@article{pressler_williams_ramos-vara_anderson_2009, title={Sequencing of the Von Hippel-Lindau Gene in Canine Renal Carcinoma}, volume={23}, ISSN={["1939-1676"]}, DOI={10.1111/j.1939-1676.2009.0310.x}, abstractNote={Similarities in human and canine renal cell carcinoma (RCC) epidemiology and biologic behavior suggest that molecular mechanisms of tumorigenesis may be similar in both species. Approximately 75% of RCC in people are of the clear cell subtype, up to 85% of which are associated with mutation of the von Hippel-Lindau (VHL) gene. The canine VHL coding deoxyribonucleic acid (DNA) shares 90% identity with the human VHL gene.To determine whether or not RCC in dogs are associated with VHL mutations, and if so determine the prevalence, type, and location of these mutations.Thirteen dogs with RCC, 2 dogs with primary renal sarcomas, and 10 dogs without neoplastic kidney disease.DNA was extracted from paraffin-embedded RCC tissue; DNA extracts from paraffin-embedded and snap-frozen nonneoplastic canine kidneys and canine whole blood were used as negative controls. Polymerase chain reaction and sequencing of the 3 VHL exons was performed, and results compared with the accessioned canine sequence.All VHL exons were amplified from 9 of 13 canine RCC samples, both renal sarcomas, 8 of 10 nonneoplastic kidney samples, and canine whole blood; only exon 2 could be amplified from 2 RCC samples. Mutations were not identified in any exons. A maximal prevalence of 33.6% for VHL mutations in canine RCC was determined.Although similarities between canine and human RCC merit further investigation of the dog as a model for some subtypes of renal tumors, the lower prevalence of VHL mutations suggests that oncogenesis in these 2 species differs.}, number={3}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Pressler, B. M. and Williams, L. E. and Ramos-Vara, J. A. and Anderson, K. I.}, year={2009}, pages={592–597} }
 @article{allenspach_lomas_wieland_harris_pressler_mancho_lees_vaden_2008, title={Evaluation of perinuclear anti-neutrophilic cytoplasmic autoantibodies as an early marker of protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers}, volume={69}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.69.10.1301}, abstractNote={To evaluate perinuclear anti-neutrophilic cytoplasmic autoantibody (pANCA) status in Soft Coated Wheaten Terriers (SCWTs) and SCWT-Beagle crossbred dogs and to correlate pANCA status of dogs with clinicopathologic variables of protein-losing enteropathy (PLE), protein-losing nephropathy (PLN), or both.13 SCWTs and 8 SCWT-Beagle crossbred dogs in a research colony and a control group comprising 7 dogs with X-linked hereditary nephropathy and 12 healthy SCWTs > 9 years old.Samples were obtained from dogs in the research colony every 6 months. At each sample-collection time point, serum concentrations of albumin, globulin, creatinine, and urea nitrogen; fecal concentration of alpha-proteinase inhibitor; and urinary protein-to-creatinine ratios were determined and correlated with pANCA status.20 of 21 dogs in the research colony had positive results for pANCAs at a minimum of 2 time points, and 18 of 21 dogs had definitive evidence of disease. None of the control dogs had positive results for pANCAs. A positive result for pANCAs was significantly associated with hypoalbuminemia, and pANCAs preceded the onset of hypoalbuminemia on an average of 2.4 years. Sensitivity and specificity for use of pANCAs to predict development of PLE or PLN were 0.95 (95% confidence interval, 0.72 to 1.00) and 0.8 (95% confidence interval, 0.51 to 0.95), respectively.Most dogs in this study affected with PLE, PLN, or both had positive results for pANCAs before clinicopathologic evidence of disease was detected. Thus, pANCAs may be useful as an early noninvasive test of disease in SCWTs.}, number={10}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Allenspach, Karin and Lomas, Bethany and Wieland, Barbara and Harris, Tonya and Pressler, Barrak and Mancho, Carolina and Lees, George E. and Vaden, Shelly L.}, year={2008}, month={Oct}, pages={1301–1304} }
