@article{morrow_meyer_roberts_lascelles_2006, title={Financial and welfare implications of immediately euthanizing compromised nursery pigs}, volume={14}, number={1}, journal={Journal of Swine Health and Production}, author={Morrow, W. E. M. and Meyer, R. E. and Roberts, J. and Lascelles, D.}, year={2006}, pages={25–34} }
 @article{poulson_vujaskovic_gaskin_larue_meyer_prescott_samulski_thrall_dewhirst_2004, title={Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia}, volume={20}, ISSN={["1464-5157"]}, DOI={10.1080/0265673032000173906}, abstractNote={The objectives of this study were to compare the effects of two vasodilators, sodium nitroprusside (SNP) and calcitonin gene-related peptide (CGRP) on mean arterial pressure (MAP), heart rate (HR) and temperatures in tumour and surrounding normal tissue during local hyperthermia treatment. Eleven tumour-bearing pet dogs with spontaneous soft tissue sarcomas were given SNP intravenously during local hyperthermia. The drug infusion rate was adjusted to maintain a 20% decrease in MAP. The median (95% CI) increase in the temperature distribution descriptors T90 and T50 was 0.2°C (0.0–0.4°C, p = 0.02) and 0.4°C (0.1–0.7°C, p = 0.02), respectively, in tumour. Normal subcutaneous tissue temperatures were mildly increased but remained below the threshold for thermal injury. The effects of CGRP were investigated in six tumour-bearing dogs following a protocol similar to that used for SNP. The median (interquartile (IQ) range) decrease in mean arterial pressure was 19% (15–26%) after CGRP administration and a significant increase was seen in tumour but not normal subcutaneous tissue temperatures. The median (95% CI) increase in the temperature distribution descriptors T90 and T50 was 0.5°C (0.1–1.6°C, p = 0.03) and 0.8°C (0.1–1.6°C, p = 0.13), respectively. Administration of SNP or CGRP did not result in local or systemic toxicity in tumour-bearing dogs. However, the magnitude of increase in tumour temperatures was not sufficient to improve the likelihood of increased response rates. Therefore, there is little justification for translation of this approach to human trials using conventional local hyperthermia.}, number={5}, journal={INTERNATIONAL JOURNAL OF HYPERTHERMIA}, author={Poulson, JM and Vujaskovic, Z and Gaskin, AA and Larue, SM and Meyer, RE and Prescott, DM and Samulski, TV and Thrall, DE and Dewhirst, MW}, year={2004}, month={Aug}, pages={477–489} }
 @article{meyer_braun_dewhirst_2001, title={Anesthetic considerations for the study of murine tumor models}, journal={Tumor models in cancer research}, publisher={Totowa, NJ: Humana Press}, author={Meyer, R. E. and Braun, R. D. and Dewhirst, M. W.}, year={2001}, pages={407–431} }
 @article{poulson_dewhirst_gaskin_vujaskovic_samulski_prescott_meyer_page_thrall_2000, title={Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs}, volume={14}, number={6}, journal={In Vivo (Athens, Greece)}, author={Poulson, J. M. and Dewhirst, M. W. and Gaskin, A. A. and Vujaskovic, Z. and Samulski, T. V. and Prescott, D. M. and Meyer, R. E. and Page, R. L. and Thrall, D. E.}, year={2000}, pages={709–714} }
 @article{meyer_braun_rosner_dewhirst_2000, title={Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion}, volume={154}, ISSN={["0033-7587"]}, DOI={10.1667/0033-7587(2000)154[0196:LCHIVC]2.0.CO;2}, abstractNote={Abstract Meyer, R. E., Braun, R. D., Rosner, G. L. and Dewhirst, M. W. Local 42°C Hyperthermia Improves Vascular Conductance of the R3230Ac Rat Mammary Adenocarcinoma during Sodium Nitroprusside Infusion. The effect of sodium nitroprusside-induced hypotension on the perfusion of the R3230 adenocarcinoma during local 42°C hyperthermia was studied using a combination of intravital microscopy and laser Doppler flowmetry. Fischer 344 rats were implanted with dorsal skin flap window chambers containing the R3230Ac tumor and allocated to three treatment groups (34°C with nitroprusside, 42°C with nitroprusside, and 42°C with 0.9% saline). After baseline observation at 34°C, tumors were locally heated to 42°C using a water bath and either 0.9% saline or nitroprusside sufficient to reduce blood pressure 20% below pretreatment baseline was infused. Nitroprusside at 34°C decreased tumor vascular conductance 40% with no effect on the diameter of arterioles entering the tumor. The diameter of arterioles entering 42°C heated tumors increased 35% independent of blood pressure change. Saline at 42°C had no effect on tumor vascular conductance; however, nitroprusside at 42°C increased tumor vascular conductance 55%. Local 42°C tumor heating, combined with a moderate reduction in blood pressure with nitroprusside, overrides the vascular steal effect associated with reduced perfusion pressure alone and results in improved tumor perfusion. Observations of the effect of vasodilator substances on normothermic tumor perfusion cannot be extrapolated to situations where moderate hyperthermia is used.}, number={2}, journal={RADIATION RESEARCH}, author={Meyer, RE and Braun, RD and Rosner, GL and Dewhirst, MW}, year={2000}, month={Aug}, pages={196–201} }
