Works (28)

Updated: August 2nd, 2023 21:16

2020 journal article

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

JOURNAL OF MOLECULAR BIOLOGY, 432(2), 343โ€“357.

By: M. Miltonโ€‰*, G. Draughn n, B. Bobay n, S. Stowe n, A. Olson n, E. Feldmann n, R. Thompson*, K. Myers n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Biofilms; Bacillus subtilis; Transcriptional regulation; NMR solution structure
MeSH headings : Amino Acid Sequence / genetics; Bacillus subtilis / genetics; Bacillus subtilis / ultrastructure; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / ultrastructure; Biofilms / growth & development; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ultrastructure; Gene Expression Regulation, Bacterial / genetics; Molecular Docking Simulation; Mutation / genetics; Protein Binding / genetics; Protein Conformation
Source: Web Of Science
Added: February 27, 2020

2019 journal article

Translating antibody-binding peptides into peptoid ligands with improved affinity and stability

JOURNAL OF CHROMATOGRAPHY A, 1602, 284โ€“299.

By: T. Bordelon, B. Bobay*, A. Murphy, H. Reese, C. Shanahan, F. Odeh, A. Broussard, C. Kormos, S. Menegatti nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Peptoid ligands; Molecular docking; Affinity chromatography; Antibodies; Protein A mimetic
MeSH headings : Adsorption; Alkalies / chemistry; Amino Acid Sequence; Animals; Antibodies / metabolism; Antibody Affinity; Binding Sites; CHO Cells; Cattle; Cricetinae; Cricetulus; Humans; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Ligands; Molecular Docking Simulation; Peptides / chemistry; Peptoids / chemistry; Protein Binding; Proteolysis; Temperature
Sources: Web Of Science, ORCID
Added: September 16, 2019

2017 journal article

Design, selection, and development of cyclic peptide ligands for human erythropoietin

JOURNAL OF CHROMATOGRAPHY A, 1500, 105โ€“120.

By: W. Kish n, H. Sachi*, A. Naik n, M. Roach n, B. Bobay n, R. Blackburn n, S. Menegatti nโ€‰, R. Carbonell n

co-author countries: Japan ๐Ÿ‡ฏ๐Ÿ‡ต United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

MOLECULAR MICROBIOLOGY, 106(2), 223โ€“235.

By: M. Miltonโ€‰*, C. Allen n, E. Feldmann n, B. Bobay n, D. Jungโ€‰*, M. Stephens n, R. Melander n, K. Theisenโ€‰ n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / ultrastructure; Biofilms / drug effects; Francisella tularensis / metabolism; Gene Expression Regulation, Bacterial / genetics; Imidazoles / metabolism; Imidazoles / pharmacology; Protein Binding; Virulence / drug effects; Virulence Factors / genetics; Virulence Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

MSPHERE, 1(6).

By: M. Moore n, B. Bobay n, B. Mertens n & L. Jaykus n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamer; GII.4; histo-blood group antigen; infectivity; noroviruses
Source: Web Of Science
Added: August 6, 2018

2015 journal article

NMR-based structural analysis of threonylcarbamoyl-AMP synthase and Its substrate interactions

Journal of Biological Chemistry, 290(33), 20032โ€“20043.

By: K. Harris, B. Bobay, K. Sarachan, A. Sims, Y. Bilbille, C. Deutsch, D. Iwata-Reuyl, P. Agris

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

JOURNAL OF MOLECULAR BIOLOGY, 426(9), 1911โ€“1924.

By: A. Tucker n, B. Bobay n, A. Banse*, A. Olson n, E. Soderblom*, M. Moseleyโ€‰*, R. Thompson n, K. Varneyโ€‰*, R. Losick*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: transition state regulator; AbbA; DNA mimic; molecular docking; NMR
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Multimerization
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 177โ€“179.

By: B. Bobay n, R. Thompson n, D. Milton* & J. Cavanagh n

co-author countries: Sweden ๐Ÿ‡ธ๐Ÿ‡ช United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: VanU; NMR; Vibrio anguillarum; Phosphorelay
MeSH headings : Bacterial Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Phosphotransferases / chemistry; Protein Structure, Secondary; Vibrio / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

STRUCTURE, 22(11), 1650โ€“1656.

