Karen M. Young
Works (8)
Updated: July 5th, 2023 16:02
2013 journal article
Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis
Inflammatory Bowel Diseases, 19(13), 2867–2877.
co-author countries:
United States of America 🇺🇸
Contributors: P. Nighot n, n, M. Nighot n, M. Rawat*, E. Sung n, N. Maharshak *, S. Plevy*, T. Ma*, A. Blikslager n
author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
europepmc.org (repository)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2005 journal article
Faecal bile loss in horses following small intestinal resection
EQUINE VETERINARY JOURNAL, 37(1), 92–94.
co-author countries:
United States of America 🇺🇸
author keywords: horse; small intestine; resection; bile; faeces
MeSH headings : Analysis of Variance; Animals; Bile Acids and Salts / analysis; Colic / metabolism; Colic / surgery; Colic / veterinary; Feces / chemistry; Horse Diseases / metabolism; Horse Diseases / surgery; Horses; Intestine, Small / surgery
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.
Contributors: J. Tomlinson*, O. Wilder, * & A. Blikslager*
MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism
American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.
Contributors: D. Shifflett*, F. Bottone Jr., *, A. Moeser*, S. Jones* & A. Blikslager*
author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2003 journal article
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.
co-author countries:
United States of America 🇺🇸
author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2002 journal article
Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2
Gut, 50(5), 615–623.
co-author countries:
United States of America 🇺🇸
Contributors: A. Blikslager n , D. Zimmel*, *, N. Campbell, D. Little* & R. Argenzio*
MeSH headings : Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids / biosynthesis; Female; Ileum / blood supply; Ileum / drug effects; Indomethacin / pharmacology; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Ischemia / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / physiology; Male; Nitrobenzenes / pharmacology; Permeability; Prostaglandin-Endoperoxide Synthases / physiology; Sulfonamides / pharmacology; Swine
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2001 journal article
PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 281(2), G375–G381.
co-author countries:
United States of America 🇺🇸
author keywords: mucosa; barrier function; adenosine 3 ' 5 '-cyclic monophosphate; G protein; short-circuit current
MeSH headings : Animals; Calcimycin / pharmacology; Calcium Signaling; Culture Techniques; Cyclic AMP / biosynthesis; Dinoprostone / analogs & derivatives; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Ileal Diseases / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / physiopathology; Ionophores / pharmacology; Ischemia / physiopathology; Male; Receptor Cross-Talk; Receptors, Prostaglandin E / antagonists & inhibitors; Receptors, Prostaglandin E / metabolism; Swine
Sources: Web Of Science, Crossref
Added: August 6, 2018
2000 journal article
Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 278(2), G207–G216.
co-author countries:
France 🇫🇷 United States of America 🇺🇸
author keywords: mucosa; chloride secretion; transmucosal resistance; tyrosine kinase
MeSH headings : 8-Bromo Cyclic Adenosine Monophosphate / pharmacology; Animals; Chlorides / metabolism; Cyclic GMP / pharmacology; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Genistein / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Male; Mannitol / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Swine / physiology; Tetradecanoylphorbol Acetate / pharmacology; Tritium
Sources: Web Of Science, Crossref
Added: August 6, 2018