 @article{pesteanu-somogyi_radzai_pressler_2006, title={Prevalence of feline infectious peritonitis in specific cat breeds}, volume={8}, ISSN={["1532-2750"]}, DOI={10.1016/j.jfms.2005.04.003}, abstractNote={Although known that purebreed cats are more likely to develop feline infectious peritonitis (FIP), previous studies have not examined the prevalence of disease in individual breeds. All cats diagnosed with FIP at a veterinary teaching hospital over a 16-year period were identified. Breed, sex and reproductive status of affected cats were compared to the general cat population and to mixed breed cats evaluated during the same period. As with previous studies sexually intact cats and purebreed cats were significantly more likely to be diagnosed with FIP; males and young cats also had a higher prevalence of disease. Abyssinians, Bengals, Birmans, Himalayans, Ragdolls and Rexes had a significantly higher risk, whereas Burmese, Exotic Shorthairs, Manxes, Persians, Russian Blues and Siamese cats were not at increased risk for development of FIP. Although additional factors doubtlessly influence the relative prevalence of FIP, this study provides additional guidance when prioritizing differentials in ill purebreed cats.}, number={1}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Pesteanu-Somogyi, LD and Radzai, C and Pressler, BM}, year={2006}, month={Feb}, pages={1–5} }
 @article{pressler_gookin_sykes_wolf_vaden_2005, title={Urinary tract manifestations of protothecosis in dogs}, volume={19}, ISSN={["1939-1676"]}, DOI={10.1892/0891-6640(2005)19<115:UTMOPI>2.0.CO;2}, abstractNote={Records of 13 dogs with systemic infection with Prototheca sp. from 3 veterinary teaching hospitals were reviewed. Acute renal failure secondary to disseminated infection with Prototheca zopfii was diagnosed in 2 dogs. In 1 dog, acute renal failure developed during administration of immunosuppressive drugs for treatment of anterior uveitis. During diagnostic evaluation of this dog, Prototheca sp. organisms were noted in urine sediment and renal biopsy specimens. In the 2nd dog, acute renal failure was diagnosed after treatment for bacterial cystitis. After diagnosis of protothecosis, organisms were successfully isolated by aerobic urine culture. Both dogs with acute renal failure did not respond to conventional medical therapy. In total, Prototheca sp. was noted in urine sediment in 4 of 8 dogs and successfully cultured from urine in 5 of 7 dogs. Four of 5 dogs had organisms noted in the kidneys on histopathologic examination. In all dogs, the species identified was P zopfii. Sensitivity testing of 3 isolates revealed wide differences in in vitro drug resistance. Examination and culture of urine is recommended as a practical method for diagnosis of systemic infection with Prototheca sp.}, number={1}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Pressler, BM and Gookin, JL and Sykes, JE and Wolf, AM and Vaden, SL}, year={2005}, pages={115–119} }
 @article{vaden_pressler_lappin_jensen_2004, title={Effects of urinary tract inflammation and sample blood contamination on urine albumin and total protein concentrations in canine urine samples}, volume={33}, ISSN={["0275-6382"]}, DOI={10.1111/j.1939-165X.2004.tb00343.x}, abstractNote={Background: Urinary tract inflammation and hemorrhage are believed to be common causes of proteinuria in dogs based on results of studies that measured total urine protein concentration. A method to quantify urine albumin (UAlb) concentration in dogs recently has become available; however, the effect of inflammation on albuminuria is unknown. Objectives: The goals of this study were to determine the effects of urinary tract inflammation, as indicated by pyuria and sample blood contamination, on UAlb concentration and on urine protein: creatinine (UPC) ratio in dogs. Methods: Urine samples were obtained from dogs with pyuria that were presented to a veterinary teaching hospital or were part of a laboratory colony. To mimic the effects of hematuria, canine whole blood was added to a microscopically normal canine urine sample that had baseline albumin and total protein concentrations below the limits of detection. UAlb concentration was measured using a canine albumin-specific competitive ELISA. UPC ratio was determined using routine methods. Results: Of 70 samples with pyuria, 67% had negligible UAlb concentrations and 81% had normal UPC ratios. UAlb concentration but not UPC ratio was significantly higher (P < 0.05) in samples with concurrent hematuria or bacteriuria. When whole blood was added to normal urine, UAlb concentration did not exceed 1 mg/dL until the sample became visibly pink; the UPC did not exceed 0.4 at any dilution. Conclusions: Many dogs with pyuria do not have albuminuria or proteinuria; however, albuminuria may be more likely in dogs with pyuria and concurrent hematuria or bacteriuria. Hematuria may not cause an increase in UAlb concentration until it becomes macroscopic and even then may not increase the UPC ratio.}, number={1}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Vaden, SL and Pressler, BM and Lappin, MR and Jensen, WA}, year={2004}, pages={14–19} }
