Angela Marie Mexas

author keywords: FIV; HIV; Regulatory T cells; Acute infection

MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary

TL;DR: The hypothesis that early activation of Treg immunosuppressor function may limit an effective anti-FIV response is supported, contributing to the establishment of chronic infection and the immunodeficiency caused by this virus. (via Semantic Scholar)

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody

MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors

TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)

author keywords: complications of diabetes mellitus; feline; lung histopathology

MeSH headings : Animals; Bacterial Typing Techniques / veterinary; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Escherichia coli / isolation & purification; Escherichia coli / pathogenicity; Escherichia coli Infections / diagnosis; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Fatal Outcome; Hemorrhage / diagnosis; Hemorrhage / microbiology; Hemorrhage / veterinary; Lung / microbiology; Lung / pathology; Male; Pneumonia, Bacterial / diagnosis; Pneumonia, Bacterial / microbiology; Pneumonia, Bacterial / veterinary; Virulence

TL;DR: A 7-month-old sexually intact male Cocker Spaniel was admitted to the North Carolina State University Veterinary Teaching Hospital for evaluation of lethargy, panting, and excessive salivation that had become progressively severe during a 5-hour period, and death was attributed to acute, severe, necrotizing pneumonia. (via Semantic Scholar)

MeSH headings : Animals; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella / pathogenicity; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae / classification; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Bartonella henselae / pathogenicity; Blood Specimen Collection / methods; DNA, Bacterial / blood; Dog Diseases / microbiology; Dogs; Edetic Acid; Female; Male; Polymerase Chain Reaction; Sequence Analysis, DNA

TL;DR: DNA from EDTA-anticoagulated blood samples obtained from four dogs was amplified and sequenced and showed that B. elizabethae should be added to the list of Bartonella species, and may have potential zoonotic implications, particularly if dogs can serve as a previously unrecognized reservoir for B. henselae. (via Semantic Scholar)