Works (5)

Updated: July 5th, 2023 15:59

2008 journal article

CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection


By: A. Mexas n, J. Fogle n, W. Tompkins n & M. Tompkins n

author keywords: FIV; HIV; Regulatory T cells; Acute infection
MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary
TL;DR: The hypothesis that early activation of Treg immunosuppressor function may limit an effective anti-FIV response is supported, contributing to the establishment of chronic infection and the immunodeficiency caused by this virus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats


By: S. Smithberg n, J. Fogle n, A. Mexas n, S. Reckling n, S. Lankford n, M. Tompkins n, G. Dean n

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pulmonary lesions in cats with diabetes mellitus


By: A. Mexas n, R. Hess*, E. Hawkins n & L. Martin n

author keywords: complications of diabetes mellitus; feline; lung histopathology
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Isolation of necrotoxigenic Escherichia coli from a dog with hemorrhagic pneumonia

Journal of the American Veterinary Medical Association, 226(12), 2016–2019.

By: E. Breitschwerdt n, C. DebRoy, A. Mexas n, T. Brown n & A. Remick n

MeSH headings : Animals; Bacterial Typing Techniques / veterinary; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Escherichia coli / isolation & purification; Escherichia coli / pathogenicity; Escherichia coli Infections / diagnosis; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Fatal Outcome; Hemorrhage / diagnosis; Hemorrhage / microbiology; Hemorrhage / veterinary; Lung / microbiology; Lung / pathology; Male; Pneumonia, Bacterial / diagnosis; Pneumonia, Bacterial / microbiology; Pneumonia, Bacterial / veterinary; Virulence
TL;DR: A 7-month-old sexually intact male Cocker Spaniel was admitted to the North Carolina State University Veterinary Teaching Hospital for evaluation of lethargy, panting, and excessive salivation that had become progressively severe during a 5-hour period, and death was attributed to acute, severe, necrotizing pneumonia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Bartonella henselae and Bartonella elizabethae as Potential Canine Pathogens

Journal of Clinical Microbiology, 40(12), 4670–4674.

By: A. Mexas n, S. Hancock n & E. Breitschwerdt n

MeSH headings : Animals; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella / pathogenicity; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae / classification; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; Bartonella henselae / pathogenicity; Blood Specimen Collection / methods; DNA, Bacterial / blood; Dog Diseases / microbiology; Dogs; Edetic Acid; Female; Male; Polymerase Chain Reaction; Sequence Analysis, DNA
TL;DR: DNA from EDTA-anticoagulated blood samples obtained from four dogs was amplified and sequenced and showed that B. elizabethae should be added to the list of Bartonella species, and may have potential zoonotic implications, particularly if dogs can serve as a previously unrecognized reservoir for B. henselae. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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