Works (2)
Updated: July 5th, 2023 15:59
2003 journal article
Interleukin-1 beta does not contribute to genetic strain-based differences in iNOS expression and activity in chicken macrophages
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 27(2), 137–146.
author keywords: macrophage; lipopolysaccharide; inducible nitric oxide synthase; IL-1 beta; IL-1R(1); PCR; chicken; genetic lines
MeSH headings : Animals; Chickens; Interleukin-1 / genetics; Interleukin-1 / physiology; Lipopolysaccharides / pharmacology; Macrophages / drug effects; Macrophages / enzymology; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type II; Nitrites / metabolism; RNA, Messenger / analysis; Receptors, Interleukin-1 / analysis; Receptors, Interleukin-1 / physiology; Species Specificity
TL;DR:
Observations suggest that IL-1beta is involved in mediating LPS-induced iNOS expression and activity, and the differential response of GB1 and K-strain macrophages in terms of LPS/iNOSexpression and activity is unlikely to be modulated by IL- 1beta.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Involvement of lipopolysaccharide related receptors and nuclear factor kappa B in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 88(3-4), 149–161.
author keywords: chicken macrophage; genetic lines; iNOS; CD14; TLR4; NF kappa B
MeSH headings : Animals; Chickens / genetics; Chickens / immunology; Drosophila Proteins; Enzyme Induction / drug effects; Flow Cytometry; Gene Expression Regulation, Enzymologic / drug effects; Lipopolysaccharide Receptors / biosynthesis; Lipopolysaccharide Receptors / genetics; Lipopolysaccharide Receptors / metabolism; Lipopolysaccharides / pharmacology; Macrophages / drug effects; Macrophages / enzymology; Macrophages / metabolism; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / metabolism; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Nitric Oxide Synthase / biosynthesis; Nitric Oxide Synthase / drug effects; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type II; Nitrites / metabolism; Receptors, Cell Surface / biosynthesis; Receptors, Cell Surface / metabolism; Signal Transduction / drug effects; Toll-Like Receptor 4; Toll-Like Receptors; Transcriptional Activation
TL;DR:
A differential and perhaps more stronger LPS-mediated signaling via CD14, TLR4 and NF kappa B is responsible for the heightened iNOS gene induction in K-strain (hyper- responder) macrophages than in GB2 (hypo-responder) chickens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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