Decreased survival of C/EBPβ-deficient keratinocytes is due to aberrant regulation of p53 levels and function
Yoon, K., Zhu, S., Ewing, S. J., & Smart, R. C. (2006, July 10). Oncogene, Vol. 26, pp. 360–367.
author keywords: apoptosis; p53; C/EBP beta; keratinocytes
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Cell Survival; Epidermis / drug effects; Epidermis / metabolism; Epidermis / pathology; Female; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; In Situ Nick-End Labeling; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2 / metabolism; Proto-Oncogene Proteins c-mdm2 / metabolism; Proto-Oncogene Proteins p21(ras) / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Ubiquitin and proteasome pathways; Cell death mechanisms and regulation
TL;DR:
The results demonstrate that altered keratinocyte survival in C/EBPβ−/− mice results from aberrant regulation of p53 protein and function and indicate C/ EBPβ has a role in the negative regulation ofp53 protein levels in response to carcinogen-induced stress.
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2. Zero Hunger
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