Works (6)

Updated: July 6th, 2023 15:15

2011 journal article

Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium

BMC MICROBIOLOGY, 11.

By: M. Evans n, R. Fink n, A. Vazquez-Torres*, S. Porwollik*, J. Jones-Carson*, M. McClelland*, H. Hassan n

MeSH headings : Anaerobiosis; Animals; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Metabolic Networks and Pathways / genetics; Mice; Mice, Inbred C57BL; Microarray Analysis; Regulon; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / growth & development; Salmonella typhimurium / metabolism
TL;DR: The results demonstrated that in S. Typhimurium, ArcA serves as a transcriptional regulator coordinating cellular metabolism, flagella biosynthesis, and motility, and a set of 120 genes whose regulation was shared with the anaerobic redox regulator, Fnr. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Fur Negatively Regulates hns and Is Required for the Expression of HilA and Virulence in Salmonella enterica Serovar Typhimurium

JOURNAL OF BACTERIOLOGY, 193(2), 497–505.

By: B. Troxell n, M. Sikes n, R. Fink n, A. Vazquez-Torres*, J. Jones-Carson* & H. Hassan n

MeSH headings : Animals; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Chromatin Immunoprecipitation; DNA, Bacterial / metabolism; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / metabolism; Disease Models, Animal; Gene Expression Regulation, Bacterial; Gene Knockout Techniques; Genes, Bacterial; Genomic Islands; Mice; Mice, Inbred C3H; Operon; Protein Binding; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / pathogenicity; Salmonella typhimurium / physiology; Survival Analysis; Trans-Activators / biosynthesis; Transcription Factors / biosynthesis; Virulence; Virulence Factors / biosynthesis
TL;DR: Fur is required for virulence in Salmonella enterica serovar Typhimurium and that Fur is necessary for the activation of hilA, as well as of other HilA-dependent genes, invF and sipC, and chromatin immunoprecipitation was used to show that Fur bound to the upstream region of hns in a metal-dependent fashion. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets

BMC MICROBIOLOGY, 11.

By: B. Troxell n, R. Fink n, S. Porwollik*, M. McClelland* & H. Hassan n

MeSH headings : Anaerobiosis; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression Regulation, Bacterial; Iron / metabolism; Oxygen / metabolism; Regulon; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / metabolism
TL;DR: This work identified twenty-six new targets of Fur regulation, and demonstrates that H-NS repressed genes are down-regulated in Δfur, indicating that Fur is a positive factor in ftnB regulation, while serving to repress the expression of hmpA. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar typhimurium (ATCC 14028s)

JOURNAL OF BACTERIOLOGY, 189(6), 2262–2273.

By: R. Fink n, M. Evans n, S. Porwollik*, A. Vazquez-Torres*, J. Jones-Carson*, B. Troxell n, S. Libby*, M. McClelland*, H. Hassan n

MeSH headings : Anaerobiosis; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cells, Cultured; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli Proteins / genetics; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Iron-Sulfur Proteins / genetics; Iron-Sulfur Proteins / metabolism; Macrophages, Peritoneal / microbiology; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Oligonucleotide Array Sequence Analysis; Salmonella Infections / microbiology; Salmonella Infections / pathology; Salmonella typhimurium / genetics; Salmonella typhimurium / growth & development; Salmonella typhimurium / metabolism; Salmonella typhimurium / pathogenicity; Transcription Factors / genetics; Transcription Factors / metabolism; Virulence
TL;DR: The role of FNR as a positive regulator of motility, flagellar biosynthesis, and pathogenesis was confirmed by showing that the isogenic fnr mutant is nonmotile, lacks flagella, is attenuated in mice, and does not survive inside macrophages. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Genetic markers unique to Listeria monocytogenes serotype 4b differentiate epidemic clone II (hot dog outbreak strains) from other lineages

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(4), 2383–2390.

By: M. Evans n, B. Swaminathan*, L. Graves*, E. Altermann n, T. Klaenhammer n, R. Fink n, S. Kernodle n, S. Kathariou n

MeSH headings : Animals; Base Sequence; DNA Primers / genetics; DNA, Bacterial / genetics; Disease Outbreaks; Europe / epidemiology; Food Microbiology; Foodborne Diseases / epidemiology; Foodborne Diseases / microbiology; Genes, Bacterial; Genetic Markers; Humans; Listeria monocytogenes / classification; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Meat Products / microbiology; North America / epidemiology; Polymerase Chain Reaction; Serotyping
TL;DR: The findings suggest that ECII strains have undergone divergence in portions of a serotype-specific region that is conserved in other serotype 4b strains, although the mechanisms that drive this divergence remain to be identified. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Molecular evolution and structure-function relationships of the superoxide dismutase gene families in angiosperms and their relationship to other eukaryotic and prokaryotic superoxide dismutases

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 399(1), 19–36.

By: R. Fink n & J. Scandalios n

author keywords: SOD,superoxide dismutase protein or isozyme; Sod, superoxide dismutase gene or transcript; molecular evolution; phylogenetic tree; gene structure and function; Zea mays L. (maize); antioxidant genes; oxidative stress; reactive oxygen species (ROS)
MeSH headings : Amino Acid Sequence; Animals; Eukaryotic Cells / enzymology; Evolution, Molecular; Genes, Plant; Humans; Introns; Magnoliopsida / enzymology; Models, Molecular; Molecular Sequence Data; Phylogeny; Prokaryotic Cells / enzymology; Sequence Alignment; Structure-Activity Relationship; Superoxide Dismutase / chemistry; Superoxide Dismutase / genetics; Superoxide Dismutase / physiology; Zea mays / enzymology
TL;DR: The findings suggest that the 5' region of these genes played a pivotal role in the evolution of function of these enzymes, and it is critical to understand the physiological differences between the SODs in response to different stresses in order to compare their functions and evolutionary history. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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