Karen M. Young

Works (8)

Updated: July 5th, 2023 16:02

2013 journal article

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis

Inflammatory Bowel Diseases, 19(13), 2867–2877.

By: P. Nighot n, K. Young n, M. Nighot n, M. Rawat *, E. Sung  n, N. Maharshak *, S. Plevy*, T. Ma *, A. Blikslager n 

Contributors: P. Nighot n, K. Young n, M. Nighot n, M. Rawat *, E. Sung  n, N. Maharshak *, S. Plevy*, T. Ma *, A. Blikslager n 

author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
TL;DR: ClC-2 plays a critical role in experimental colitis in that its absence increases disease activity, reduces barrier function and recovery, and perturbs TJs. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Faecal bile loss in horses following small intestinal resection

EQUINE VETERINARY JOURNAL, 37(1), 92–94.

By: D. Little n, C. White n, K. Young n & A. Blikslager n 

author keywords: horse; small intestine; resection; bile; faeces
MeSH headings : Analysis of Variance; Animals; Bile Acids and Salts / analysis; Colic / metabolism; Colic / surgery; Colic / veterinary; Feces / chemistry; Horse Diseases / metabolism; Horse Diseases / surgery; Horses; Intestine, Small / surgery
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia

AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.

By: J. Tomlinson n, B. Wilder n, K. Young n & A. Blikslager n 

Contributors: J. Tomlinson n, O. Wilder n, K. Young n & A. Blikslager n 

MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
TL;DR: Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.

By: D. Shifflett n, F. Bottone, K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
TL;DR: PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.

By: D. Little*, R. Dean, K. Young*, S. McKane n, L. Martin n, S. Jones* , A. Blikslager* 

author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
TL;DR: These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2002 journal article

Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2

Gut, 50(5), 615–623.

By: A. Blikslager n , D. Zimmel, K. Young, N. Campbell, D. Little & R. Argenzio

Contributors: A. Blikslager n , D. Zimmel, K. Young, N. Campbell, D. Little & R. Argenzio

MeSH headings : Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids / biosynthesis; Female; Ileum / blood supply; Ileum / drug effects; Indomethacin / pharmacology; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Ischemia / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / physiology; Male; Nitrobenzenes / pharmacology; Permeability; Prostaglandin-Endoperoxide Synthases / physiology; Sulfonamides / pharmacology; Swine
TL;DR: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 orCOX-2. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2001 journal article

PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 281(2), G375–G381.

By: A. Blikslager n , S. Pell n & K. Young n

author keywords: mucosa; barrier function; adenosine 3 ' 5 '-cyclic monophosphate; G protein; short-circuit current
MeSH headings : Animals; Calcimycin / pharmacology; Calcium Signaling; Culture Techniques; Cyclic AMP / biosynthesis; Dinoprostone / analogs & derivatives; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Ileal Diseases / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / physiopathology; Ionophores / pharmacology; Ischemia / physiopathology; Male; Receptor Cross-Talk; Receptors, Prostaglandin E / antagonists & inhibitors; Receptors, Prostaglandin E / metabolism; Swine
TL;DR: Treatment of tissues with deoxy-PGE1 and the Ca(2+) ionophore A-23187 stimulated synergistic increases in R and cAMP, indicating that PGE2 triggers recovery of R via EP receptor cross talk mechanisms involving cAMP and intracellular Ca( 2+). (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2000 journal article

Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 278(2), G207–G216.

By: A. Blikslager* , M. Roberts*, K. Young*, J. Rhoads * & R. Argenzio n

author keywords: mucosa; chloride secretion; transmucosal resistance; tyrosine kinase
MeSH headings : 8-Bromo Cyclic Adenosine Monophosphate / pharmacology; Animals; Chlorides / metabolism; Cyclic GMP / pharmacology; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Genistein / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Male; Mannitol / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Swine / physiology; Tetradecanoylphorbol Acetate / pharmacology; Tritium
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Sources: Web Of Science, Crossref
Added: August 6, 2018

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