@article{gieger_rassnick_siegel_proulx_bergman_anderson_ladue_smith_northrup_roberts_2008, title={Palliation of clinical signs in 48 dogs with nasal carcinomas treated with coarse-fraction radiation therapy}, volume={44}, ISSN={["1547-3317"]}, DOI={10.5326/0440116}, abstractNote={Data from 48 dogs with nasal carcinomas treated with palliative radiation therapy (PRT) were retrospectively reviewed. Factors potentially influencing resolution of clinical signs and survival after PRT were evaluated. Clinical signs completely resolved in 66% of dogs for a median of 120 days. The overall median survival time was 146 days. Duration of response to PRT was shorter in dogs that had clinical signs for <90 days before PRT. Survival times were shorter in dogs that had partial or no resolution of clinical signs after PRT than in dogs that had complete resolution of clinical signs.}, number={3}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Gieger, Tracy and Rassnick, Kenneth and Siegel, Sheri and Proulx, David and Bergman, Philip and Anderson, Christine and LaDue, Tracy and Smith, Annette and Northrup, Nicole and Roberts, Royce}, year={2008}, pages={116–123} } @article{looper_malarkey_ruslander_proulx_thrall_2006, title={Epidermal growth factor receptor expression in feline oral squamous cell carcinomas}, volume={4}, ISSN={["1476-5829"]}, DOI={10.1111/j.1476-5810.2006.00091.x}, abstractNote={AbstractFeline oral squamous cell carcinomas (SCC) have a poor prognosis despite aggressive treatment with surgery, radiation and anticancer drugs. Overexpression of the epidermal growth factor receptor (EGFR), a membrane‐bound tyrosine kinase receptor, has been found in many human epithelial neoplasms, including oral SCC. EGFR overexpression has been associated with advanced disease and a poor prognosis. The purpose of this study was to determine whether feline oral SCC express EGFR. Thirteen formalin‐fixed paraffin wax‐embedded biopsy samples from feline oral SCC were analysed for EGFR expression using immunohistochemistry. Nine of 13 tumours (69%) were positive for EGFR expression, suggesting that altered EGFR expression plays a role in feline oral SCC and provides a rationale for a potential clinical benefit using EGFR inhibitors in combination with conventional treatments.}, number={1}, journal={VETERINARY AND COMPARATIVE ONCOLOGY}, author={Looper, J. S. and Malarkey, D. E. and Ruslander, D. and Proulx, D. and Thrall, D. E.}, year={2006}, month={Mar}, pages={33–40} } @article{rassnick_goldkamp_erb_scrivani_njaa_gieger_turek_mcniel_proulx_chun_et al._2006, title={Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 cases (1993-2003)}, volume={229}, ISSN={["0003-1488"]}, DOI={10.2460/javma.229.3.401}, abstractNote={Abstract Objective—To evaluate factors associated with survival in dogs with nasal carcinomas that did not receive treatment or received only palliative treatment. Design—Retrospective case series. Animals—139 dogs with histologically confirmed nasal carcinomas. Procedures—Medical records, computed tomography images, and biopsy specimens of nasal carcinomas were reviewed. Only dogs that were not treated with radiation, surgery, chemotherapy, or immunotherapy and that survived ≥ 7 days from the date of diagnosis were included. The Kaplan-Meier method was used to estimate survival time. Factors potentially associated with survival were compared by use of log-rank and Wilcoxon rank sum tests. Multivariable survival analysis was performed by use of the Cox proportional hazards regression model. Results—Overall median survival time was 95 days (95% confidence interval [CI], 73 to 113 days; range, 7 to 1,114 days). In dogs with epistaxis, the hazard of dying was 2.3 times that of dogs that did not have epistaxis. Median survival time of 107 dogs with epistaxis was 88 days (95% CI, 65 to 106 days) and that of 32 dogs without epistaxis was 224 days (95% CI, 54 to 467 days). Conclusions and Clinical Relevance—The prognosis of dogs with untreated nasal carcinomas is poor. Treatment strategies to improve outcome should be pursued.}, number={3}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Rassnick, Kenneth M. and Goldkamp, Carrie E. and Erb, Hollis N. and Scrivani, Peter V. and Njaa, Bradley L. and Gieger, Tracy L. and Turek, Michelle M. and McNiel, Elizabeth A. and Proulx, David R. and Chun, Ruthanne and et al.