 @misc{dewhirst_meyer_bonaventura_deangelo_2000, title={Methods for improving therapeutic effectiveness of treatment of vascularization disorders}, volume={6020308}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Dewhirst, M. W. and Meyer, R. E. and Bonaventura, J. and DeAngelo, J.}, year={2000} }
 @article{vujaskovic_poulson_gaskin_thrall_page_charles_macfall_brizel_meyer_prescott_et al._2000, title={Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment}, volume={46}, ISSN={["0360-3016"]}, DOI={10.1016/s0360-3016(99)00362-4}, abstractNote={The objectives of this study were to evaluate effects of hyperthermia on tumor oxygenation, extracellular pH (pHe), and blood flow in 13 dogs with spontaneous soft tissue sarcomas prior to and after local hyperthermia.Tumor pO2 was measured using an Eppendorf polarographic device, pHe using interstitial electrodes, and blood flow using contrast-enhanced magnetic resonance imaging (MRI).There was an overall improvement in tumor oxygenation observed as an increase in median pO2 and decrease in hypoxic fraction (% of pO2 measurements <5 mm Hg) at 24-h post hyperthermia. These changes were most pronounced when the median temperature (T50) during hyperthermia treatment was less than 44 degrees C. Tumors with T50 > 44 degrees C were characterized by a decrease in median PO2 and an increase in hypoxic fraction. Similar thermal dose-related changes were observed in tumor perfusion. Perfusion was significantly higher after hyperthermia. Increases in perfusion were most evident in tumors with T50 < 44 degrees C. With T50 > 44 degrees C, there was no change in perfusion after hyperthermia. On average, pHe values declined in all animals after hyperthermia, with the greatest reduction seen for larger T50 values.This study suggests that hyperthermia has biphasic effects on tumor physiologic parameters. Lower temperatures tend to favor improved perfusion and oxygenation, whereas higher temperatures are more likely to cause vascular damage, thus leading to greater hypoxia. While it has long been recognized that such effects occur in rodent tumors, this is the first report to tie such changes to temperatures achieved during hyperthermia in the clinical setting. Furthermore, it suggests that the thermal threshold for vascular damage is higher in spontaneous tumors than in more rapidly growing rodent tumors.}, number={1}, journal={INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS}, author={Vujaskovic, Z and Poulson, JM and Gaskin, AA and Thrall, DE and Page, RL and Charles, HC and MacFall, JR and Brizel, DM and Meyer, RE and Prescott, DM and et al.}, year={2000}, month={Jan}, pages={179–185} }
 @article{meyer_1999, title={Anesthesia hazards to animal workers}, volume={14}, number={2}, journal={Occupational Medicine. State of the Art Reviews in Occupational Medicine}, author={Meyer, R. E.}, year={1999}, pages={225–234} }
 @article{stoskopf_meyer_jones_baumbarger_1999, title={Field immobilization and euthanasia of American opossum}, volume={35}, ISSN={["0090-3558"]}, DOI={10.7589/0090-3558-35.1.145}, abstractNote={Seventeen recently trapped opossum, Didelphis virginiana, (median weight 2.45 kg; range = 1.6–5.0 kg; quartiles = 1.8–3.3 kg) were immobilized with either telazol (15 or 30 mg/kg) or a mixture of medetomidine (100 μg/ kg), butorphanol (0.2 mg/kg), and ketamine HCl (10 mg/kg) based on estimated weights. Anesthetized animals were subjected to cardiac puncture for blood withdrawal and toe pinch. Euthanasia was accomplished by intracardiac administration of 1 ml of concentrated pentobarbital sodium/phenytoin solution. Weights were underestimated for 14 of 17 animals, but were within 0.5 kg of the actual weight. Both drug combinations provided rapid and calm immobilization. Median time to recumbency for the medetomidine–butorphanol–ketamine group (n = 5) was 6 min (range = 4–10 min; quartiles = 6 and 8 min). The median time to recumbency was not statistically different for the low (n = 6) and high dose (n = 6) telazol groups, 3 and 3.5 min respectively (quartiles 3; 3.5 and 4; 5.5 min). The stronger heart beat with telazol immobilization facilitated cardiac puncture. All five animals administered the medetomidine–butorphanol–ketamine mixture and three of six animals given the low telazol dose reacted to cardiac puncture. Only one of six animals given the estimated 30 mg/kg dose of telazol reacted slightly to cardiac puncture. We conclude that 30 mg/kg telazol provides sufficient immobilization and analgesia to allow accurate cardiac puncture of the opossum if the procedure is performed within 5 to 10 min of recumbency. Intracardiac administration of concentrated pentobarbital sodium/phenytoin solution followed by bilateral thoracotomy provides appropriate euthanasia suitable for field situations.}, number={1}, journal={JOURNAL OF WILDLIFE DISEASES}, author={Stoskopf, MK and Meyer, RE and Jones, M and Baumbarger, DO}, year={1999}, month={Jan}, pages={145–149} }
