Works (12)

Updated: July 5th, 2023 16:03

2007 journal article

High-frequency reversion of geminivirus replication protein mutants during infection

JOURNAL OF VIROLOGY, 81(20), 11005–11015.

By: G. Arguello-Astorga n, J. Ascencio-Ibanez n, M. Dallas n, B. Orozco n & L. Hanley-Bowdoin n

MeSH headings : Arabidopsis / virology; Geminiviridae / genetics; Geminiviridae / physiology; Mosaic Viruses; Mutation, Missense; Plant Diseases / virology; Plant Viruses / genetics; Plant Viruses / physiology; Viral Proteins / genetics; Viral Proteins / metabolism; Viral Proteins / physiology; Virus Replication / genetics
TL;DR: There is strong selection for reversion of the TGMV L148V and CaLCuV L145A mutations but that the nature of the selected revertants is influenced by both the viral background and host components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

A novel motif in geminivirus replication proteins interacts with the plant retinoblastoma-related protein

JOURNAL OF VIROLOGY, 78(9), 4817–4826.

MeSH headings : Amino Acid Motifs; Amino Acid Sequence; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Geminiviridae / metabolism; Geminiviridae / pathogenicity; Solanum lycopersicum / virology; Molecular Sequence Data; Mutation; Plant Diseases / virology; Plant Leaves / virology; Plant Proteins / metabolism; Retinoblastoma Protein / metabolism; Tobacco / virology; Two-Hybrid System Techniques; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Replication
TL;DR: Results suggest that helix 4 and the conserved leucine residue are part of a pRBR-binding interface in begomovirus replication proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 patent

Geminivirus resistant transgenic plants

Washington, DC: U.S. Patent and Trademark Office.

By: L. Hanley-Bowdoin, B. Orozco, L. Kong & W. Gruissem

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants

EMBO JOURNAL, 19(13), 3485–3495.

By: L. Kong n, B. Orozco, J. Roe, S. Nagar, S. Ou, H. Feiler, T. Durfee, A. Miller ...

author keywords: AL1; cell cycle; differentiation; plant DNA virus; pRb
MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Base Sequence; DNA Primers; Geminiviridae / isolation & purification; Geminiviridae / metabolism; Geminiviridae / physiology; Plants / virology; Protein Binding; Retinoblastoma Protein / metabolism; Viral Proteins / metabolism; Virus Replication
TL;DR: The pRBR binding domain of AL1 is mapped between amino acids 101 and 180 and two mutants are identified that are differentially impacted for AL1–pRBR interactions during geminivirus infection of plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Geminiviruses - Models for plant DNA replication, transcription and cell cycle regulation ([correction to] vol 35, pg 105, 2000)

Critical Reviews in Biochemistry and Molecular Biology, 35(4), U4.

By: L. Hanley-Bowdoin, S. Settlage, B. Orozco, S. Nagar & D. Robertson

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Geminiviruses: Models for plant DNA replication, transcription, and cell cycle regulation

Critical Reviews in Biochemistry and Molecular Biology, 35(2), 105–140.

By: L. Hanley-Bowdoin, S. Settlage, B. Orozco, S. Nagar & D. Robertson

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The multifunctional character of a geminivirus replication protein is reflected by its complex oligomerization properties

JOURNAL OF BIOLOGICAL CHEMISTRY, 275(9), 6114–6122.

By: B. Orozco n, L. Kong n, L. Batts n, S. Elledge n & L. Hanley-Bowdoin n

MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; DNA / metabolism; DNA-Binding Proteins / chemistry; Geminiviridae / chemistry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Spodoptera / genetics; Transcription, Genetic; Transfection; Viral Proteins / chemistry; Viral Proteins / genetics; Virus Replication; Yeasts
TL;DR: Results suggested that different AL1 complexes mediate viral replication and transcriptional regulation and that replication interference involves multiple domains of the AL1 protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Geminiviruses: Models for plant DNA replication, transcription, and cell cycle regulation {review}

Critical Reviews in Plant Sciences, 18(1), 71–106.

By: L. Hanley-Bowdoin n, S. Settlage n, B. Orozco n, S. Nagar n & D. Robertson n

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Conserved sequence and structural motifs contribute to the DNA binding and cleavage activities of a geminivirus replication protein

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(38), 24448–24456.

By: B. Orozco n & L. Hanley-Bowdoin n

MeSH headings : Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Conserved Sequence; DNA, Single-Stranded / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Geminiviridae / physiology; Genetic Vectors; Glutathione Transferase; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Spodoptera; Transfection; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Replication
TL;DR: Results established that the conserved motifs in the AL1 N terminus contribute to DNA binding and cleavage with both activities displaying nearly identical amino acid requirements, however, DNA binding was readily distinguished from cleavage and ligation by its dependence on AL1/AL1 interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Multiple cis elements contribute to geminivirus origin function

VIROLOGY, 242(2), 346–356.

By: B. Orozco n, H. Gladfelter n, S. Settlage n, P. Eagle n, R. Gentry n & L. Hanley-Bowdoin n

MeSH headings : Base Sequence; DNA Replication / genetics; DNA Replication / physiology; DNA, Circular / genetics; DNA, Circular / physiology; DNA, Viral / genetics; DNA, Viral / physiology; Geminiviridae / genetics; Geminiviridae / physiology; Solanum lycopersicum / virology; Molecular Sequence Data; Nucleic Acid Conformation; Regulatory Sequences, Nucleic Acid; Replication Origin / genetics; Virus Replication / genetics; Virus Replication / physiology
TL;DR: The results demonstrated that the organization of TGMV plus-strand origin is complex, involving multiple cis elements that are likely to interact with each other during initiation of replication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

1997 journal article

Functional domains of a geminivirus replication protein

Journal of Biological Chemistry, 272(15), 9840–9846.

By: B. Orozco n, A. Miller n, S. Settlage n & L. Hanley-Bowdoin n

MeSH headings : Amino Acid Sequence; DNA / metabolism; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Peptide Mapping; Promoter Regions, Genetic; Protein Conformation; Viral Proteins / chemistry; Viral Proteins / genetics; Virus Replication
TL;DR: To identify the tomato golden mosaic virus AL1 domains that mediate protein oligomerization, DNA binding, and DNA cleavage, a series of truncated AL1 proteins were produced in a baculovirus expression system and assayed for each activity. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1996 journal article

A DNA structure is required for geminivirus replication origin function

Journal of Virology, 70(1), 148.

By: B. Orozco & L. Hanley-Bowdoin

Source: NC State University Libraries
Added: August 6, 2018

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