Patricia A. Spears

Works (21)

Updated: August 6th, 2023 21:16

2017 journal article

Postmastectomy radiotherapy: an american society of clinical oncology, american society for radiation oncology, and society of surgical oncology focused guideline update

Annals of Surgical Oncology, 24(1), 38–51.

By: A. Recht, E. Comen, R. Fine, G. Fleming, P. Hardenbergh, A. Ho, C. Hudis, E. Hwang ...

Source: NC State University Libraries
Added: August 6, 2018

2017 review

Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design

[Review of ]. npj Breast Cancer, 3.

By: J. Ligibel, W. Barry, C. Alfano, D. Hershman, M. Irwin, M. Neuhouser, C. Thomson, L. Delahanty ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Regarding current recommendations for postmastectomy radiation therapy in patients with one to three positive axillary lymph nodes reply

Journal of Clinical Oncology, 35(11), 1258–1258.

By: A. Recht, E. Comen, R. Fine, G. Fleming, P. Hardenbergh, A. Ho, C. Hudis, E. Hwang ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Listeria monocytogenes wall teichoic acid decoration in virulence and cell-to-cell spread

MOLECULAR MICROBIOLOGY, 101(5), 714–730.

By: P. Spears n, E. Havell n, T. Hamrick *, J. Goforth*, A. Levine*, S. Abraham*, C. Heiss *, P. Azadi *, P. Orndorff n

MeSH headings : Animals; Bacteriophages / metabolism; Cell Membrane / metabolism; Cell Wall / metabolism; Female; Listeria monocytogenes / metabolism; Listeria monocytogenes / pathogenicity; Listeriosis / microbiology; Liver / microbiology; Mice; Mutation; Peptidoglycan / metabolism; Spleen / microbiology; Teichoic Acids / metabolism; Virulence
TL;DR: Identification and interruption of WTA decoration pathways may provide a general strategy to discover non‐antibiotic therapeutics for gram positive infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Postmastectomy radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology focused guideline update

Practical Radiation Oncology, 6(6), E219–234.

By: A. Recht, E. Comen, R. Fine, G. Fleming, P. Hardenbergh, A. Ho, C. Hudis, E. Hwang ...

Source: NC State University Libraries
Added: August 6, 2018

2015 personal communication

National guidelines and level of evidence: Comments on some of the new recommendations in the American Society of Clinical Oncology and the College of American Pathologists human epidermal growth factor receptor 2 guidelines for breast cancer reply

By: A. Wolff, M. Hammond, D. Hicks, K. Allison, J. Bartlett, M. Bilous, P. Fitzgibbons, W. Hanna ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update

Archives of Pathology & Laboratory Medicine, 138(2), 241–256.

By: A. Wolff, M. Hammond, D. Hicks, M. Dowsett, L. McShane, K. Allison, D. Allred, J. Bartlett ...

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Extrauterine Listeriosis in the gravid mouse influences embryonic growth and development

PLoS One, 8(8).

By: M. Suyemoto, T. Hamrick, P. Spears, J. Horton, I. Washington, E. Havell, L. Borst , P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update

Journal of Clinical Oncology, 31(31), 3997-.

By: A. Wolff, M. Hammond, D. Hicks, M. Dowsett, L. McShane, K. Allison, D. Allred, J. Bartlett ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

In Vitro Properties of a Listeria monocytogenes Bacteriophage-Resistant Mutant Predict Its Efficacy as a Live Oral Vaccine Strain

INFECTION AND IMMUNITY, 79(12), 5001–5009.

By: P. Spears n, M. Suyemoto n, T. Hamrick*, R. Wolf n, E. Havell n & P. Orndorff n

MeSH headings : Administration, Oral; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / immunology; Bacterial Vaccines / standards; Bacteriophages / physiology; Cells, Cultured; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / virology; Listeriosis / microbiology; Listeriosis / prevention & control; Mice; Mice, Inbred BALB C; Mutagenesis, Insertional; Mutation; Time Factors; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / standards
TL;DR: The results indicate that oral administration of a profoundly attenuated listeria monocytogenes glcV mutant can safely elicit solid protective immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(14), 4655–4663.

