Gautam Sudhir Ghatnekar

Works (2)

Updated: July 5th, 2023 15:59

2004 article

Hypoglycemia-induced changes in cell death and cell proliferation in the organogenesis-stage embryonic mouse heart (Retracted article. See vol 76, pg 278, 2006)

Ghatnekar, G. S., Barnes, J. A., Dow, J. L., & Smoak, I. W. (2004, March). BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, Vol. 70, pp. 121–131.

By: G. Ghatnekar n, J. Barnes n, J. Dow n & I. Smoak n

author keywords: embryonic heart; hypoglycemia; apoptosis; cell proliferation; flow cytometry; caspase-3; p53; PCNA
MeSH headings : Animals; Caspase 3; Caspases / metabolism; Cell Death; Cell Division; Flow Cytometry; Heart / embryology; Hypoglycemia / metabolism; Hypoglycemia / pathology; Immunohistochemistry; Mice; Organogenesis; Proliferating Cell Nuclear Antigen / metabolism; Tumor Suppressor Protein p53 / metabolism
TL;DR: Hypoglycemia reduces embryonic viability, induces significant cell death, and reduces cell proliferation in the E9.5 mouse heart, and these processes may involve active caspase-3 and p53. (via Semantic Scholar)
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Added: August 6, 2018

2002 journal article

C-13-NMR study of hypoglycemia-induced glycolytic changes in embryonic mouse heart

TERATOLOGY, 66(5), 267–272.

By: G. Ghatnekar n, H. Gracz n & I. Smoak n

MeSH headings : Animals; Carbon Isotopes; Culture Media; Glucose / metabolism; Glycolysis / physiology; Heart / embryology; Hypoglycemia / embryology; Hypoglycemia / metabolism; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred Strains; Myocardium / metabolism; Organ Culture Techniques
TL;DR: NMR effectively measures glucose and its metabolite, lactate, in the same spectrum and thus determines metabolic flux in the isolated embryonic heart after exposure to hypoglycemia and normoglycemic media, suggesting that 13C-NMR spectroscopy can be used to study glucose metabolism in isolated embryonic hearts exposed to hyp glucosecemia. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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