 @misc{dewhirst_meyer_bonaventura_deangelo_1998, title={Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders}, volume={5788958}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Dewhirst, M. W. and Meyer, R. E. and Bonaventura, J. and DeAngelo, J.}, year={1998} }
 @article{lee_meyer_sullivan_davidson_swanson_hellyer_1998, title={Respiratory depressant and skeletal muscle relaxant effects of low-dose pancuronium bromide in spontaneously breathing, isoflurane-anesthetized dogs}, volume={27}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1998.tb00159.x}, abstractNote={Objective—To assess and compare the respiratory depressant and skeletal muscle relaxant effects of two low doses of a nondepolarizing neuromuscular blocker, pancuronium bromide. To determine if a “low dose” of pancuronium bromide can produce selective skeletal muscle relaxation in extraocular muscles sufficient to perform intraocular surgery while sparing or minimizing depression of muscles of ventilation.}, number={5}, journal={VETERINARY SURGERY}, author={Lee, DD and Meyer, RE and Sullivan, TC and Davidson, MG and Swanson, CR and Hellyer, PW}, year={1998}, pages={473–479} }
 @misc{dewhirst_meyer_bonaventura_deangelo_1997, title={Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders}, volume={5612310}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Dewhirst, M. W. and Meyer, R. E. and Bonaventura, J. and DeAngelo, J.}, year={1997} }
 @article{meyer_1997, title={Myocardial necrosis and sudden death after an episode of aggressive behavior in a dog}, volume={211}, number={11}, journal={Journal of the American Veterinary Medical Association}, author={Meyer, R. E.}, year={1997}, pages={1373} }
 @article{hahn_braun_dewhirst_shan_snyder_taube_ong_rosner_dodge_bonaventura_et al._1997, title={Stroma-free human hemoglobin a decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure}, volume={147}, ISSN={["0033-7587"]}, DOI={10.2307/3579420}, abstractNote={We examined the effect of a nitric oxide (NO) quencher, stroma-free human hemoglobin A (HbA0; 0.01, 0.05, 0.1, 0.2 g/kg), on the blood flow measured using the Doppler flow technique, tumor oxygen pressure (pO2) and the diameter of the arterioles using R3230Ac mammary adenocarcinoma as the tumor model. In female Fischer 344 rats with 1-cm-diameter tumors implanted in the lateral aspect of the left quadriceps, intravenous infusion of 0.1 and 0.2 g/kg HbA0 decreased both central tumor and peripheral tumor blood flow by 20-30% (P < 0.05). Tumor pO2 decreased 28% with 0.2 g/kg HbA0, from 15 mm Hg (baseline) to 11 mm Hg at 10 min (P = 0.02). Although 0.2 g/kg HbA0 increased blood flow 55% in the left quadriceps muscle proximal to the implanted tumor (P < 0.05), HbA0 had little effect on blood flow in right quadriceps muscle with no tumor implanted, and increased right quadriceps pO2, from 21 mm Hg (baseline) to 23 mm Hg at 10 min (P = 0.03). HbA0 increased mean arterial pressure 5-10% in a manner that was dependent on dose while heart rate concurrently decreased 9-19%. The diameter of the arterioles supplying the tumor was rapidly reduced 10% by 0.2 g/kg HbA0 (P = 0.037) and remained stable through 60 min of observation (P = 0.005). HbA0 selectively reduces tumor blood flow and tumor pO2 through vasoconstriction of the arterioles supplying the tumor. Vascular NO quenching provides an alternative to NO synthase inhibition as a means to achieve the goal of selective tumor hypoxia.}, number={2}, journal={RADIATION RESEARCH}, author={Hahn, JS and Braun, RD and Dewhirst, MW and Shan, SQ and Snyder, SA and Taube, JM and Ong, ET and Rosner, GL and Dodge, RK and Bonaventura, J and et al.}, year={1997}, month={Feb}, pages={185–194} }
 @inbook{meyer_dewhirst_1997, title={The use of blood substitutes in tumor therapy}, booktitle={Red blood cell substitutes: Basic principles and clinical application}, publisher={New York: Marcel Dekker}, author={Meyer, R. E. and Dewhirst, M. W.}, editor={A. S. Rudolph, R. Rabinovici and Feuerstein, G. Z.Editors}, year={1997} }
 @misc{dewhirst_meyer_bonaventura_deangelo_1996, title={Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders}, volume={5554638}, publisher={Washington, DC: U.S. Patent and Trademark Office}, author={Dewhirst, M. W. and Meyer, R. E. and Bonaventura, J. and DeAngelo, J.}, year={1996} }
 @article{meyer_page_thrall_1991, title={Effect of a passive heat and moisture exchanger on esophageal temperature in tumor-bearing dogs during whole-body hyperthermia}, volume={52}, number={10}, journal={American Journal of Veterinary Research}, author={Meyer, R. E. and Page, R. L. and Thrall, D. E.}, year={1991}, pages={1688} }