Phillip W. Longest

Works (13)

Updated: July 5th, 2023 16:01

2005 article

Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses

Longest, P. W., Kleinstreuer, C., & Deanda, A. (2005, December). ANNALS OF BIOMEDICAL ENGINEERING, Vol. 33, pp. 1752–1766.

By: P. Longest*, C. Kleinstreuer n & A. Deanda*

author keywords: particle hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia; pre-cuffed grafts; streamlined grafts
MeSH headings : Anastomosis, Surgical / adverse effects; Blood Vessel Prosthesis / adverse effects; Blood Vessel Prosthesis Implantation / adverse effects; Blood Vessels / physiopathology; Hemodynamics; Humans; Hyperplasia; Imaging, Three-Dimensional; Models, Cardiovascular; Nanostructures; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology
TL;DR: It was found that a pre-cuffed anastomosis does not offer a hemodynamic advantage over the conventional design considered with respect to the magnitude of the WSS field and the potential for platelet interactions with the vessel surface, highlighting the difficulty associated with designing an end-to-side distal anASTomosis with two-way outflow that is capable of simultaneously reducing multiple hemodynamic parameters. (via Semantic Scholar)
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Added: August 6, 2018

2004 journal article

Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 47(22), 4745–4759.

By: P. Longest* & C. Kleinstreuer n

author keywords: droplet heat and mass transfer; respiratory aerosols; near-wall droplet evaporation; droplet Nusselt and Sherwood number correlations
TL;DR: Multivariable Sherwood and Nusselt number correlations can be applied to effectively compute condensation and evaporation rates of potentially toxic or therapeutic aerosols in the upper respiratory tract, where non-uniform flow and wall proximity are expected to significantly affect droplet transport, deposition, and vapor formation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Particle-hemodynamics simulations and design options for surgical reconstruction of diseased carotid artery bifurcations

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 126(2), 188–195.

By: S. Hyun*, C. Kleinstreuer n, P. Longest n & C. Chen n

MeSH headings : Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases / physiopathology; Carotid Artery Diseases / surgery; Computer Simulation; Endarterectomy, Carotid; Hemorheology / methods; Humans; Models, Cardiovascular; Particle Size; Risk Assessment; Surgery, Computer-Assisted / methods
TL;DR: The methodology of "virtual prototyping" of branching blood vessels was applied to diseased external carotid artery segments to understand the underlying particle-hemodynamics and to provide various geometric design options for improved surgical reconstruction based on the minimization of critical hemodynamic wall parameters. (via Semantic Scholar)
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Added: August 6, 2018

2003 journal article

Comparison of blood particle deposition models for non-parallel flow domains

JOURNAL OF BIOMECHANICS, 36(3), 421–430.

By: P. Longest n & C. Kleinstreuer n

author keywords: particle-hemodynamics; monocytes; platelets; deposition; adhesion; computational fluid-particle dynamics; near-wall residence time
MeSH headings : Animals; Blood Flow Velocity; Blood Platelets / physiology; Blood Vessels / physiology; Cell Adhesion / physiology; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Monocytes / physiology; Particle Size; Platelet Adhesiveness / physiology; Rheology / methods; Sensitivity and Specificity; Shear Strength; Stress, Mechanical
TL;DR: Factors including the convective-diffusive transport of particles, finite particle size and inertia, as well as near-wall hydrodynamic interactions were found to significantly influence blood particle deposition. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Efficient computation of micro-particle dynamics including wall effects

COMPUTERS & FLUIDS, 33(4), 577–601.

By: P. Longest n, C. Kleinstreuer n & . Buchanan  n

TL;DR: The near-wall residence time (NWRT) model indicating the probability of blood particle deposition is presented and the proposed particle tracking algorithm stores all transient velocity field solution data on a shared memory architecture and computes particle trajectories using an adaptive parallel approach. (via Semantic Scholar)
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2003 journal article

Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(5), 671–681.

By: P. Longest n & C. Kleinstreuer n

MeSH headings : Anastomosis, Surgical; Animals; Arteries / physiopathology; Arteries / surgery; Blood Flow Velocity; Blood Pressure; Cell Movement; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Platelet Activation; Platelet Adhesiveness; Shear Strength; Surface Properties
TL;DR: The potential significance of platelet-wall interactions coinciding with regions of low WSS in the development of IH is indicated, as large variations in WSS-vector magnitude and direction were consistently observed along the IH-prone suture-line region. (via Semantic Scholar)
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2003 journal article

Particle hemodynamics analysis of Miller cuff arterial anastomosis

JOURNAL OF VASCULAR SURGERY, 38(6), 1353–1362.