By: S. Lee, A. Wyse, A. Lesher, M. Everett, L. Lou, Z. Holzknecht, J. Whitesides*, P. Spears n ...

MeSH headings : Animals; Escherichia coli K12 / genetics; Escherichia coli K12 / growth & development; Gastrointestinal Tract / microbiology; Longitudinal Studies; Mice; Restriction Mapping
TL;DR: The results suggest that monoassociated mice might be used as a tool for characterizing niches occupied by the intestinal flora and potentially as a method of targeting the evolution of bacteria for applications in biotechnology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Factors Associated with the Acquisition and Severity of Gestational Listeriosis

PLOS ONE, 5(9).

By: M. Suyemoto n, P. Spears n, T. Hamrick *, J. Barnes n, E. Havell & P. Orndorff n

MeSH headings : Animals; Disease Models, Animal; Female; Humans; Listeria / physiology; Listeriosis / embryology; Listeriosis / microbiology; Listeriosis / pathology; Liver / microbiology; Liver / pathology; Mice; Pregnancy; Pregnancy Complications, Infectious / microbiology; Pregnancy Complications, Infectious / pathology; Severity of Illness Index; Spleen / microbiology; Spleen / pathology
TL;DR: It was determined in mice that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development, and the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Identification and Characterization of Two Bordetella avium Gene Products Required for Hemagglutination

INFECTION AND IMMUNITY, 78(6), 2370–2376.

By: L. Temple *, D. Miyamoto*, M. Mehta *, C. Capitini *, S. Von Stetina*, H. Barnes n, V. Christensen n, J. Horton n, P. Spears n, P. Orndorff n

MeSH headings : Animals; Antibodies, Bacterial / immunology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bordetella avium / pathogenicity; Cell Adhesion; Cells, Cultured; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Epithelial Cells / microbiology; Erythrocytes / microbiology; Gene Order; Guinea Pigs; Hemagglutination; Hemagglutinins / genetics; Hemagglutinins / metabolism; Molecular Sequence Data; Mutagenesis, Insertional; Poultry Diseases / microbiology; Sequence Analysis, DNA; Sequence Deletion; Trachea / microbiology; Turkeys
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth

INFECTION AND IMMUNITY, 76(9), 4046–4054.

By: P. Spears n, M. Suyemoto n, A. Palermo n, J. Horton n, T. Hamrick*, E. Havell n, P. Orndorff n

MeSH headings : Animals; Bacterial Adhesion; Bacteriophages / physiology; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Genetic Complementation Test; Glycosyltransferases / genetics; Listeria monocytogenes / pathogenicity; Listeria monocytogenes / virology; Listeriosis / microbiology; Liver / microbiology; Mice; Mice, Inbred A; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Virus / genetics; Sequence Analysis, DNA; Spleen / microbiology; Survival Analysis; Viral Plaque Assay; Virulence; Virulence Factors / genetics; Virus Attachment
TL;DR: Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mouse enterocyte monolayers, rather, the mutation appeared to alter a subsequent step in intracellular replication measured by a reduction in plaque-forming efficiency and plaque size. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically

INFECTION AND IMMUNITY, 71(9), 5202–5209.

By: T. Hamrick  n, . Horton  n, P. Spears n, E. Havell n, I. Smoak n & P. Orndorff n

MeSH headings : Animals; Base Sequence; Colon / microbiology; Colony Count, Microbial; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Listeriosis / complications; Listeriosis / etiology; Liver / microbiology; Mice; Mutagenesis, Insertional; Pregnancy; Pregnancy Complications, Infectious / etiology; Risk Factors; Spleen / microbiology; Virulence / genetics
TL;DR: The ability of the 4nonb strain to produce a lethal infection in pregnant animals did not correlate with an increased incidence or level of liver and spleen colonization over that in nonpregnant females, but the lethality rate did correlate well with the rate at which embryos and their surrounding decidual covering became infected, suggesting that intrauterine infection could be responsible for the increased disease severity in the gravid females. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

The product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis

JOURNAL OF BACTERIOLOGY, 185(16), 5007–5011.