By: A. Olson n, A. Tucker n, B. Bobay n, E. Soderblom*, M. Moseleyโ€‰*, R. Thompson n, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA, Bacterial / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Secondary; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95โ€“98.

By: A. Olson n, B. Bobay n, C. Melander n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: AbrB; NMR; Bacillus anthracis; Transition state regulator
MeSH headings : Bacillus anthracis; Bacterial Proteins / chemistry; DNA-Binding Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

BIOCHEMISTRY, 51(49), 9776โ€“9778.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

FEBS LETTERS, 586(20), 3582โ€“3589.

By: B. Bobay n, A. Stewart n, A. Tucker n, R. Thompson n, K. Varneyโ€‰* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Calbindin-D28K; Caspase-3; Isothermal titration calorimetry; Molecular docking
MeSH headings : Calbindins; Calcium / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation; Hydrogen Bonding; Molecular Docking Simulation; Protein Binding; Protein Conformation; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271โ€“282.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddimanโ€‰, R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Long range dynamic effects of point-mutations trap a response regulator in an active conformation

FEBS LETTERS, 584(19), 4203โ€“4207.

By: B. Bobay n, R. Thompson n, J. Hoch* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR; Conformational transition; Intra-protein communication; Response regulator; Spo0F
MeSH headings : Bacillus subtilis / genetics; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins / chemistry; Mutant Proteins / genetics; Mutant Proteins / metabolism; Nuclear Magnetic Resonance, Biomolecular; Point Mutation; Principal Component Analysis; Protein Conformation; Second Messenger Systems / genetics; Signal Transduction / genetics; Thermodynamics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A

JOURNAL OF MOLECULAR BIOLOGY, 398(2), 248โ€“263.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: competence; ComA; NMR; two-component; response regulator
MeSH headings : Amino Acid Sequence; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Helix-Turn-Helix Motifs; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Structural Characterization of the Conformational Change in Calbindin-D-28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry

BIOCHEMISTRY, 48(36), 8603โ€“8614.

By: C. Hobbs n, L. Deterdingโ€‰*, L. Pereraโ€‰*, B. Bobay n, R. Thompson n, T. Darden*, J. Cavanagh n, K. Tomer*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Animals; Apoproteins / chemistry; Calbindin 1; Calbindins; Cysteine / chemistry; Disulfides / chemistry; EF Hand Motifs; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Co-Evolving Motions at Proteinโˆ’Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysisโ€ 

Biochemistry, 47(30), 7782โ€“7784.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Analysis of Variance; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; Magnetic Resonance Spectroscopy; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins / chemistry; Proteins / metabolism; Signal Transduction
Sources: Web Of Science, Crossref
Added: August 6, 2018

2008 journal article

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

STRUCTURE, 16(11), 1702โ€“1713.

By: D. Sullivan n, B. Bobay n, D. Kojetinโ€‰*, R. Thompson n, M. Rance*, M. Strauch*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Thermodynamics; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Targeting RNA with cysteine-constrained peptides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565โ€“567.

By: V. Burns n, B. Bobay n, A. Basso n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: RNA; cyclic peptides; HADDOCK
MeSH headings : Base Sequence; Cysteine / chemistry; Humans; Models, Molecular; Peptides, Cyclic / chemistry; RNA / chemistry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Abh and AbrB control of Bacillus subtilis antimicrobial gene expression

JOURNAL OF BACTERIOLOGY, 189(21), 7720โ€“7732.

