Meredith Page Gooding

Works (5)

Updated: July 5th, 2023 16:02

2009 article

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

Sternberg, R. M., Gooding, M. P., Hotchkiss, A. K., & LeBlanc, G. A. (2009, August 3). Ecotoxicology, Vol. 19, pp. 4–23.

By: R. Sternberg n, M. Gooding n, A. Hotchkiss n & G. LeBlanc n 

author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta)

Gooding, M. P., & LeBlanc, G. A. (2004, September 1). Invertebrate Biology, Vol. 123, pp. 237–243.

By: M. Gooding n & G. LeBlanc n 

topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Pharmacological Effects and Assays
TL;DR: This study provides compelling evidence that free testosterone levels in the mud snail are regulated through fatty acid esterification/de-esterification processes and this regulatory function contributes to seasonal fluctuations in freeosterone levels. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 article

The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta).

Gooding, M. P., Wilson, V. S., Folmar, L. C., Marcovich, D. T., & LeBlanc, G. A. (2002, October 22). Environmental Health Perspectives, Vol. 111, pp. 426–430.

By: M. Gooding n, V. Wilson  n, L. Folmar n, D. Marcovich n & G. LeBlanc n 

author keywords: acyltransferase; fatty acid esters; Ilyanassa obsoleta; imposex; invertebrate endocrinology; mud snail; testosterone; tributyltin
MeSH headings : Animals; Disorders of Sex Development / chemically induced; Environmental Exposure; Esters; Fatty Acids / metabolism; Female; Male; Snails / physiology; Testosterone / blood; Testosterone / metabolism; Trialkyltin Compounds / adverse effects
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Animal Ecology and Behavior Studies
TL;DR: Results indicate that TBT elevates free testosterone levels in snails by decreasing the production or retention of testosterone-fatty acid esters, and may be a co-contributor to the testosterone fatty esterification process or a factor in the enhanced hydrolysis of the testosterone- fatty acid pool. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 article

Biotransformation and Disposition of Testosterone in the Eastern Mud Snail Ilyanassa obsoleta

Gooding, M. P., & LeBlanc, G. A. (2001, May 1). General and Comparative Endocrinology, Vol. 122, pp. 172–180.

By: M. Gooding n & G. LeBlanc n 

author keywords: Ilyanassa obsoleta; mud snail; fatty acid conjugates; testosterone; imposex; invertebrate endocrinology; tributyltin
MeSH headings : Acyltransferases / metabolism; Animals; Biotransformation; Chromatography, Thin Layer; Disorders of Sex Development / metabolism; Fatty Acids, Nonesterified / blood; Hydrolysis; Snails / metabolism; Testosterone / pharmacokinetics
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Pesticide and Herbicide Environmental Studies
TL;DR: Results indicate that AP1, which represents over 70% of the testosterone biotransformation products, is a fatty acid ester of testosterone, which might represent a target of TBT toxicity. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

Imposex in Three Marine Gastropod Species in Chile and Potential Impact on Muriciculture

Gooding, M., Gallardo, C., & LeBlanc, G. (1999, December 1). Marine Pollution Bulletin, Vol. 38, pp. 1227–1231.

By: M. Gooding n, C. Gallardo* & G. LeBlanc n 

author keywords: imposex; gastropod; tributyltin; Chile; Chorus giganteus; Nucella
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: Since sex of individuals in muriciculture is determined by the presence or absence of a penis, imposex may lead to erroneous classification of males and females and have a negative impact on sustainable cultivation and harvest of gastropods in Chile. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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