}, year={2006}, month={Aug}, pages={401–406} } @article{hawkins_grooters_cowgill_proulx_davainis_ruslander_grindem_2006, title={Treatment of Conidiobolus sp pneumonia with itraconazole in a dog receiving immunosuppressive therapy}, volume={20}, DOI={10.1111/j.1939-1676.2006.tb00769.x}, abstractNote={Journal of Veterinary Internal MedicineVolume 20, Issue 6 p. 1479-1482 Open Access Treatment of Conidiobolus sp. Pneumonia with Itraconazole in a Dog Receiving Immunosuppressive Therapy Eleanor C. Hawkins DVM, DACVIM (SAIM), Eleanor C. Hawkins DVM, DACVIM (SAIM) Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606; e-mail: eleanor_hawkins@ncsu.edu.Search for more papers by this authorAmy M. Grooters, Amy M. Grooters Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.Search for more papers by this authorElizabeth S. Cowgill, Elizabeth S. Cowgill Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorDavid R. Proulx, David R. Proulx Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorGrace M. Davainis, Grace M. Davainis Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorDavid M. Ruslander, David M. Ruslander Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this author Eleanor C. Hawkins DVM, DACVIM (SAIM), Eleanor C. Hawkins DVM, DACVIM (SAIM) Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606; e-mail: eleanor_hawkins@ncsu.edu.Search for more papers by this authorAmy M. Grooters, Amy M. Grooters Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.Search for more papers by this authorElizabeth S. Cowgill, Elizabeth S. Cowgill Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorDavid R. Proulx, David R. Proulx Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorGrace M. Davainis, Grace M. Davainis Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorDavid M. Ruslander, David M. Ruslander Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this author First published: 05 February 2008 https://doi.org/10.1111/j.1939-1676.2006.tb00769.xCitations: 11 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000; 13: 236– 301. 2 Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: A review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 2004; 10: 31– 47. 3 Grooters AM. Pythiosis, lagenidiosis, and zygomycosis in small animals. Vet Clin North Am Small Anim Pract 2003; 33: 695– 720. 4 Humber RA, Brown CC, Kornegay RW. Equine zygomycosis caused by Conidiobolus lamprauges. J Clin Microbiol 1989; 27: 573– 576. 5 Temple ME, Brady MT, Koranyi KI, et al. Periorbital cellulitis secondary to Conidiobolus incongruus. Pharmacotherapy 2001; 21: 351– 354. 6 Sharma NL, Mahajan VK, Singh P. Orofacial conidiobolo-mycosis due to Conidiobolus incongruus. Mycoses 2003; 46: 137– 140. 7 Khan ZU, Khoursheed M., Makar R., et al. Basidiobolus ranarum as an etiologic agent of gastrointestinal zygomycosis. J Clin Microbiol 2001; 39: 2360– 2363. 8 Zamos DT, Schumacher J., Loy JK. Nasopharyngeal conidiobolomycosis in a horse. J Am Vet Med Assoc 1996; 208: 100– 101. 9 Ketterer PJ, Kelly MA, Connole MD, et al. Rhinocerebral and nasal zygomycosis in sheep caused by Conidiobolus incongruus. Aust Vet J 1992; 69: 85– 87. 10 Morris M., Ngeleka M., Adogwa AO, et al. Rhinocerebral zygomycosis in a sheep. Can Vet J 2001; 42: 227– 228. 11 Carrigan MJ, Small AC, Perry GH. Ovine nasal zygomycosis caused by Conidiobolus incongruus. Aust Vet J 1992; 69: 23– 240. 12 Bauer RW, LeMarie SL, Roy AF. Oral conidiobolomycosis in a dog. Vet Dermatol 1997; 8: 115– 120. 13 Hillier A., Kunkle GA, Ginn PE, et al. Canine subcutaneous zygomycosis caused by Conidiobolus sp: A case report and review of Conidiobolus infections in other species. Vet Dermatol 1994; 5: 205– 213. 14 French RA, Ashworth CD. Zygomycosis caused by Conidiobolus coronatus in a llama (Lama glama). Vet Pathol 1994; 31: 120– 122. 15 Moll HD, Schumacher J., Hoover TR. Entomophthoramycosis conidiobolae in a llama. J Am Vet Med Assoc 1992; 200: 969– 970. 16 Stephens CP, Gibson JA. Disseminated zygomycosis caused by Conidiobolus incongruus in a deer. Aust Vet J 1997; 75: 358– 359. 17 Steiger RR, Williams MA. Granulomatous tracheitis caused by Conidiobolus coronatus in a horse. J Vet Intern Med 2000; 14: 311– 314. 18 King JC, Dunphy D. Fatal phycomycosis without underlying disease. J Iowa Med Soc 1972; 62: 485– 488. 19 King DS, Jong SC. Identity of the etiological agent of the first deep entomophthoraceous infection of man in the United States. Mycologia 1976; 68: 181– 183. 20 Eckert HL, Khoury GH, Pore RS, et al. Entomophthora phycomycotic infection reported for the first time in the United States. Chest 1972; 61: 392– 394. 21 Busapakum R., Youngchaiyud U., Sriumpai S., et al. Disseminated infection with Conidiobolus incongruus. Sabouraudia 1983; 21: 323– 330. 22 Jaffey PB, Haque AK, El-Zaatari M., et al. Disseminated Conidiobolus infection with endocarditis in a cocaine abuser. Arch Pathol Lab Med 1990; 114: 1276– 1278. 23 Walker SD, Clark RV, King CT, et al. Fatal disseminated Conidiobolus coronatus infection in a renal transplant patient. Am J Clin Pathol 1992; 98: 559– 564. 24 Affolter VK, Moore PF. Canine cutaneous and systemic histiocytosis: Reactive histiocytosis of dermal dendritic cells. Am J Dermatopathol 2000; 21: 40– 48. 25 Espinel-Ingroff A. Utility of mould susceptibility testing. Curr Opin Infect Dis 2003; 16: 527– 532. Citing Literature Volume20, Issue6November 2006Pages 1479-1482 ReferencesRelatedInformation}, number={6}, journal={Journal of Veterinary Internal Medicine}, author={Hawkins, Eleanor and Grooters, A. M. and Cowgill, E. S. and Proulx, D. R. and Davainis, G. M. and Ruslander, D. M. and Grindem, C. B.