Works (5)

Updated: July 5th, 2023 15:59

2010 journal article

In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats

Toxicological Sciences, 114(1), 133–148.

By: B. Ryan, A. Hotchkiss, K. Crofton & L. Gray

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Gestational and lactational exposure to ethinyl estradiol, but not bisphenol a, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat


By: K. Howdeshell*, J. Furr*, C. Lambright*, V. Wilson*, B. Ryan n & L. Gray*

author keywords: ethinyl estradiol; bisphenol A; male reproduction; Long Evans rat; testes; epididymal sperm
MeSH headings : Anal Canal / abnormalities; Anal Canal / drug effects; Anal Canal / pathology; Animals; Animals, Newborn; Benzhydryl Compounds; Body Weight / drug effects; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Epididymis / drug effects; Epididymis / pathology; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Lactation / drug effects; Male; Maternal Exposure; Organ Size / drug effects; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology; Rats; Rats, Long-Evans; Seminal Vesicles / drug effects; Seminal Vesicles / pathology; Sperm Count; Spermatozoa / drug effects; Spermatozoa / pathology; Testis / drug effects; Testis / pathology
TL;DR: It is demonstrated that developmental exposure to oral micromolar doses of EE can permanently disrupt the reproductive tract of the male rat. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat


By: C. Blystone n, J. Furr*, C. Lambright*, K. Howdeshell*, B. Ryan*, V. Wilson*, G. LeBlanc n, L. Gray*

author keywords: prochloraz; testosterone; antiandrogen; puberty; Hershberger; steroidgenesis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; Androgen Antagonists / toxicity; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors / toxicity; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / enzymology; Genitalia, Male / growth & development; Genitalia, Male / metabolism; Imidazoles / toxicity; Male; No-Observed-Adverse-Effect Level; Orchiectomy; Organ Size / drug effects; Progesterone / blood; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Development / drug effects; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / metabolism; Testosterone / blood; Testosterone / metabolism; Testosterone Propionate / pharmacology; Time Factors; Toxicity Tests / methods
TL;DR: The fact that hormone levels were affected at dosage eightfold below that which delayed the onset of puberty suggests that rather large reductions in serum testosterone may be required to delay puberty and consistently reduce androgen-dependent tissue weights. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice


By: B. Ryan n & J. Vandenbergh n

author keywords: endocrine disruptor; environmental estrogen; bisphenol A; ethinyl estradiol; anxiety; spatial memory; puberty; behavior; mouse
MeSH headings : Analysis of Variance; Animals; Anxiety / chemically induced; Benzhydryl Compounds; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Environmental Pollutants / pharmacology; Ethinyl Estradiol / pharmacology; Exploratory Behavior / drug effects; Female; Maze Learning / drug effects; Mice; Mice, Inbred C57BL; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Sex Characteristics; Sexual Maturation / drug effects; Space Perception / drug effects; Spatial Behavior / drug effects
TL;DR: The results indicate that non-reproductive, sexually dimorphic behavior is sensitive to endocrine disruption and suggest that both humans and wildlife are being exposed to levels of these endocrine disrupting compounds that are sufficient to disrupt the development of the nervous system and that may have permanent consequences on sexuallyDimorphic behaviors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 review

Intrauterine position effects


By: B. Ryan n & J. Vandenbergh n

author keywords: anogenital distance; behavior; endocrine disruption; human; intrauterine position; rodent; stress; testosterone; toxicology
MeSH headings : Aggression; Animals; Behavior, Animal; Embryonic and Fetal Development / physiology; Environment; Female; Gonadal Steroid Hormones / metabolism; Gonadal Steroid Hormones / pharmacology; Gonadal Steroid Hormones / physiology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Sex Characteristics; Sex Differentiation / physiology; Sex Factors; Sex Ratio; Sexual Behavior; Stress, Physiological; Territoriality; Twin Studies as Topic; Uterus / embryology; Uterus / enzymology; Uterus / physiology
TL;DR: IUP effects may impact a number of scientific fields of research such as endocrine disruption, toxicology, population biology, animal production and health, and some of these effects are similar to the influence of prenatal stress on adult phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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