@article{karnati_gao_gao_yang_ni_sankar_wang_2002, title={A glucose-selective fluorescence sensor based on boronic acid-diol recognition}, volume={12}, ISSN={["0960-894X"]}, DOI={10.1016/S0960-894X(02)00767-9}, abstractNote={A glucose selective diphenylboronic acid fluorescent sensor (10a) with a K(a) of 1472M(-1) has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio).}, number={23}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Karnati, VV and Gao, XM and Gao, SH and Yang, WQ and Ni, WJ and Sankar, S and Wang, BH}, year={2002}, month={Dec}, pages={3373–3377} } @article{yang_gao_gao_karnati_ni_wang_hooks_carson_weston_2002, title={Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X}, volume={12}, ISSN={["0960-894X"]}, DOI={10.1016/S0960-894X(02)00339-6}, abstractNote={A series of fluorescent diboronic acids was synthesized in nine steps as potential sensors for sialyl Lewis X (sLex). The fluorescent binding studies of these sensors with sLex were carried out in a mixed aqueous solution. Compound 7e was found to show the strongest fluorescence enhancement upon binding with sLex. Using cell cultures, 7e was shown to label sLex-expressing HEPG2 cells at 1 microM, while non-sLex-expressing cells were not labeled.}, number={16}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Yang, WQ and Gao, SH and Gao, XM and Karnati, VVR and Ni, WJ and Wang, BH and Hooks, WB and Carson, J and Weston, B}, year={2002}, month={Aug}, pages={2175–2177} } @article{gao_wang_wang_2001, title={A new OsO4-mediated carbon-carbon bond cleavage reaction leading to the formation of anthraquinone}, number={1}, journal={Chemistry Letters}, author={Gao, S. H. and Wang, W. and Wang, B. H.}, year={2001}, pages={48–49} } @article{gao_wang_wang_2001, title={Building fluorescent sensors for carbohydrates using template-directed polymerizations}, volume={29}, ISSN={["0045-2068"]}, DOI={10.1006/bioo.2001.1219}, abstractNote={The ability to custom-make fluorescent sensors for different analytes could have a tremendous impact in a variety of areas. Template-directed polymerization or molecular imprinting seems to be a promising approach for the preparation of high-affinity and specific binding sites for different template molecules. However, the application of molecular imprinting in the preparation of fluorescent sensors has been hampered by the lack of suitable fluorescent tags, which would respond to the binding event with significant fluorescence intensity changes. We have designed and synthesized a fluorescent monomer (1) that allows for the preparation of fluorescent sensors of cis diols using molecular imprinting methods. This monomer has been used for the preparation of imprinted polymers as sensitive fluorescent sensors for D-fructose. The imprinted polymers prepared showed significant fluorescence intensity enhancement upon binding with the template carbohydrate.}, number={5}, journal={BIOORGANIC CHEMISTRY}, author={Gao, SH and Wang, W and Wang, BH}, year={2001}, month={Oct}, pages={308–320} } @article{gao_herzig_wang_2001, title={OsO4-mediated conversion of primary amines to nitriles}, number={4}, journal={Synthesis (Stuttgart)}, author={Gao, S. H. and Herzig, D. and Wang, B. H.}, year={2001}, pages={544–546} } @article{springsteen_ballard_gao_wang_wang_2001, title={The development of photometric sensors for boronic acids}, volume={29}, ISSN={["0045-2068"]}, DOI={10.1006/bioo.2001.1217}, abstractNote={Boronic acids bind certain 1,2- and 1,3-diols with high affinity through reversible formation of boronate esters. They have been utilized as the recognition moiety for artificial receptors, particularly receptors for carbohydrates that have cis-diol moieties. Therefore, sensors for boronic acids could serve as universal reporters for monitoring boronate formation. This paper reports the design and synthesis of a series of photometric chemosensors for phenylboronic acid using diethanolamine as the recognition moiety. Diethanolamine, which binds strongly to boronic acids, has been linked to three different types of optical reporters. A photoinduced electron transfer system based on the anthracene fluorophore has been used to create sensors that show up to a fivefold increase in fluorescent intensity in the presence of millimolar concentrations of phenylboronic acid. Sensor designs based on the restriction of free rotation of extended pi systems and on the perturbed electronic properties of azo dyes are also included. This work demonstrates that sensors based on several different designs can be used for the detection of boronic acids.}, number={5}, journal={BIOORGANIC CHEMISTRY}, author={Springsteen, G and Ballard, CE and Gao, S and Wang, W and Wang, BH}, year={2001}, month={Oct}, pages={259–270} } @article{wang_springsteen_gao_wang_2000, title={The first fluorescent sensor for boronic and boric acids with sensitivity at sub-micromolar concentrations}, number={14}, journal={Chemical Communications (Cambridge, England)}, author={Wang, W. and Springsteen, G. and Gao, S. H. and Wang, B. H.}, year={2000}, pages={1283–1284} } @article{wang_gao_wang_1999, title={Building fluorescent sensors by template polymerization: The preparation of a fluorescent sensor for D-Fructose}, volume={1}, ISSN={["1523-7060"]}, DOI={10.1021/ol9908732}, abstractNote={[formula: see text] The application of molecular imprinting in making fluorescent sensors has been hampered by the lack of suitable fluorescent tags, which would respond to the binding event with significant fluorescence intensity changes. We have designed and synthesized a fluorescent monomer which allows for the preparation of fluorescent sensors of cis diols using molecular imprinting methods. This monomer was used for the preparation of sensitive fluorescent sensors for D-fructose.}, number={8}, journal={ORGANIC LETTERS}, author={Wang, W and Gao, SH and Wang, BH}, year={1999}, month={Oct}, pages={1209–1212} }