Works (1)
Updated: June 12th, 2023 22:48
2000 journal article
C-terminal alternative splicing changes the gating properties of a human spinal cord calcium channel alpha 1A subunit
Journal of Neuroscience, 20(20), 7564–7570.
MeSH headings : Alternative Splicing; Amino Acid Substitution; Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Cells, Cultured; Cerebellum / metabolism; Exons; Gene Expression; Humans; Ion Channel Gating / genetics; Membrane Potentials / physiology; Microinjections; Molecular Sequence Data; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oocytes / metabolism; Patch-Clamp Techniques; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Spinal Cord / metabolism; Xenopus
TL;DR:
It is demonstrated that C-terminal structural changes alone can influence the way in which α1A subunits respond to a depolarizing stimulus and add to the developing picture of the C terminus as a critical domain in the regulation of Ca2+ channel function.
(via Semantic Scholar)
open access via www.jneurosci.org (publisher PDF)
Source: NC State University Libraries
Added: August 6, 2018
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