Susan Marie Orton

Works (3)

Updated: July 20th, 2023 16:20

2007 journal article

A novel gene from Brugia sp that encodes a cytotoxic fatty acid binding protein allergen recognized by canine monoclonal IgE and serum IgE from infected dogs

JOURNAL OF PARASITOLOGY, 93(6), 1378–1387.

By: S. Orton n, P. Arasu n & B. Hammerberg n

MeSH headings : Allergens / chemistry; Allergens / genetics; Allergens / immunology; Amino Acid Sequence; Animals; Antibodies, Helminth / immunology; Antibodies, Monoclonal / immunology; Antigens, Helminth / chemistry; Antigens, Helminth / genetics; Antigens, Helminth / immunology; B-Lymphocytes / immunology; Base Sequence; Blotting, Western; Brugia / genetics; Brugia / immunology; Brugia pahangi / genetics; Brugia pahangi / immunology; Disease Models, Animal; Dogs; Epitopes / immunology; Fatty Acid-Binding Proteins / chemistry; Fatty Acid-Binding Proteins / genetics; Fatty Acid-Binding Proteins / immunology; Female; Filariasis / immunology; Filariasis / parasitology; Gerbillinae; Glutathione Transferase / genetics; Glutathione Transferase / immunology; Immunoglobulin E / blood; Immunoglobulin E / immunology; Male; Molecular Sequence Data; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / immunology; Sequence Homology
TL;DR: This 35-kDa protein seems to be highly conserved in different stages and species of filarids, and it represents a previously unknown allergen that is possibly involved in the pathogenesis of filarial disease. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

IgE is present on peripheral blood monocytes and B cells in normal dogs and dogs with atopic dermatitis but there is no correlation with serum IgE concentrations

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 85(3-4), 225–232.

By: H. Jackson n, S. Orton n & B. Hammerberg n

author keywords: IgE; canine PBMCs; canine atopic dermatitis
MeSH headings : Animals; Antigens, CD1 / blood; B-Lymphocytes / immunology; B-Lymphocytes / metabolism; Dermatitis, Atopic / blood; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / blood; Dog Diseases / immunology; Dogs / blood; Dogs / immunology; Female; Flow Cytometry / veterinary; Glycoproteins / blood; Immunoglobulin E / blood; Immunoglobulin E / immunology; Lipopolysaccharide Receptors / blood; Male; Monocytes / immunology; Monocytes / metabolism; Receptors, Complement 3d / blood
TL;DR: Canine AD is associated with more variability in circulating monocyte numbers and lower numbers of monocytes expressing IgE than control dogs, and there is no correlation between circulating and cell bound IgE in any of the leucocyte populations studied. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Skin mast cell histamine release following stem cell factor and high-affinity immunoglobulin E receptor cross-linking in dogs with atopic dermatitis

VETERINARY DERMATOLOGY, 12(6), 339–346.

By: B. Hammerberg*, T. Olivry n  & S. Orton*

Contributors: B. Hammerberg*, T. Olivry n  & S. Orton*

author keywords: atopic dermatitis; histamine; mast cell; stem cell factor
MeSH headings : Animals; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dogs / immunology; Enzyme-Linked Immunosorbent Assay / veterinary; Histamine Release / drug effects; Immunoglobulin E / immunology; Immunohistochemistry / veterinary; Injections, Intradermal / veterinary; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / metabolism; Receptors, IgE / drug effects; Skin / cytology; Stem Cell Factor / pharmacology
TL;DR: Dermal SCF secretion could potentiate histamine release following IgE receptor cross-linking and thus, could be one of the explanations for the inherent mast cell hyperexcitability observed in canine atopic dermatitis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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