@article{hiebel_comins_2015, title={Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry}, volume={71}, ISSN={["0040-4020"]}, DOI={10.1016/j.tet.2015.04.086}, abstractNote={A dihydropyridone-mediated approach to the morphine skeleton was investigated. The hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydropyridone functionalization methods. This new approach should be useful in the design of more efficient syntheses of morphine and its derivatives.}, number={39}, journal={TETRAHEDRON}, author={Hiebel, Anne-Cecile and Comins, Daniel L.}, year={2015}, month={Sep}, pages={7354–7360} } @article{comins_hiebel_2005, title={Asymmetric synthesis of 3,3-disubstituted isoindolinones}, volume={46}, ISSN={["0040-4039"]}, DOI={10.1016/j.tetlet.2005.06.105}, abstractNote={An anionic chiral auxiliary-mediated asymmetric alkylation of carbamate 2 affords 3,3-disubstituted isoindolinones 3 in moderate to high de. The chiral auxiliary can be removed and recovered under mild conditions, and the resulting enantiopure lactams further elaborated.}, number={34}, journal={TETRAHEDRON LETTERS}, author={Comins, DL and Hiebel, AU}, year={2005}, month={Aug}, pages={5639–5642} } @article{comins_hiebel_huang_2001, title={Synthesis and reactivity of N-acyl-5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones}, volume={3}, ISSN={["1523-7052"]}, DOI={10.1021/ol015529v}, abstractNote={[structure: see text]. The Nozaki-Hiyama-Kishi reaction was used to prepare the 5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones 3. Reduction, oxidation, and substitution reactions of 3 were examined.}, number={5}, journal={ORGANIC LETTERS}, author={Comins, DL and Hiebel, AC and Huang, SL}, year={2001}, month={Mar}, pages={769–771} }