Works (8)
Updated: July 16th, 2023 21:15
2018 journal article
Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes
NANOTOXICOLOGY, 12(9), 975–991.
author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
TL;DR:
Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 4, 2019
2010 journal article
Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 43(2), 142–151.
author keywords: carbon nanotubes; inflammation; lipopolysaccharide; fibrosis; growth factors
MeSH headings : Animals; Bacteria / metabolism; Fibroblasts / metabolism; Fibrosis; Inflammation; Lipopolysaccharides / metabolism; Macrophages / metabolism; Male; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Platelet-Derived Growth Factor / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; Soot / chemistry
TL;DR:
The data suggest that LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasingPDGF-Ralpha on pulmonary fibroblasts.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium pentoxide
RESPIRATORY RESEARCH, 11.
MeSH headings : Animals; Cytokines / metabolism; Male; Mice; Mice, Inbred AKR; Pneumonia / chemically induced; Pneumonia / complications; Pneumonia / metabolism; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / complications; Pulmonary Fibrosis / metabolism; Respiratory Syncytial Virus Infections / complications; Respiratory Syncytial Virus Infections / metabolism; Vanadium Compounds
TL;DR:
It is suggested that RSV infection reduces the severity of V2O5-induced fibrosis by suppressing growth factors and collagen genes and suggests that viral infection also suppresses the innate immune response that normally serves to resolve V2 O5- induced fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(3), 349–358.
author keywords: carbon nanotubes; asthma; fibrosis; lung
MeSH headings : Administration, Inhalation; Aerosols; Animals; Asthma / chemically induced; Asthma / immunology; Asthma / pathology; Bronchoalveolar Lavage Fluid / cytology; Fibrosis / chemically induced; Fibrosis / immunology; Fibrosis / pathology; Humans; Interleukin-13 / immunology; Lung / cytology; Lung / immunology; Lung / pathology; Macrophages / cytology; Macrophages / metabolism; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Ovalbumin / immunology; Particle Size; Platelet-Derived Growth Factor / immunology; Random Allocation; Transforming Growth Factor beta1 / immunology
TL;DR:
It is indicated that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled multiwalled carbon nanotubes, and combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airways fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhaled carbon nanotubes reach the subpleural tissue in mice
NATURE NANOTECHNOLOGY, 4(11), 747–751.
MeSH headings : Aerosols / adverse effects; Animals; Immunity / drug effects; Inhalation Exposure / analysis; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Pleura / drug effects; Pleura / immunology; Pleura / ultrastructure; Pulmonary Fibrosis / chemically induced
TL;DR:
It is shown that multi-walled carbon nanotubes reach the sub-pleura in mice after a single inhalation exposure of 30 mg/m3 for 6 hours and it is suggested that minimizing inhalation of nanot tubes during handling is prudent until further long term assessments are conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Pathology of end-stage remodeling in a family of cats with hypertrophic cardiomyopathy
VETERINARY PATHOLOGY, 42(4), 458–467.
author keywords: burned-out phase; dilated phase; end stage; feline; hypertrophic cardiomyopathy; myocardial fibrosis
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / pathology; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / pathology; Cats; Fatal Outcome; Female; Histological Techniques / veterinary; In Situ Nick-End Labeling / veterinary; Male; Myocardium / pathology; Ventricular Remodeling / physiology
TL;DR:
The objectives were to describe the pathologic alterations associated with ES-HCM and investigate the pathogenesis in three of the four cats, and to exclude apoptosis or coronary vessel spasm on the basis of the data presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs
JOURNAL OF INHERITED METABOLIC DISEASE, 26(5), 489–504.
MeSH headings : Acetylglucosaminidase / deficiency; Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Glycosaminoglycans / urine; Male; Mucopolysaccharidosis III / genetics; Mucopolysaccharidosis III / metabolism; Mucopolysaccharidosis III / pathology
TL;DR:
Dogs with naturally occurring MPS IIIB are reported on, detailing the clinical signs, diagnosis, histopathology, tissue enzymology and substrate levels, and an obligate heterozygote has been established to aid in understanding the pathogenesis of MPSIIIB and testing of potential therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Modulation of fibroblast growth factor expression and signal transduction in type II cells
Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429S–429S.
MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
TL;DR:
The data suggests that airway fibroblasts from severe asthmatics may be of a synthetic phenotype, with altered capabilities in collagen production, as compared to those from patients with mild-to-moderate asthma and normal control subjects, and this may be driven by an increased expression of PDGFR.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
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