@article{bidgood_papich_2005, title={Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs}, volume={28}, ISSN={["1365-2885"]}, DOI={10.1111/j.1365-2885.2005.00664.x}, abstractNote={Enrofloxacin and marbofloxacin were administered to six healthy dogs in separate crossover experiments as a single oral dose (5 mg/kg) and as a constant rate IV infusion (1.24 and 0.12 mg/h·kg, respectively) following a loading dose (4.47 and 2 mg/kg, respectively) to achieve a steady‐state concentration of approximately 1 μg/mL for 8 h. Interstitial fluid (ISF) was collected with anin vivoultrafiltration device at the same time period as plasma to measure protein unbound drug concentrations at the tissue site and assess the dynamics of drug distribution. Plasma and ISF were analyzed for enrofloxacin, its active metabolite ciprofloxacin, and for marbofloxacin by high performance liquid chromatography (HPLC). Lipophilicity and protein binding of enrofloxacin were higher than for marbofloxacin and ciprofloxacin. Compared to enrofloxacin, marbofloxacin had a longer half‐life, higherCmax, and largerAUC0−∞in plasma and ISF after oral administration. Establishing steady state allowed an assessment of the dynamics of drug concentrations between plasma and ISF. The ISF and plasma‐unbound concentrations were similar during the steady‐state period despite differences in lipophilicity and pharmacokinetic parameters of the drugs.}, number={4}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Bidgood, TL and Papich, MG}, year={2005}, month={Aug}, pages={329–341} }
 @article{bidgood_papich_2003, title={Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs}, volume={64}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.2003.64.1040}, abstractNote={Abstract}, number={8}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Bidgood, TL and Papich, MG}, year={2003}, month={Aug}, pages={1040–1046} }
 @article{bidgood_papich_2002, title={Plasma pharmacokinetics and tissue fluid concentrations of meropenem after intravenous and subcutaneous administration in dogs}, volume={63}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.2002.63.1622}, abstractNote={Abstract}, number={12}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Bidgood, T and Papich, MG}, year={2002}, month={Dec}, pages={1622–1628} }