Works (2)

Updated: July 5th, 2023 16:00

2004 journal article

Cortisol rapidly suppresses intracellular calcium and voltage-gated calcium channel activity in prolactin cells of the tilapia (Oreochromis mossambicus)


By: G. Hyde n, A. Seale, E. Grau & R. Borski*

author keywords: BAY K 8644; nongenomic actions; glucocorticoids; osmoregulation; nifedipine; L-type voltage-gated ion channels; teleost
MeSH headings : 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / antagonists & inhibitors; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology; Animals; Anti-Inflammatory Agents / pharmacology; Calcium / metabolism; Calcium Channel Agonists / pharmacology; Calcium Channel Blockers; Calcium Channels, L-Type / drug effects; Calcium Radioisotopes; Cyclic AMP / metabolism; Electrophoresis, Polyacrylamide Gel; Fura-2; Hormone Antagonists / pharmacology; Hydrocortisone / pharmacology; In Vitro Techniques; Ion Channel Gating / drug effects; Ion Channel Gating / physiology; Male; Osmotic Pressure; Pituitary Gland, Anterior / cytology; Pituitary Gland, Anterior / drug effects; Pituitary Gland, Anterior / metabolism; Prolactin / physiology; Somatostatin / pharmacology; Tilapia / physiology
TL;DR: Results indicate that cortisol inhibits tilapia PRL release through rapid reductions in Ca(i)(2+) that likely involve an attenuation of Ca( 2+) entry through L-type voltage-gated Ca(2+) channels. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 article

Signal transduction mechanisms mediating rapid, nongenomic effects of cortisol on prolactin release

Borski, R. J., Hyde, G. N., & Fruchtman, S. (2002, May). STEROIDS, Vol. 67, pp. 539–548.

By: R. Borski n, G. Hyde n & S. Fruchtman n

author keywords: steroid hormone; adenylyl cyclase; calcium; cAMP; nongenomic action; phospholipase C; membrane receptor
MeSH headings : Animals; Calcium / metabolism; Cell Membrane / drug effects; Cell Membrane / metabolism; Cells, Cultured; Cyclic AMP / metabolism; Hydrocortisone / pharmacology; Models, Biological; Osmolar Concentration; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Prolactin / metabolism; Second Messenger Systems / drug effects; Second Messenger Systems / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Tilapia
TL;DR: Findings indicate that the acute inhibitory effects of cortisol on PRL release occur through a nongenomic mechanism involving interactions with the plasma membrane and inhibition of both the Ca(2+) and cAMP signal transduction pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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