Huan Xie

Works (3)

Updated: July 5th, 2023 15:58

2004 journal article

Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains

BIOCONJUGATE CHEMISTRY, 15(3), 482–490.

By: A. Tkachenko, H. Xie n, Y. Liu n, D. Coleman n, J. Ryan n, W. Glomm n, M. Shipton n, S. Franzen n , D. Feldheim n

MeSH headings : 3T3 Cells; Animals; Biological Transport, Active / physiology; Cell Line, Tumor; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Gene Products, tat / chemistry; Gold / chemistry; Gold / pharmacokinetics; HeLa Cells; Humans; Macromolecular Substances; Mice; Nuclear Localization Signals / drug effects; Nuclear Localization Signals / metabolism; Peptides / chemistry; Peptides / pharmacokinetics; Protein Structure, Tertiary / physiology; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Temperature; Transduction, Genetic
TL;DR: Video-enhanced color differential interference contrast microscopy and transmission electron microscopy indicated that transport of nanoparticles into the cytoplasm and nucleus depends on peptide sequence and cell line, and cellular uptake of Tat PTD peptide-gold nanoparticle conjugates was temperature dependent, suggesting an endosomal pathway of uptake. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Preparation of protein gradients through the controlled deposition of protein-nanoparticle conjugates onto functionalized surfaces

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(17), 5388–5395.

By: S. Kramer n, H. Xie n, J. Gaff n, . Williamson n, A. Tkachenko, N. Nouri n, D. Feldheim n, D. Feldheim n

MeSH headings : Animals; Axons / drug effects; Axons / physiology; Cattle; Cell Division / drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; Gold Colloid / chemistry; Gold Colloid / pharmacology; Hippocampus / cytology; Metals / chemistry; Microscopy, Fluorescence; Nanotechnology; Neurons / cytology; Neurons / drug effects; Polylysine / chemistry; Rats; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacology; Spectrophotometry
TL;DR: Surfaces patterned with proteins using the procedures described within are shown to support cell growth and are thus suitable for studies of protein-cell interactions. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Critical flocculation concentrations, binding isotherms, and ligand exchange properties of peptide-modified gold nanoparticles studied by UV-visible, fluorescence, and time-correlated single photon counting spectroscopies

ANALYTICAL CHEMISTRY, 75(21), 5797–5805.

By: H. Xie n, A. Tkachenko, W. Glomm n, J. Ryan n, M. Brennaman  n, J. Papanikolas  n, S. Franzen  n, D. Feldheim n

MeSH headings : 2,2'-Dipyridyl / analogs & derivatives; 2,2'-Dipyridyl / chemistry; Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Coordination Complexes; Dithionitrobenzoic Acid / chemistry; Flocculation; Fluorescamine / chemistry; Glutathione / chemistry; Gold Colloid / chemistry; Gold Colloid / metabolism; Kinetics; Ligands; Nanotechnology / methods; Particle Size; Peptides / chemistry; Protein Binding; Rhodamines / chemistry; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides / chemistry; Sulfhydryl Compounds / chemistry
TL;DR: Protocols for modifying gold nanoparticles with peptide-bovine serum albumin (BSA) conjugates are described within and TCSPC has proven to be a powerful technique for observing the microenvironment of protein-gold nanoparticle conjugacy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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