By: P. Longest n, C. Kleinstreuer n & J. Archie n

MeSH headings : Anastomosis, Surgical / adverse effects; Anastomosis, Surgical / instrumentation; Blood Flow Velocity / physiology; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Femoral Artery / physiopathology; Femoral Artery / surgery; Humans; Hyperplasia / etiology; Hyperplasia / physiopathology; Models, Cardiovascular; Popliteal Artery / physiopathology; Popliteal Artery / surgery; Shear Strength; Vascular Patency / physiology; Vascular Resistance / physiology
TL;DR: The results imply that particle hemodynamics conditions engendered by Miller cuff geometry provide a mechanism that may account for redistribution of intimal hyperplasia. (via Semantic Scholar)
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2003 journal article

Particle-hemodynamics modeling of the distal end-to-side femoral bypass: effects of graft caliber and graft-end cut

MEDICAL ENGINEERING & PHYSICS, 25(10), 843–858.

By: P. Longest n & C. Kleinstreuer n

author keywords: particle-hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia
MeSH headings : Anastomosis, Surgical; Arteries / pathology; Blood Flow Velocity; Blood Platelets / metabolism; Blood Vessel Prosthesis; Femoral Artery / pathology; Femoral Vein / pathology; Humans; Hyperplasia; Models, Anatomic; Models, Cardiovascular; Models, Theoretical; Platelet Activation; Stress, Mechanical; Thrombosis
TL;DR: The results illustrate the need for alternative anastomotic designs with the intent of reducing critical hemodynamic wall parameters and mitigating regions of significant particle-wall interactions at locations critical to flow delivery. (via Semantic Scholar)
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2003 journal article

Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction

ANNALS OF BIOMEDICAL ENGINEERING, 31(1), 53–64.

By: P. Longest n, C. Kleinstreuer n, G. Truskey * & . Buchanan *

author keywords: atherosclerosis; particle hemodynamics; hemodynamic wall parameters; monocytes; adhesion; deposition; computational fluid dynamics; near-wall residence time
MeSH headings : Animals; Aorta, Abdominal / physiopathology; Arteriosclerosis / physiopathology; Blood Flow Velocity; Blood Physiological Phenomena; Blood Pressure; Celiac Artery / physiopathology; Cell Adhesion; Computer Simulation; Hemorheology / methods; Models, Cardiovascular; Monocytes; Particle Size; Rabbits; Shear Strength; Stress, Mechanical
TL;DR: Results indicate that cell transport and conditions for hemodyamically induced surface reactivity are necessary components in formulating an effective model for monocyte adhesion in complex three-dimensional vessel configurations. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Hemodynamic parameters and early intimal thickening in branching blood vessels

Critical Reviews in Biomedical Engineering, 29(1), 1–64.

By: C. Kleinstreuer n, S. Hyun n, J. Buchanan  n, P. Longest n, J. Archie* & G. Truskey *

MeSH headings : Animals; Arteriosclerosis / physiopathology; Biological Transport; Carotid Arteries / physiology; Carotid Arteries / physiopathology; Compliance; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Hemodynamics; Humans; Hyperplasia; Hypertension / physiopathology; Models, Cardiovascular; Muscle, Smooth, Vascular / pathology; Muscle, Smooth, Vascular / physiopathology; Pulsatile Flow / physiology; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR: The focus is on the identification of susceptible sites in branching blood vessels and their subsequent redesign, employing hemodynamic wall parameters that indicate susceptible sites of intimal thickening and/or favorable conditions for thrombi formation. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2000 article

Computational analyses and design improvements of graft-to-vein anastomoses

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 141–147.

By: P. Longest n, C. Kleinstreuer n & P. Andreotti

author keywords: hemodialysis; graft failure; hemodynamic simulations; geometric designs
MeSH headings : Arteriovenous Shunt, Surgical / methods; Blood Flow Velocity; Computer Simulation; Hemodynamics; Humans; Models, Cardiovascular; Renal Dialysis / methods
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2000 journal article

Computational haemodynamics analysis and comparison study of arterio-venous grafts

Journal of Medical Engineering & Technology, 24(3), 102–110.

By: P. Longest & C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Turbulent three-dimensional air flow and trace gas distribution in an inhalation test chamber

Longest, P. W., Kleinstreuer, C., & Kinsey, J. S. (2000, June). JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 122, pp. 403–411.

By: P. Longest n, C. Kleinstreuer n & J. Kinsey *

TL;DR: Steady incompressible turbulent air flow and transient carbon monoxide transport in an empty Rochester-style human exposure chamber have been numerically simulated and compared with experimental data sets to determine the development of tracer gas distributions in the chamber and analyze the contributions to CO-mixing. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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