of hybrid stocks. The hybrid stocks differed in a regular way in the proportion of genes from one population or the other. The crossing scheme was designed so that each hybrid stock would have the same proportion of heterozygous (or “heterodemic”) loci but would differ in the proportion and/or identity of homozygous (or “homodemic”) loci from the Wacissa River and Trout Pond populations. These populations were chosen because a previous study had found that population densities in the Wacissa River greatly exceeded those of Trout Pond and exhibited a higher range of population fluctuation during the breeding season. We addressed four questions in this experiment: (1) Are there genetically based differences in life history traits of fish from the two populations? (2) If so, do differences in life history expression produce differences in population dynamics in a common environment? (3) Which traits have the greatest influence on population dynamics? (4) How do changes in density affect the phenotypes of individual traits that govern the rates of birth and death in a population? We followed experimental populations of the five genetic stocks from their initiation at low density through 4–6 generations of population growth and decline. The mean offspring size differed among stocks by as much as 50%. At low densities, offspring size exhibited a trade-off with brood size: Trout Pond alleles were associated with more, smaller offspring. At higher densities, offspring sizes were similar among stocks, and the trade-off with offspring number was not evident. Stocks differed in realized population growth rate by as much as 70%; the rank order differences among stocks with respect to population growth rate appeared to match the genetic relatedness among stocks based on the expected percentage of Trout Pond alleles. Differences in population growth rate appeared to be due to differences in brood size among stocks at low density. Stocks did not differ in the equilibrium population size, which indicated the absence of a trade-off between population growth rate and carrying capacity in this environment. Adult survival and recruitment of juveniles into the adult population both declined linearly with increasing density; and stocks did not generally differ in those rates after the effects of density had been taken into account. The stocks differed in their response to the depressant effects of density on life history trait expression. The offspring size of the pure Wacissa River stock was much more sensitive to density than was the offspring size of the pure Trout Pond stock. However, the brood sizes of the Wacissa River stock were reduced much less than those of the Trout Pond stock when exposed to the same high density. These results suggest that life history distinctions among populations, both in the mean values and plasticity of traits, play a role in creating different dynamics. We discuss the ways in which phenotypic plasticity in reproductive traits potentially acts as a mechanism to stabilize population dynamics in this species.}, number={2}, journal={ECOLOGICAL MONOGRAPHS}, author={Leips, J and Travis, J and Rodd, FH}, year={2000}, month={May}, pages={289–309} }
 @article{leips_mackay_2000, title={Quantitative trait loci for life span in Drosophila melanogaster: Interactions with genetic background and larval density}, volume={155}, number={4}, journal={Genetics}, author={Leips, J. and Mackay, T. F. C.}, year={2000}, month={Aug}, pages={1773–1788} }
 @article{leips_mcmanus_travis_2000, title={Response of treefrog larvae to drying ponds: comparing temporary and permanent pond breeders}, volume={81}, number={11}, journal={Ecology (Brooklyn, New York, N.Y.)}, author={Leips, J. and McManus, M. G. and Travis, J.}, year={2000}, pages={2997–3008} }
 @article{leips_travis_1999, title={The comparative expression of life-history traits and its relationship to the numerical dynamics of four populations of the least killifish}, volume={68}, ISSN={["1365-2656"]}, DOI={10.1046/j.1365-2656.1999.00311.x}, abstractNote={1.We examined the numerical dynamics in four natural populations of the least killifish [Heterandria formosaAgassiz (1855)]; to ascertain how those dynamics affected the expression of key life‐history traits and, in turn, whether life‐history variation among populations might be responsible for different dynamic properties. Populations were chosen from two types of communities, spring‐fed rivers and lakes, to examine the relative influence of community characteristics on these relationships.}, number={3}, journal={JOURNAL OF ANIMAL ECOLOGY}, author={Leips, J and Travis, J}, year={1999}, month={May}, pages={595–616} }