Ian Dworkin

Works (13)

Updated: July 5th, 2023 15:58

2011 journal article

The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster

GENETICS, 187(4), 1171–U314.

By: I. Dworkin n, J. Anderson  n, Y. Idaghdour n, E. Parker n, E. Stone n & G. Gibson n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genetic Variation; Genome, Insect; Genotype; Heterozygote; Linear Models; Multigene Family; Mutation; Phenotype; Transcriptional Activation; Wings, Animal / growth & development
TL;DR: Weak mutational perturbations in genes affecting wing development in Drosophila melanogaster that influence wing shape relative to a co-isogenic wild type are used to examine overall patterns of covariation between phenotypic variables of interest and underlying aspects of gene activity. (via Semantic Scholar)
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13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster

GENETICS, 181(3), 1065–1076.

By: I. Dworkin n, E. Kennerly n, D. Tack *, J. Hutchinson n, J. Brown n, J. Mahaffey n, G. Gibson n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / cytology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Gene Expression Regulation; Genetic Linkage; Genetic Variation; Genome, Insect / genetics; Genomics; Molecular Sequence Data; Mutation; Nuclear Proteins / genetics; Oligonucleotide Array Sequence Analysis; Transcription Factors / genetics; Transcription, Genetic; Wings, Animal / metabolism
TL;DR: This study demonstrates that phenotypic expressivity of the scallopedE3 (sdE3) mutation of Drosophila melanogaster is background dependent and is the result of at least one major modifier segregating between two standard lab wild-type strains and demonstrates that the epistatic interaction between sdE3 and an optomotor blind mutation is backgrounddependent. (via Semantic Scholar)
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13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Genetics of microenvironmental canalization in Arabidopsis thaliana

Proceedings of the National Academy of Sciences of the United States of America, 104(34), 13717–13722.

By: M. Hall, I. Dworkin, M. Ungerer & M. Purugganan

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

GENETICS, 173(3), 1417–1431.

By: I. Dworkin n & G. Gibson n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; ErbB Receptors / genetics; ErbB Receptors / metabolism; Genetic Variation; Genotype; Morphogenesis; Mutation; Signal Transduction / genetics; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Wings, Animal / anatomy & histology
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UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 review

Insulin signaling and limb-patterning: candidate pathways for the origin and evolutionary diversification of beetle 'horns'

[Review of ]. Heredity, 97(3), 179–191.

By: D. Emlen, Q. Szafran, L. Corley & I. Dworkin

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

A study of canalization and developmental stability in the sternopleural bristle system of Drosophila melanogaster

Evolution, 59(7), 1500–1509.

By: I. Dworkin

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Evidence for canalization of Distal-less function in the leg of Drosophila melanogaster

EVOLUTION & DEVELOPMENT, Vol. 7, pp. 89–100.

By: I. Dworkin n

MeSH headings : Animals; Drosophila melanogaster; Evolution, Molecular; Extremities / anatomy & histology; Extremities / physiology; Female; Genetic Variation; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Male; Models, Genetic; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: There is no evidence to support the hypothesis of the evolution of genetic canalization as a response to microenvironmental canalization, and although there are genetic correlations between these traits, there is no association between their measures of canalization. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Replication of an egfr-wing shape association in a wild-caught cohort of Drosaphila melanogaster

GENETICS, 169(4), 2115–2125.

By: I. Dworkin n, A. Palsson  n & G. Gibson n

MeSH headings : Alleles; Analysis of Variance; Animals; Chromosome Mapping; Cohort Studies; Drosophila melanogaster / metabolism; ErbB Receptors / metabolism; ErbB Receptors / physiology; Evolution, Molecular; Gene Frequency; Genotype; Linkage Disequilibrium; Models, Genetic; Phenotype; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Wings, Animal / anatomy & histology; Wings, Animal / embryology
TL;DR: It is demonstrated that despite considerable phenotypic differences for wing shape between a lab-reared experimental population and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing shape can be replicated. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology

BMC Genetics, 6.

By: A. Palsson, J. Dodgson, I. Dworkin & G. Gibson

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Towards a genetic architecture of cryptic genetic variation and genetic assimilation: The contribution of K.G. Bateman

Dworkin, I. (2005, December). JOURNAL OF GENETICS, Vol. 84, pp. 223–226.

By: I. Dworkin n

author keywords: genetic assimilation; selection; phenocopy; phenotype
MeSH headings : Alleles; Animals; Biological Evolution; Drosophila melanogaster / genetics; Gene Frequency; Genetic Variation; History, 20th Century; Models, Genetic; Polymorphism, Genetic
TL;DR: This commentary will discuss the context of this work examining the genetic architecture of the crossveinless phenocopy both within the light of current studies of evolutionary genetics, and modern evolutionary-developmental biology. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Nucleotide variation in the Egfr locus of Drosophila melanogaster

GENETICS, 167(3), 1199–1212.

By: A. Palsson n, A. Rouse n, R. Riley-Berger n, I. Dworkin n & G. Gibson n

MeSH headings : Analysis of Variance; Animals; Base Sequence; California; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; ErbB Receptors / genetics; Gene Frequency; Genetic Variation; Genetics, Population; Haplotypes / genetics; Kenya; Linkage Disequilibrium; Molecular Sequence Data; North Carolina; Polymorphism, Genetic; Protein Kinases / genetics; Receptors, Invertebrate Peptide / genetics; Sequence Analysis, DNA
TL;DR: Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6.4 kb of potential regulatory regions in a sample of 250 alleles from three populations of Drosophila melanogaster suggests that the intensity of different population genetic forces varies along the locus. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 review

Uncovering cryptic genetic variation

[Review of ]. NATURE REVIEWS GENETICS, 5(9), 681–U11.

By: G. Gibson n & I. Dworkin n

MeSH headings : Animals; Drosophila melanogaster / genetics; Genetic Variation; Linkage Disequilibrium; Quantitative Trait, Heritable; Selection, Genetic
TL;DR: It is argued that cryptic genetic variation is pervasive but under-appreciated, recent progress in determining the nature and identity of genes that underlie cryptic genetic effects is highlighted, and future research directions are outlined. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster

CURRENT BIOLOGY, 13(21), 1888–1893.

By: I. Dworkin n, A. Palsson n, K. Birdsall n & G. Gibson n

MeSH headings : Alleles; Animals; California; Crosses, Genetic; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Epistasis, Genetic; Female; Genes, erbB-1 / genetics; Genetic Variation; Inbreeding; Linkage Disequilibrium; Male; Photoreceptor Cells, Invertebrate / anatomy & histology; Polymorphism, Single Nucleotide; Selection, Genetic; Sequence Analysis, DNA
TL;DR: Replication of the strongest associations with an independent sample of 302 phenotypically extreme individuals derived from 1000 crosses of Egfr(E1) to freshly trapped males and a tendency for the rarer alleles to have more disrupted eye development suggests that mutation-selection balance is a possible mechanism contributing to maintaining cryptic variation for Egfr. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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