 @article{pressler_mohammadian_li_vaden_levine_mathews_robertson_2004, title={In vitro prediction of canine urolith mineral composition using computed tomographic mean beam attenuation measurements}, volume={45}, ISSN={1058-8183 1740-8261}, url={http://dx.doi.org/10.1111/j.1740-8261.2004.04032.x}, DOI={10.1111/j.1740-8261.2004.04032.x}, abstractNote={Determination of urolith mineral composition is critical for management of urolithiasis in dogs and cats. Using computed tomography, urolith physical density, and hence chemical composition, can be quantified using mean beam attenuation measurements (Hounsfield units; HU). This study was designed to establish in vitro reference ranges for three types of compositionally pure uroliths retrieved from dogs. Sixty-six canine uroliths (22 uric acid, 21 calcium oxalate, 14 struvite, nine mixed or compound) were placed in a phantom array. Uroliths were scanned at 120 kVp, 200 mA, and 80 kVp, 200 mA. The region of interest (ROI) for mean HU calculation was determined using two techniques, and reference ranges were calculated for each kVp using either ROI technique. HU for urolith types of pure composition were statistically different (Wilcoxon's two-sample test, P < 0.0083 [Bonferonni correction with six comparisons for total P < 0.05]) using both ROI techniques at either kVp. Struvite uroliths were not statistically different from mixed or compound uroliths. The accuracy for determination of composition of pure uroliths ranged from 86% to 93%; the prediction accuracy for each urolith mineral type and for all uroliths in general was highest when the ROI was hand-drawn just within the visible urolith border at 80 kVp. Technique of ROI determination and kVp that yielded the highest sensitivity, specificity, and positive and negative predictive values varied for each urolith type. Therefore, in this study, HU could be used to differentiate three types of uroliths of pure mineral composition in vitro. Further studies are needed to determine the predictive value of HU in vivo.}, number={3}, journal={Veterinary Radiology <html_ent glyph="@amp;" ascii="&"/> Ultrasound}, publisher={Wiley}, author={Pressler, Barrak M. and Mohammadian, Lenore A. and Li, Erning and Vaden, Shelly L. and Levine, Jay F. and Mathews, Kyle G. and Robertson, Ian D.}, year={2004}, month={May}, pages={189–197} }
 @article{pressler_vaden_lane_cowgill_dye_2003, title={Candida spp. urinary tract infections in 13 dogs and seven cats: Predisposing factors, treatment, and outcome}, volume={39}, ISSN={["0587-2871"]}, DOI={10.5326/0390263}, abstractNote={Records from 20 animals (13 dogs, seven cats) with Candida spp. urinary tract infections were reviewed. Six Candida spp. were isolated; Candida albicans was the most common isolate. Concurrent diseases or nonantifungal drugs administered within 1 month of isolation included antibiotics (n=16), corticosteroids (n=6), diabetes mellitus (n=4), nonurogenital neoplasia (n=3), and noncandidal urogenital disease (n=14). All animals had sources of local or systemic immune compromise that likely predisposed to infection. Of five animals with resolution of infection, three did not receive specific antifungal treatment. The authors conclude that correction of predisposing conditions is likely critical for management of Candida spp. urinary tract infection.}, number={3}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Pressler, BM and Vaden, SL and Lane, IF and Cowgill, LD and Dye, JA}, year={2003}, pages={263–270} }
