Xueyan Mu

Works (7)

Updated: July 5th, 2023 16:01

2005 journal article

Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 24(1), 146–152.

By: X. Mu n, C. Rider n, G. Hwang n, H. Hoy n & G. LeBlanc n 

author keywords: crustacean; pollutant; reproduction; steroid; terpenoid
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Dose-Response Relationship, Drug; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Juvenile Hormones / physiology; Molting / drug effects; Phenols / antagonists & inhibitors; Phenols / toxicity; Sex Differentiation / drug effects; Signal Transduction / drug effects; Time; Water Pollutants, Chemical / toxicity
TL;DR: It is demonstrated that bisphenol A is chronically toxic to daphnids, probably through its ability to interfere with ecdysteroid/juvenoid regulated processes, however, effects are elicited at levels that are not likely to pose environmental concern. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 301A(10), 793–801.

By: X. Mu n & G. Leblanc n 

MeSH headings : Animals; Cell Proliferation / drug effects; Cells, Cultured; DNA Primers; Daphnia / drug effects; Daphnia / embryology; Daphnia / metabolism; Drosophila; Ecdysteroids / metabolism; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Fatty Acids, Unsaturated / toxicity; Gene Expression Regulation / drug effects; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / toxicity; Models, Biological; Phenylcarbamates / toxicity; Pyridines / toxicity; Pyrimidines / metabolism; RNA, Messenger / metabolism; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Sex Determination Processes; Signal Transduction / physiology; Testosterone / metabolism
TL;DR: Results demonstrated that juvenoids elicit anti-ecdysteroidal activity in a crustacean through a unique mechanism of action. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Synergistic interaction of endocrine-disrupting chemicals: Model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 23(4), 1085–1091.

By: X. Mu n & G. LeBlanc n 

author keywords: endocrine; disruptors; invertebrate; mixtures; synergy
MeSH headings : Algorithms; Animals; Daphnia / growth & development; Daphnia / physiology; Drug Interactions; Ecdysteroids / biosynthesis; Embryonic Development; Endocrine System / drug effects; Environmental Pollutants / toxicity; Fungicides, Industrial / toxicity; Models, Theoretical; Pyrimidines / toxicity; Risk Assessment; Testosterone / pharmacology
TL;DR: The hypothesis that combined exposure to chemicals that inhibit hormone synthesis and that function as hormone receptor antagonists would result in greater‐than‐additive toxicity is tested and it is demonstrated that some endocrine toxicants can synergize, and this synergy can be accurately predicted. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11) - Endocrine disrupters

Marine Environmental Research, 54(3-5), 741–754.

By: X. Mu, C. Rider & G. Leblanc 

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 129(2), 127–133.

By: X. Mu n & G. LeBlanc n 

MeSH headings : Animals; Crustacea / drug effects; Crustacea / embryology; Crustacea / growth & development; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Gonadal Steroid Hormones / poisoning; Molting / drug effects; Testosterone / poisoning
TL;DR: It is demonstrated that ecdysteroids regulate critical processes in daphnid embryo development and testosterone elicits embryo toxicity todaphnids by interfering with Ecdysteroid activity, and that ecdysone receptor antagonism could be one mechanism by which testosterone elicited these effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 292(3), 287–292.

By: X. Mu n & G. LeBlanc n 

MeSH headings : Animals; Congenital Abnormalities / physiopathology; Congenital Abnormalities / veterinary; Daphnia / embryology; Ecdysone / antagonists & inhibitors; Female; Fertility; Fungicides, Industrial / pharmacology; Molting / physiology; Pyrimidines / pharmacology
TL;DR: It is demonstrated that ecdysteroids are critical to normal crustacean embryo development and environmental antiecdysteroidal activity may provide a means by which environmental chemicals impact crustaceans species while not affecting vertebrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1133–1138.

By: G. LeBlanc* , X. Mu* & C. Rider

author keywords: androgens; crustacean; Daphnia magna; development; embryo; invertebrate; 4-nonylphenol; steroids; testosterone; toxicity
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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