Works (10)
Updated: July 5th, 2023 16:03
2001 journal article
Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 24(5), 303–308.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chickens; Chromatography, High Pressure Liquid; Ciprofloxacin / administration & dosage; Ciprofloxacin / analogs & derivatives; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Fluoroquinolones; Half-Life; Injections, Intramuscular; Injections, Intravenous; Male; Metabolic Clearance Rate; Species Specificity; Swine; Tissue Distribution
TL;DR:
Sarafloxacin was demonstrated to be more rapidly absorbed, more extensively distributed, and more quickly eliminated in broilers than in pigs and to maintain effective plasma concentrations with bacteria infections, in which MIC90 are <0.25 microg/mL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Dermal absorption and tissue disposition of 3,3',4,4'-tetrachlorobiphenyl (TCB) in an ex vivo pig model: Assessing the impact of dermal exposure variables
International Journal of Occupational and Environmental Health, 6, 127–137.
MeSH headings : Animals; Female; Linear Models; Pharmaceutical Vehicles; Pharmacokinetics; Polychlorinated Biphenyls / metabolism; Skin / drug effects; Skin Absorption; Soil Pollutants / metabolism; Swine
TL;DR:
Dermal absorption data from liquid-organic or aqueousorganic mixtures may underestimate the risk of exposure to TCB-contaminated soil.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin
Toxicology Letters, 93(2-3), 159–169.
Contributors: R. Baynes n , N. Monteiro-Riviere n , n & J. Riviere n
author keywords: chemical mixtures; cutaneous toxicity; benzidine dye
MeSH headings : Animals; Benzidines / pharmacokinetics; Benzidines / toxicity; Biomarkers; Coloring Agents / pharmacokinetics; Coloring Agents / toxicity; Dermotoxins / adverse effects; Dermotoxins / pharmacokinetics; Hazardous Waste / adverse effects; In Vitro Techniques; Perfusion; Skin Absorption; Solvents / pharmacokinetics; Solvents / toxicity; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine; Toxicity Tests
TL;DR:
It is demonstrated that various mixtures, especially those containing SLS alter the epidermal barrier differently with complex interactions occurring simultaneously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1997 journal article
Pentachlorophenol dermal absorption and disposition from soil in swine: Effects of occlusion and skin microorganism inhibition
TOXICOLOGY AND APPLIED PHARMACOLOGY, 147(2), 234–246.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Carbon Radioisotopes; Female; Pentachlorophenol / metabolism; Pesticides / metabolism; Skin / drug effects; Skin / metabolism; Skin / microbiology; Skin Absorption; Soil; Soil Pollutants / metabolism; Swine
TL;DR:
Significant dermal absorption and extensive tissue persistence of PCP after soil exposure is demonstrated and exposure-specific PCP absorption and disposition profiles must be taken into consideration in risk analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 report
Percutaneous absorption of volatile chemicals
In (NTIS report AFOSR G49620-95-1-0017) (pp. 1–23).
TL;DR:
These studies demonstrated dose-dependent absorption of CPFB and DCB in skin which was further modulated by concomitant exposure to vehicle, and could be used as direct input into a systemic risk assessment model.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .1. Studies with parathion mixtures in isolated perfused porcine skin
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 473–486.
Contributors: n, J. Brooks n, R. Baynes n, N. MonteiroRiviere n, P. Williams n & J. Riviere n
MeSH headings : Animals; Dimethyl Sulfoxide / pharmacology; Female; Insecticides / pharmacokinetics; Parathion / pharmacokinetics; Perfusion; Risk Assessment; Skin / blood supply; Skin / metabolism; Skin Absorption; Surface-Active Agents / pharmacology; Swine
TL;DR:
This study indicated multiple levels of interactive effects on PA absorption which must be incorporated into any effort to identify critical mechanisms which affect risk assessment of topically exposed mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess mixture component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .2. Development of a general dermatopharmacokinetic model for use in risk assessment
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 487–496.
Contributors: P. Williams n, D. Thompson n, n, N. MonteiroRiviere n & J. Riviere n
MeSH headings : Animals; Models, Biological; Perfusion; Risk Assessment; Skin / metabolism; Skin Absorption; Swine
TL;DR:
This model supports the MDCM concept that defining and then simulating those components of a complex mixture that could have a significant impact on the absorption of a marker toxic compound would be a useful screening approach in the risk assessment of topical chemical mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
Significant Effects of Application Site and Occlusion on the Pharmacokinetics of Cutaneous Penetration and Biotransformation of Parathion in Vivo in Swine
Journal of Pharmaceutical Sciences, 84(4), 425–432.
MeSH headings : Adipose Tissue / metabolism; Administration, Topical; Animals; Biotransformation; Epidermis / metabolism; Female; Half-Life; Injections, Intravenous; Models, Biological; Parathion / administration & dosage; Parathion / pharmacokinetics; Skin Absorption / physiology; Swine
TL;DR:
Systemic bioavailability of PA was higher from the back than from the abdomen, and Occlusion not only increased the amount of 14C absorption and shortened the mean residence time in most compartments but also altered the systemic versus cutaneous biotransformation pattern.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1994 journal article
Percutaneous absorption, biotransformation and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model
Drug Metabolism and Disposition, 22, 459–471.
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
Effects of Anatomical Site and Occlusion on the Percutaneous Absorption and Residue Pattern of 2,6-(ring-14C)Parathion in Vivo in Pigs
Toxicology and Applied Pharmacology, 122(1), 131–138.
MeSH headings : Abdomen; Administration, Topical; Animals; Back; Buttocks; Drug Residues; Feces / chemistry; Female; Injections, Intravenous; Parathion / administration & dosage; Parathion / pharmacokinetics; Parathion / toxicity; Shoulder; Skin Absorption; Swine; Tissue Distribution
TL;DR:
The effects of anatomical site and occlusion on the percutaneous absorption and residue pattern of total 14C were investigated following topical application of 2,6-[ring-14C]parathion onto four skin sites in weanling swine using occluded and nonoccluded dosing systems, with shoulder and buttocks being similar, and the back the highest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
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