 @article{frey_pressler_guy_pitulle_breitschwerdt_2003, title={Capnocytophaga sp. Isolated from a Cat with Chronic Sinusitis and Rhinitis}, volume={41}, ISSN={0095-1137}, url={http://dx.doi.org/10.1128/jcm.41.11.5321-5324.2003}, DOI={10.1128/JCM.41.11.5321-5324.2003}, abstractNote={ABSTRACT A Capnocytophaga sp. was inadvertently isolated from a cat with chronic sinusitis and rhinitis when cytopathic effects were observed in Crandall-Reese feline kidney cells that had been inoculated with oropharyngeal swab samples. Although Capnocytophaga spp. are of considerable zoonotic importance, their clinical relevance for dogs or cats has not been established. However, failure to do so may be attributed to the infrequent use of specialized isolation techniques that are required to grow Capnocytophaga spp. To our knowledge, successful isolation of these organisms from a cat with nasopharyngeal disease has not been reported.}, number={11}, journal={Journal of Clinical Microbiology}, publisher={American Society for Microbiology}, author={Frey, E. and Pressler, B. and Guy, J. and Pitulle, C. and Breitschwerdt, E.}, year={2003}, month={Nov}, pages={5321–5324} }
 @article{pressler_goodman_harms_hawkins_lewbart_2003, title={Endoscopic evaluation of the esophagus and stomach in three loggerhead sea turtles (Caretta caretta) and a Malaysian giant turtle (Orlitia borneensis).}, volume={34}, DOI={10.1638/1042-7260(2003)34[0088:eeotea]2.0.co;2}, abstractNote={Three loggerhead sea turtles (Caretta caretta) and a Malaysian giant turtle (Orlitia borneensis) were presented with suspected or confirmed esophageal foreign bodies. Esophagoscopy was performed on all turtles, and gastroscopy was performed on three turtles. In all cases, endoscopy was easy to perform, and allowed visualization of most upper gastrointestinal features. The papillated esophagus was easy to navigate, but mucosal papillae in the loggerhead sea turtles prevented examination of the underlying mucosa. The stomach was easily entered and examined in both species, but the working endoscope length (100 cm) prevented inspection of the pyloric antrum and the duodenum in all turtles. The turtles in this report may serve as references for future endoscopic examinations of these species.}, number={1}, journal={Journal of Zoo and Wildlife Medicine}, author={Pressler, B. M. and Goodman, R. A. and Harms, Craig and Hawkins, Eleanor and Lewbart, Gregory}, year={2003}, pages={88–92} }
 @article{pressler_vaden_2003, title={Managing renal amyloidosis in dogs and cats}, volume={98}, number={4}, journal={Veterinary Medicine}, author={Pressler, B. M. and Vaden, S. L.}, year={2003}, pages={320-} }
 @article{pressler_vaden_jensen_simpson_2002, title={Detection of canine microalbuminuria using semiquantitative test strips designed for use with human urine}, volume={31}, ISSN={["0275-6382"]}, DOI={10.1111/j.1939-165X.2002.tb00280.x}, abstractNote={Commercial testing for microalbuminuria in human urine is often performed with point-of-care semiquantitative test strips followed by quantitative testing when indicated. An ELISA that quantifies canine urine albumin concentration has been developed, but semiquantitative test strips for use in the dog are not available.The purpose of this study was to prospectively determine the concordance of canine urine albumin concentrations measured by a commercial human test strip and by ELISA.Urine samples were obtained from 67 dogs evaluated for a variety of clinical conditions. Dipstick urinalyses were performed on all samples; clinician discretion determined method of urine collection and performance of urine sediment examination and/or urine culture. Urine albumin concentration was determined using test strips (Clinitek Microalbumin, Bayer Corporation, Elkhart, Ind, USA), and results were compared with those obtained by ELISA.The Clinitek strips correctly determined albumin concentration in 42 of 67 (63%) urine samples tested. Concordance was lowest (48%) for dogs with microalbuminuria (10-300 microg/mL by ELISA). Clinitek strip sensitivity and specificity for correct identification of microalbuminuria were 48% and 75%, respectively. Concordance was lower in dogs with urinary tract infection or hematuria and in samples collected by catheterization. Sensitivity and specificity for correct identification of microalbuminuria after exclusion of dogs with urinary tract infection or hematuria were 59% and 83%, respectively.These results suggest that the Clinitek strips lack sufficient concordance with results obtained by ELISA to be a reliable screening for test microalbuminuria in the dog. A reliable semiquantitative point-of-care test for canine urine albumin concentrations below those detected by standard urine dipsticks is still needed.}, number={2}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Pressler, BM and Vaden, SL and Jensen, WA and Simpson, D}, year={2002}, pages={56–60} }
