Meredith Page Gooding

Works (5)

Updated: July 5th, 2023 16:02

2009 review

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

[Review of ]. ECOTOXICOLOGY, 19(1), 4–23.

By: R. Sternberg n, M. Gooding, A. Hotchkiss n & G. LeBlanc n 

author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
TL;DR: A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta)

Invertebrate Biology, 123(3), 237–243.

By: M. Gooding n & G. LeBlanc n 

TL;DR: This study provides compelling evidence that free testosterone levels in the mud snail are regulated through fatty acid esterification/de-esterification processes and this regulatory function contributes to seasonal fluctuations in freeosterone levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta)

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(4), 426–430.

By: M. Gooding n, V. Wilson  n, L. Folmar n, D. Marcovich n & G. LeBlanc n 

author keywords: acyltransferase; fatty acid esters; Ilyanassa obsoleta; imposex; invertebrate endocrinology; mud snail; testosterone; tributyltin
MeSH headings : Animals; Disorders of Sex Development / chemically induced; Environmental Exposure; Esters; Fatty Acids / metabolism; Female; Male; Snails / physiology; Testosterone / blood; Testosterone / metabolism; Trialkyltin Compounds / adverse effects
TL;DR: Results indicate that TBT elevates free testosterone levels in snails by decreasing the production or retention of testosterone-fatty acid esters, and may be a co-contributor to the testosterone fatty esterification process or a factor in the enhanced hydrolysis of the testosterone- fatty acid pool. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 122(2), 172–180.

By: M. Gooding n & G. LeBlanc n 

author keywords: Ilyanassa obsoleta; mud snail; fatty acid conjugates; testosterone; imposex; invertebrate endocrinology; tributyltin
MeSH headings : Acyltransferases / metabolism; Animals; Biotransformation; Chromatography, Thin Layer; Disorders of Sex Development / metabolism; Fatty Acids, Nonesterified / blood; Hydrolysis; Snails / metabolism; Testosterone / pharmacokinetics
TL;DR: Results indicate that AP1, which represents over 70% of the testosterone biotransformation products, is a fatty acid ester of testosterone, which might represent a target of TBT toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Imposex in three marine gastropod species in Chile and potential impact on muriciculture

MARINE POLLUTION BULLETIN, 38(12), 1227–1231.

By: M. Gooding n, C. Gallardo* & G. Leblanc n 

author keywords: imposex; gastropod; tributyltin; Chile; Chorus giganteus; Nucella
TL;DR: Since sex of individuals in muriciculture is determined by the presence or absence of a penis, imposex may lead to erroneous classification of males and females and have a negative impact on sustainable cultivation and harvest of gastropods in Chile. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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