Sinjae Hyun

Works (10)

Updated: July 5th, 2023 16:01

2012 journal article

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

JOURNAL OF AEROSOL SCIENCE, 46, 34–52.

By: Z. Zhang n, C. Kleinstreuer n & S. Hyun*

author keywords: Respiratory deposition; Cigarette smoke particles; Subject-specific human upper airways; Computational analysis; Potential reduced exposure tobacco products
TL;DR: It is demonstrated that changes in cigarette composition significantly influence the hygroscopic growth of CSPs and is helpful for quantitatively evaluating the dose-exposure and subsequent health effects of both conventional and potentially less-harmful cigarettes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Particle-hemodynamics simulations and design options for surgical reconstruction of diseased carotid artery bifurcations

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 126(2), 188–195.

By: S. Hyun*, C. Kleinstreuer n, P. Longest n & C. Chen n

MeSH headings : Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases / physiopathology; Carotid Artery Diseases / surgery; Computer Simulation; Endarterectomy, Carotid; Hemorheology / methods; Humans; Models, Cardiovascular; Particle Size; Risk Assessment; Surgery, Computer-Assisted / methods
TL;DR: The methodology of "virtual prototyping" of branching blood vessels was applied to diseased external carotid artery segments to understand the underlying particle-hemodynamics and to provide various geometric design options for improved surgical reconstruction based on the minimization of critical hemodynamic wall parameters. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta

JOURNAL OF BIOMECHANICS, 36(8), 1185–1196.

By: . Buchanan  n, C. Kleinstreuer n, S. Hyun* & G. Truskey *

author keywords: computational blood flow simulation; rabbit aorta; atherosclerotic model; hemodynamic wall parameters; monocyte deposition; experimental data comparisons
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Blood Flow Velocity; Blood Pressure; Cell Adhesion / physiology; Cell Aggregation / physiology; Cell Movement / physiology; Computer Simulation; Coronary Artery Disease / pathology; Coronary Artery Disease / physiopathology; Elasticity; Endothelium, Vascular / physiology; Hemorheology / methods; Models, Cardiovascular; Monocytes / physiology; Physical Conditioning, Animal / physiology; Pulsatile Flow / physiology; Rabbits; Shear Strength
TL;DR: The results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions. (via Semantic Scholar)
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Added: August 6, 2018

2002 journal article

Acoustic streaming induced by ultrasonic flexural vibrations and associated enhancement of convective heat transfer

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 111(2), 875–883.

By: B. Loh n, S. Hyun n, P. Ro n & C. Kleinstreuer n

MeSH headings : Acoustics; Hot Temperature; Models, Theoretical; Ultrasonics; Vibration
TL;DR: Acoustic streaming induced by ultrasonic flexural vibrations and the associated convection enhancement are investigated and it is observed that the streaming velocity decreases with the excitation frequency, and with an open-ended channel, a substantial increase in streaming velocity is observed from CFD simulations. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy

COMPUTERS IN BIOLOGY AND MEDICINE, 31(5), 365–384.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

author keywords: endarterectomized carotid artery; particle-hemodynamics simulations; indicator functions; surgical reconstruction geometries
MeSH headings : Carotid Stenosis / pathology; Carotid Stenosis / physiopathology; Carotid Stenosis / surgery; Computer Simulation; Endarterectomy, Carotid / adverse effects; Endarterectomy, Carotid / methods; Endarterectomy, Carotid / statistics & numerical data; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / prevention & control; Stroke / prevention & control
TL;DR: The new carotid artery bifurcation design is based on the overall reduction of "disturbed flow" indicator functions, including the time-averaged wall shear stress angle deviation and a wall deposition parameter for critical blood particles, such as monocytes. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Hemodynamic parameters and early intimal thickening in branching blood vessels

Critical Reviews in Biomedical Engineering, 29(1), 1–64.

By: C. Kleinstreuer n, S. Hyun n, J. Buchanan  n, P. Longest n, J. Archie* & G. Truskey *

MeSH headings : Animals; Arteriosclerosis / physiopathology; Biological Transport; Carotid Arteries / physiology; Carotid Arteries / physiopathology; Compliance; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Hemodynamics; Humans; Hyperplasia; Hypertension / physiopathology; Models, Cardiovascular; Muscle, Smooth, Vascular / pathology; Muscle, Smooth, Vascular / physiopathology; Pulsatile Flow / physiology; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR: The focus is on the identification of susceptible sites in branching blood vessels and their subsequent redesign, employing hemodynamic wall parameters that indicate susceptible sites of intimal thickening and/or favorable conditions for thrombi formation. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Numerical simulation of mixed convection heat and mass transfer in a human inhalation test chamber

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 44(12), 2247–2260.

By: S. Hyun n & C. Kleinstreuer n

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11. Sustainable Cities and Communities (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Aerosol transport and deposition in sequentially bifurcating airways

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 122(2), 152–158.

By: J. Comer n, C. Kleinstreuer n, S. Hyun n & C. Kim*

MeSH headings : Aerosols; Biomedical Engineering; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Respiratory Physiological Phenomena; Respiratory System / anatomy & histology
TL;DR: The use of single bifurcation models was determined to be inadequate to resolve the complex fluid-particle interactions that occur in multigenerational airways. (via Semantic Scholar)
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2000 article

Computer simulation and geometric design of endarterectomized carotid artery bifurcations

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 53–59.

By: S. Hyun n, C. Kleinstreuer n & J. Archie*

author keywords: branching blood vessels; arterial diseases; particle-hemodynamics; numerical analysis
MeSH headings : Blood Flow Velocity; Carotid Arteries / anatomy & histology; Carotid Arteries / surgery; Computer Simulation; Endarterectomy, Carotid; Humans; Models, Cardiovascular
TL;DR: This computational study established surgical guidelines for optimal geometries of carotid endarterectomy reconstructions that may measurably reduce postoperative complications, that is, thrombosis, stroke, and/or restenosis, based on the underlying hypotheses that nonuniform hemodynamics, or "disturbed flows," are linked to arterial diseases. (via Semantic Scholar)
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2000 journal article

Hemodynamics analyses of arterial expansions with implications to thrombosis and restenosis

MEDICAL ENGINEERING & PHYSICS, 22(1), 13–27.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

author keywords: computational hemodynamics simulations; transient particle-hemodynamics; sudden and smooth expansions; arterial disease indicators; thrombosis; restenosis
MeSH headings : Arteries / pathology; Arteries / physiopathology; Carotid Artery, Common / pathology; Carotid Artery, Common / physiopathology; Endarterectomy, Carotid / adverse effects; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / physiopathology; Stress, Mechanical; Thrombosis / etiology; Thrombosis / pathology; Thrombosis / physiopathology
TL;DR: The regions near the expansion wall and the reattachment point are susceptible to both atherosclerotic lesion and thrombi formations as indicated by non-uniform hemodynamic indicators as well as blood particle accumulation and deposition. (via Semantic Scholar)
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