Works (1)
Updated: July 5th, 2023 16:00
2001 journal article
A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses
TOXICOLOGICAL SCIENCES, 62(2), 191–204.
author keywords: physiologically based pharmacokinetic (PBPK); model; methyl tert-butyl ether (MTBE); sensitivity analysis; variability analysis
MeSH headings : Administration, Inhalation; Dose-Response Relationship, Drug; Female; Humans; Male; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacokinetics; Models, Biological; Sensitivity and Specificity
TL;DR:
By incorporating an understanding of the metabolic processes, this PBPK model can be used to predict blood levels of MTBE, which is important in determining target tissue dose estimates for risk assessment.
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Added: August 6, 2018
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