By: M. Strauch*, B. Bobay n, J. Cavanagh n, F. Yao*, A. Wilson* & Y. Le Bretonโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / genetics; Bacillus subtilis / growth & development; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Binding Sites; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Gene Expression Regulation, Bacterial; Genes, Bacterial; Kinetics; Molecular Sequence Data; Mutation; Plasmids; Transcription Factors / genetics; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Peptide binding proclivities of calcium loaded calbindin-D28k

FEBS LETTERS, 581(24), 4778โ€“4782.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: calbindin-D28k; NMR; chemical shift; peptides; modeling
MeSH headings : Animals; Calbindin 1; Calbindins; Calcium / metabolism; Circular Dichroism; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides / metabolism; Protein Binding; Protein Structure, Tertiary; Rats; S100 Calcium Binding Protein G / metabolism; Titrimetry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition

FEBS LETTERS, 581(7), 1425โ€“1429.

By: P. McLaughlin n, B. Bobaya, E. Regel n, R. Thompson n, J. Hoch* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: sporulation; kinases; Spo0F mutants
MeSH headings : Alanine / chemistry; Alanine / genetics; Amino Acid Sequence; Amino Acid Substitution; Bacillus subtilis / metabolism; Bacillus subtilis / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Histidine Kinase; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Interaction Mapping; Protein Kinases / chemistry; Protein Kinases / metabolism; Protein Structure, Secondary; Spores, Bacterial
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(21), 3395โ€“3408.

By: E. Soderblom n, B. Bobay n, J. Cavanagh n & M. Goshe n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Cross-Linking Reagents / chemistry; DNA-Binding Proteins / chemistry; Molecular Sequence Data; Peptide Mapping; Peptides / chemistry; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry / methods; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2006 journal article

NMR structure of AbhN and comparison with AbrBN - First insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(30), 21399โ€“21409.

By: B. Bobay n, G. Muellerโ€‰*, R. Thompson n, A. Murzin*, R. Ventersโ€‰*, M. Strauch*, J. Cavanagh n

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Bacillus subtilis / enzymology; Bacterial Proteins / metabolism; Cloning, Molecular; DNA / chemistry; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Deoxyribonuclease I / chemistry; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protein Binding; Sequence Homology, Amino Acid; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins

FEBS LETTERS, 579(25), 5669โ€“5674.

By: B. Bobay n, A. Andreeva, G. Muellerโ€‰*, J. Cavanagh n & A. Murzin

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR solution structure; protein-DNA interactions; structural genomics; structural classification of proteins
MeSH headings : Amino Acid Sequence; Bacillus subtilis / metabolism; Bacterial Proteins; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / classification; Dimerization; Escherichia coli Proteins / chemistry; Molecular Sequence Data; Protein Structure, Tertiary; Transcription Factors / chemistry; Transcription Factors / classification
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Evaluation of the DNA Binding Tendencies of the Transition State Regulator AbrBโ€ 

Biochemistry, 43(51), 16106โ€“16118.

By: B. Bobay n, L. Benson n, S. Naylor n, B. Feeney n, A. Clark n, M. Goshe n, M. Strauch n, R. Thompson n, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Circular Dichroism; DNA / chemistry; DNA / metabolism; Kinetics; Protein Binding / physiology; Spectrometry, Mass, Electrospray Ionization; Transcription Factors / chemistry; Transcription Factors / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2002 journal article

Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry

ANALYTICAL BIOCHEMISTRY, 306(2), 222โ€“227.

By: L. Benson*, J. Vaughn*, M. Strauch*, B. Bobay n, R. Thompson n, S. Naylor*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: AbrB; transition-state regulator; macromolecular assembly; mass spectrometry
MeSH headings : Bacillus subtilis; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Chromatography, Gel; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Escherichia coli; Macromolecular Substances; Protein Binding; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Spectrometry, Mass, Electrospray Ionization; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Stoichiometries of protein - Protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry

BIOCHEMISTRY, 41(25), 7859โ€“7865.

By: J. Cavanagh n, R. Thompson n, B. Bobay n, L. Benson n & S. Naylor n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / chemistry; Bacterial Proteins / chemistry; Chromatography, Gel / instrumentation; Chromatography, Gel / methods; DNA / chemistry; DNA-Binding Proteins / chemistry; Electron Transport; Electron-Transferring Flavoproteins; Flavoproteins / chemistry; Geobacillus stearothermophilus / chemistry; Humans; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Protein Binding; Protein Conformation; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

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