}, year={2006}, pages={1479–1482} } @article{proulx_ruslander_dodge_hauck_williams_horn_price_thrall_2003, title={A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation}, volume={44}, ISSN={["1058-8183"]}, DOI={10.1111/j.1740-8261.2003.tb00468.x}, abstractNote={Despite the early notion that canine oral malignant melanoma is radioresistant, recent data suggest that external beam radiotherapy is effective in local tumor control. However, optimal fractionation schedules have not been established. The high rate of regional and distant metastasis is another problem that has hindered long‐term control. The role of chemotherapy in the management of canine oral melanoma has also not been determined. In this study, data from 140 dogs irradiated at North Carolina State University were evaluated with the following objectives: (1) to compare the efficacy of three radiation therapy protocols (36 Gy, 9 Gy × 4 fractions; 30 Gy, 10 Gy × 3 fractions; or >45 Gy, 2–4 Gy × 12–19 fractions) for the treatment of dogs with oral malignant melanoma, (2) to identify any host or tumor factors influencing prognosis, and (3) to determine the impact of systemic chemotherapy on treatment outcome. Information regarding response to therapy, disease progression, and survival were determined from the medical records or from information obtained by telephone or mail survey. Relationships between host, tumor, and treatment variables and outcome measures (response, time to first event, and survival) were evaluated using Fisher's exact test (response) and the Cox regression model (time to first event and survival). The median time to first event for the 140 dogs was 5.0 months (95% C.I., 4–6 months) and the median survival was 7.0 months (95% C.I., 6–9 months). In the univariate analysis, the following variables were associated with increased time to first event and survival: (1) rostral tumor sublocation; (2) lack of bone lysis observed on skull imaging, and (3) microscopic tumor burden. In a multivariate analysis of 111 dogs with complete data for these variables, tumor sublocation, bone lysis, and tumor volume were identified as joint predictors of time to first event (p<.001,p<.001, andp= .04, respectively) and survival (p<.001,p<.001, andp= 05, respectively). There were no differences in response, time to first event and survival between the three radiation therapy protocols used. Systemic chemotherapy had no impact on the development of metastatic disease, time to first event, or survival, although the dosages used in this study were suboptimal. External beam radiation therapy is effective in local disease control of canine oral malignant melanoma; however, the optimal fractionation scheme has yet to be determined. The high metastatic rate observed with this disease and the inefficacy of systemic chemotherapy indicate that further investigation into novel therapies is warranted.}, number={3}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Proulx, DR and Ruslander, DM and Dodge, RK and Hauck, ML and Williams, LE and Horn, B and Price, GS and Thrall, DE}, year={2003}, pages={352–359} } @article{hahn_proulx_muruthi_alberts_altmann_2003, title={Gastrointestinal parasites in free-ranging Kenyan baboons (Papio cynocephalus and P-anubis)}, volume={24}, ISSN={["0164-0291"]}, DOI={10.1023/A:1023092915171}, number={2}, journal={INTERNATIONAL JOURNAL OF PRIMATOLOGY}, author={Hahn, NE and Proulx, D and Muruthi, PM and Alberts, S and Altmann, J}, year={2003}, month={Apr}, pages={271–279} } @article{michau_proulx_rushton_olivry_dunston_gilger_davidson_2003, title={Intraocular extramedullary plasmacytoma in a cat}, volume={6}, ISSN={["1463-5224"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-0037629973&partnerID=MN8TOARS}, DOI={10.1046/j.1463-5224.2003.00277.x}, abstractNote={AbstractAn 8‐year‐old, castrated male Domestic Short‐haired cat was referred for evaluation of a possible intraocular neoplasm following previous ocular trauma. The eye was blind, and uveitis and an iridal mass were noted on examination. An enucleation was performed and the mandibular lymph node excised. Histopathologic examination revealed neoplastic proliferation of plasma cells in the iris and lymph node. No other evidence of disseminated disease was detected. This is the first case reported of an intraocular extramedullary plasmacytoma in the cat. The variation in clinical manifestations and potential association with multiple myeloma are not known at this time. Disseminated metastasis from a primary plasmacytoma of the uveal tract could also involve the bone marrow and be indistinguishable from multiple myeloma. Early enucleation, as in trauma‐associated sarcomas, may be indicated to prevent metastasis. Periodic systemic evaluation for evidence of multiple myeloma should be performed.}, number={2}, journal={VETERINARY OPHTHALMOLOGY}, author={Michau, TM and Proulx, DR and Rushton, SD and Olivry, T and Dunston, SM and Gilger, BC and Davidson, MG}, year={2003}, month={Jun}, pages={177–181} }