@article{uhl_krimer_schliekelman_tompkins_suter_2011, title={Identification of Altered MicroRNA Expression in Canine Lymphoid Cell Lines and Cases of B- and T-Cell Lymphomas}, volume={50}, ISSN={["1098-2264"]}, DOI={10.1002/gcc.20917}, abstractNote={AbstractCanine lymphoma is a common spontaneous tumor with many similarities to human lymphoma, and thus has potential to be an important animal model of lymphomagenesis. This study determined that microRNA (miRNA) expression in canine tumors can be assessed using a commercially available human cancer miRNA qPCR array. miRNA expression in six different canine lymphoid cell lines and in naturally occurring canine B‐ and T‐cell lymphomas was compared using RNA harvested from normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN) as controls. We found that false discovery rate (FDR) correction for multiple testing after quantile normalization controlled for variation across arrays and that they were the best methods for normalization and statistical analysis. Increases in miRNAs known to upregulate oncogenes (miR19a+b, miR17‐5p) and decreased expression of miRNAs with tumor suppressor functions (miR‐203, miR‐218, and miR‐181a) also seen in human lymphoid malignancies were observed. However, there were few similarities between canine groups. The results of this study indicate that the use of both PBMC and LN cells as controls provides different, but potentially equally important targets for further analysis. Our findings of miRNA dysregulation in canine lymphoid cell lines and clinical cases of lymphoma emphasize the potential of canine lymphoma as an important spontaneous, large animal model of human B‐ and T‐cell lymphomas. © 2011 Wiley‐Liss, Inc.}, number={11}, journal={GENES CHROMOSOMES & CANCER}, author={Uhl, Elizabeth and Krimer, Paula and Schliekelman, Paul and Tompkins, S. Mark and Suter, Steven}, year={2011}, month={Nov}, pages={950–967} }
 @article{schliekelman_2003, title={Transient dynamics in multilocus invasions by transgenic organisms}, volume={46}, ISSN={["0303-6812"]}, DOI={10.1007/s00285-002-0176-4}, abstractNote={With recent advances in molecular genetics, it is likely that releases of genetically modified organisms will be used for a variety of purposes. In many cases, such systems would utilize organisms that have been modified on multiple genetic loci. Predicting the effect of such releases will require an understanding of the transient dynamics in the system. However, theoretical understanding of transient dynamics in multilocus systems is limited, particularly for early generations when gametic disequilibrium is still high. I derive approximate expressions for marginal allele frequency and marginal two-locus disequilibrium that are applicable in this initial period, assuming infinite population size, two alleles per locus, and weak viability selection. I then apply these results to exploring the effect of parameters on the frequency of the resident gamete type in a release of organisms carrying an autocidal allele on multiple loci. This leads to simple approximate expressions for the optimal number of loci carrying the autocidal allele (as a function of release size and the degree of natural selection against the alleles) and the size of release needed to overcome a given level of selection against the released alleles.}, number={2}, journal={JOURNAL OF MATHEMATICAL BIOLOGY}, author={Schliekelman, P}, year={2003}, month={Feb}, pages={171–188} }
 @article{gould_schliekelman_2000, title={Reassessing autocidal pest control}, ISBN={0890542465}, journal={Emerging technologies for integrated pest management : concepts, research, and implementation}, publisher={St. Paul, MN : APS Press,}, author={Gould, F. and Schliekelman, P.}, year={2000}, pages={190} }