By: M. Valenski n, S. Harris n, P. Spears n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / genetics; Adhesins, Escherichia coli / metabolism; Alleles; Escherichia coli / genetics; Escherichia coli / metabolism; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Fimbriae, Bacterial / metabolism; Frameshift Mutation; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed
TL;DR: FimI has a required role in normal pilus biosynthesis and site-directed mutagenesis indicated that it produced polarity-like effects not seen with an in-frame fimI deletion mutation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Unexpected similarities between Bordetella avium and other pathogenic bordetellae

INFECTION AND IMMUNITY, 71(5), 2591–2597.

By: P. Spears n, L. Temple *, D. Miyamoto*, D. Maskell * & P. Orndorff n

MeSH headings : Amino Acid Sequence; Animals; Bacterial Proteins; Bird Diseases / microbiology; Bordetella / genetics; Bordetella / pathogenicity; Bordetella Infections / microbiology; Bordetella Infections / veterinary; Bordetella bronchiseptica / genetics; Bordetella bronchiseptica / pathogenicity; Bordetella pertussis / genetics; Bordetella pertussis / pathogenicity; Fimbriae Proteins / genetics; Fimbriae Proteins / physiology; Genes, Bacterial / physiology; Genotype; Molecular Sequence Data; Mutation; Phenotype; Turkeys / microbiology
TL;DR: The findings strengthen the connection between the causative agents and the pathogenesis of bordetellosis in all hosts and may help explain the striking similarities of the histopathologic characteristics of this upper airway disease in avian and mammalian species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 article

Breast cancer prevention through the eyes of a survivor

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol. 39, pp. 108–111.

By: P. Spears n

MeSH headings : Breast Neoplasms / prevention & control; Breast Neoplasms / therapy; Diet; Environment; Exercise; Female; Genetic Predisposition to Disease; Humans; Risk Factors; Survivors
TL;DR: In clinical trials there are many new targeted therapies being tested such as anti-angiogenesis antibodies and vaccines and vaccines which will be available in the future, however, in the area of prevention, the results of many studies are somewhat confusing and hard to understand. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities

JOURNAL OF BACTERIOLOGY, 183(13), 4099–4102.

By: S. Harris n, P. Spears n, E. Havell n, T. Hamrick n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Adhesins, Escherichia coli; Alleles; Chromosomes, Bacterial; Escherichia coli / physiology; Fimbriae Proteins; Fimbriae, Bacterial / genetics; Fimbriae, Bacterial / metabolism; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Recombination, Genetic
TL;DR: PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili that were noteworthy in part because both were altered in the normal range of cell types bound by FimH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A role for lipopolysaccharide in turkey tracheal colonization by Bordetella avium as demonstrated in vivo and in vitro

MOLECULAR MICROBIOLOGY, 36(6), 1425–1435.

By: P. Spears n, L. Temple * & P. Orndorff n

MeSH headings : Animals; Bordetella / genetics; Bordetella / growth & development; Bordetella / isolation & purification; Bordetella / pathogenicity; Bordetella Infections / microbiology; Bordetella Infections / veterinary; Genes, Bacterial; Genetic Complementation Test; Lipopolysaccharides / metabolism; Phenotype; Plasmids; Trachea / microbiology; Turkeys
TL;DR: This is the first characterization of LPS mutants of B. avium at the genetic level and the first report of virulence changes by both in vivo and in vitro measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Genetic characterization of Escherichia coli type 1 pilus adhesin mutants and identification of a novel binding phenotype

JOURNAL OF BACTERIOLOGY, 182(14), 4012–4021.

By: T. Hamrick n, S. Harris n, P. Spears n, E. Havell n, . Horton  n, P. Russell n, P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Escherichia coli; Animals; Bacterial Adhesion / genetics; Base Sequence; Chromosome Mapping; Erythrocytes / microbiology; Escherichia coli / genetics; Escherichia coli / pathogenicity; Fimbriae Proteins; Guinea Pigs; Hemagglutination Tests; Macrophages / microbiology; Mice; Molecular Sequence Data; Phenotype; Point Mutation
TL;DR: Temperature shift experiments revealed that new FimH biosynthesis was required for the phenotypic change, and a temperature-sensitive (ts) fimH mutant that agglutinated guinea pig erythrocytes but not at 42 degrees C was chosen for further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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