 @article{pressler_rotstein_law_rosol_leroy_keene_jackson_2002, title={Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog}, volume={221}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2002.221.263}, abstractNote={A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia. No metastases were identified during antemortem evaluation, but severe hypercalcemia was evident. Antemortem diagnostic testing failed to identify a cause for the hypercalcemia. No neoplasms other than the melanoma were identified on postmortem examination. Serum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. Paraneoplastic syndromes are rare in dogs with malignant melanoma.}, number={2}, journal={JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Pressler, BM and Rotstein, DS and Law, JM and Rosol, TJ and LeRoy, B and Keene, BW and Jackson, MW}, year={2002}, month={Jul}, pages={263-+} }
 @article{pressler_hardie_pitulle_hopwood_sontakke_breitschwerdt_2002, title={Isolation and identification of Mycobacterium kansasii from pleural fluid of a dog with persistent pleural effusion}, volume={220}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.2002.220.1336}, DOI={10.2460/javma.2002.220.1336}, abstractNote={A 3-year-old spayed female Whippet was examined for cough and respiratory distress. Lung lobe torsion with pleural effusion was diagnosed, and lung lobectomy was performed. Pleural effusion recurred during the following 27 months; conventional bacteriologic cultures of pleural effusion did not result in bacterial growth. A second lung lobectomy, pleuroperitoneal shunt placement. and pericardectomy were subsequently performed. Mycobacterium kansasii was eventually isolated from pleural fluid and identified by polymerase chain reaction amplification and DNA sequencing. The dog was euthanatized before therapeutic response could be evaluated. To our knowledge, this is the first report of M. kansasii infection in a dog. Additionally, this is the first report of mycobacterial isolation from pleural fluid, and one of few reports of antemortem mycobacterial isolation from a body fluid, as opposed to identification in specimens during histologic examination. Routine bacteriologic culture methods are insufficient to isolate mycobacterial agents, and special methods are indicated in dogs with persistent pleural effusion.}, number={9}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Pressler, Barrak M. and Hardie, Elizabeth M. and Pitulle, Christian and Hopwood, Robin M. and Sontakke, Sushama and Breitschwerdt, Edward B.}, year={2002}, month={May}, pages={1336–1340} }
 @article{thomas_pressler_robertson_2001, title={Radiographic diagnosis - Polyostotic lymphoma in a 5 month old dog}, volume={42}, ISSN={["1058-8183"]}, DOI={10.1111/j.1740-8261.2001.tb00980.x}, abstractNote={Veterinary Radiology & UltrasoundVolume 42, Issue 6 p. 521-523 RADIOGRAPHIC DIAGNOSIS—POLYOSTOTIC LYMPHOMA IN A 5 MONTH OLD DOG Helen L. Thomas BVMS, MSPVM, DVSc, Helen L. Thomas BVMS, MSPVM, DVSc Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorBarrak M. Pressler DVM, Barrak M. Pressler DVM Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorIan D. Robertson BVSc, Corresponding Author Ian D. Robertson BVSc Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Address correspondence and reprint requests to Dr. RobertsonSearch for more papers by this author Helen L. Thomas BVMS, MSPVM, DVSc, Helen L. Thomas BVMS, MSPVM, DVSc Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorBarrak M. Pressler DVM, Barrak M. Pressler DVM Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorIan D. Robertson BVSc, Corresponding Author Ian D. Robertson BVSc Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Address correspondence and reprint requests to Dr. RobertsonSearch for more papers by this author First published: 19 May 2005 https://doi.org/10.1111/j.1740-8261.2001.tb00980.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume42, Issue6November 2001Pages 521-523 RelatedInformation}, number={6}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Thomas, HL and Pressler, BM and Robertson, ID}, year={2001}, pages={521–523} }