@article{parks_eisen_murray_2000, title={Correlated responses to selection for large body size in oMt1a-oGH mice: growth, feed efficiency and body composition}, volume={117}, ISSN={["1439-0388"]}, DOI={10.1046/j.1439-0388.2000.00253.x}, abstractNote={Summary}, number={6}, journal={JOURNAL OF ANIMAL BREEDING AND GENETICS}, author={Parks, KR and Eisen, EJ and Murray, JD}, year={2000}, month={Dec}, pages={385–405} }
 @article{parks_eisen_murray_2000, title={Correlated responses to selection for large body size in oMt1a-oGH transgenic mice: organ traits}, volume={23}, ISSN={["1415-4757"]}, DOI={10.1590/S1415-47572000000400011}, abstractNote={The objective of the present study was to compare correlated responses in liver, spleen, kidney, heart and testis absolute weights and as a percentage of 8-week body weight following selection for large 8-week body weight in twice-replicated nontransgenic and transgene-carrier lines of mice from two genetic backgrounds. The transgene was an ovine metallothionein 1a-ovine growth hormone (oMt1a-oGH) construct, which was activated by adding 25 mM ZnSO4 to the drinking water. Lines NM and NC were nontransgenic lines derived from a high-growth and randomly selected background, respectively. Lines TM and TC were transgene-carrier lines formed from the respective genetic backgrounds. Line CC was a nontransgenic control from the randomly selected background. At weaning, male mice from each line were assigned to either zinc supplemented or control drinking water. Toe-clips were assayed by PCR for the presence or absence of the transgene. Correlated responses of absolute weights of all organs in nontransgenic lines indicated moderately high genetic correlations of organ weights with body weight, but on a percentage of body weight basis, the correlated responses were much lower. The correlated responses in visceral organ weights were lower in the presence of the inactivated oMt1a-oGH transgene than in its absence. The presence of the activated oMt1a-oGH combined with the effects of selection for growth increase had a greater impact on increasing the size of the splanchnic organs than did selection for large body weight in the absence of the transgene.}, number={4}, journal={GENETICS AND MOLECULAR BIOLOGY}, author={Parks, KR and Eisen, EJ and Murray, JD}, year={2000}, month={Dec}, pages={771–780} }
 @article{parks_eisen_parker_hester_murray_2000, title={Correlated responses to selection for large body size in oMt1a-oGH transgenic mice: reproductive traits}, volume={75}, ISSN={["0016-6723"]}, DOI={10.1017/S001667239900436X}, abstractNote={Correlated responses in female reproductive performance were evaluated following short-term 
selection within full-sib families for increased 8-week body weight in two replicates of four lines of 
mice: two ovine metallothionein–ovine growth hormone (oMt1a-oGH) transgene-carrier lines, one 
from a high-growth background (TM) and one from a control background (TC), and two non-transgenic lines, one from each of these genetic backgrounds (NM and NC, respectively). A fifth 
line (CC), not containing the transgene, served as a randomly selected control. The initial 
frequency of the oMt1a-oGH transgene construct in the TM and TC lines was 0·5. The frequency 
of transgenic females sampled at generations 7 and 8 of selection was 84·0% and 6·1% in the TC 
and TM lines, respectively. No significant female infertility differences were detected between 
transgene-carrier and non-transgenic lines or between transgenic and non-transgenic mice within 
carrier lines, whereas high-growth background lines had a higher infertility than control 
background lines (P < 0·05). Correlated responses in the TC transgene-carrier line were suggestive 
of reduced reproductive performance as indicated by increased post-implantation mortality 
(P < 0·05), number of dead fetuses plus implants (P < 0·05), and loss of fetuses from day 16 to 
parturition (P < 0·001). For the first two traits, the negative correlated responses were accounted 
for by the reduced performance of transgenic compared with non-transgenic females. Embryos 
carrying the transgene may also have a lower viability. In contrast, the NC non-transgenic line did 
not exhibit reduced reproductive performance for these traits. The low frequency of the transgene 
in the high-growth background TM line was associated with reduced fitness and a lower additive 
effect for 8-week body weight compared with the control background TC line.}, number={2}, journal={GENETICAL RESEARCH}, author={Parks, KR and Eisen, EJ and Parker, IJ and Hester, LG and Murray, JD}, year={2000}, month={Apr}, pages={199–208} }