@article{dworkin_anderson_idaghdour_parker_stone_gibson_2011, title={The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster}, volume={187}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.110.125922}, abstractNote={Abstract}, number={4}, journal={GENETICS}, author={Dworkin, Ian and Anderson, Julie A. and Idaghdour, Youssef and Parker, Erin Kennerly and Stone, Eric A. and Gibson, Greg}, year={2011}, month={Apr}, pages={1171–U314} }
 @article{dworkin_kennerly_tack_hutchinson_brown_mahaffey_gibson_2009, title={Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster}, volume={181}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.108.096453}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Dworkin, Ian and Kennerly, Erin and Tack, David and Hutchinson, Jennifer and Brown, Julie and Mahaffey, James and Gibson, Greg}, year={2009}, month={Mar}, pages={1065–1076} }
 @article{hall_dworkin_ungerer_purugganan_2007, title={Genetics of microenvironmental canalization in Arabidopsis thaliana}, volume={104}, number={34}, journal={Proceedings of the National Academy of Sciences of the United States of America}, author={Hall, M. C. and Dworkin, I. and Ungerer, M. C. and Purugganan, M.}, year={2007}, pages={13717–13722} }
 @article{dworkin_gibson_2006, title={Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster}, volume={173}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.105.053868}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Dworkin, Ian and Gibson, Greg}, year={2006}, month={Jul}, pages={1417–1431} }
 @misc{emlen_szafran_corley_dworkin_2006, title={Insulin signaling and limb-patterning: candidate pathways for the origin and evolutionary diversification of beetle 'horns'}, volume={97}, number={3}, journal={Heredity}, author={Emlen, D. J. and Szafran, Q. and Corley, L. S. and Dworkin, I.}, year={2006}, pages={179–191} }
 @article{dworkin_2005, title={A  study of canalization and developmental stability in the sternopleural bristle system of Drosophila melanogaster}, volume={59}, number={7}, journal={Evolution}, author={Dworkin, I.}, year={2005}, pages={1500–1509} }
 @article{dworkin_2005, title={Evidence for canalization of Distal-less function in the leg of Drosophila melanogaster}, volume={7}, ISSN={["1520-541X"]}, DOI={10.1111/j.1525-142X.2005.05010.x}, abstractNote={Summary
					 A considerable body of theory pertaining to the evolution of canalization has emerged recently, yet there have been few empirical investigations of their predictions. To address this, patterns of canalization and trait correlation were investigated under the individual and joint effects of the introgression of a loss‐of‐function allele of the Distal‐less gene and high‐temperature stress on a panel of iso‐female lines. Variation was examined for number of sex comb teeth and the length of the basi‐tarsus on the pro‐thoracic leg of male Drosophila melanogaster. I demonstrate that whereas there is evidence for trait canalization, there is no evidence to support the hypothesis of the evolution of genetic canalization as a response to microenvironmental canalization. Furthermore, I demonstrate that although there are genetic correlations between these traits, there is no association between their measures of canalization. I discuss the prospects of the evolutionary lability of the Distal‐less gene within the context of changes in genetic variation and covariation.}, number={2}, journal={EVOLUTION & DEVELOPMENT}, author={Dworkin, I}, year={2005}, pages={89–100} }
 @article{dworkin_palsson_gibson_2005, title={Replication of an egfr-wing shape association in a wild-caught cohort of Drosaphila melanogaster}, volume={169}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.104.035766}, abstractNote={Abstract}, number={4}, journal={GENETICS}, author={Dworkin, I and Palsson, A and Gibson, G}, year={2005}, month={Apr}, pages={2115–2125} }
 @article{palsson_dodgson_dworkin_gibson_2005, title={Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology}, volume={6}, journal={BMC Genetics}, author={Palsson, A. and Dodgson, J. and Dworkin, I. and Gibson, G.}, year={2005} }
 @article{dworkin_2005, title={Towards a genetic architecture of cryptic genetic variation and genetic assimilation: The contribution of K.G. Bateman}, volume={84}, ISSN={["0022-1333"]}, DOI={10.1007/BF02715794}, number={3}, journal={JOURNAL OF GENETICS}, author={Dworkin, I}, year={2005}, month={Dec}, pages={223–226} }
 @article{palsson_rouse_riley-berger_dworkin_gibson_2004, title={Nucleotide variation in the Egfr locus of Drosophila melanogaster}, volume={167}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.104.026252}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Palsson, A and Rouse, A and Riley-Berger, R and Dworkin, I and Gibson, G}, year={2004}, month={Jul}, pages={1199–1212} }
 @misc{gibson_dworkin_2004, title={Uncovering cryptic genetic variation}, volume={5}, ISSN={["1471-0064"]}, DOI={10.1038/nrg1426}, abstractNote={Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations, and is thought to modify the penetrance of common diseases, the response of livestock and crops to artificial selection and the capacity of populations to respond to the emergence of a potentially advantageous macro-mutation. We argue in this review that cryptic genetic variation is pervasive but under-appreciated, we highlight recent progress in determining the nature and identity of genes that underlie cryptic genetic effects and we outline future research directions.}, number={9}, journal={NATURE REVIEWS GENETICS}, author={Gibson, G and Dworkin, I}, year={2004}, month={Sep}, pages={681–U11} }
 @article{dworkin_palsson_birdsall_gibson_2003, title={Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster}, volume={13}, ISSN={["1879-0445"]}, DOI={10.1016/j.cub.2003.10.001}, abstractNote={One objective of quantitative genetics is to identify the nucleotide variants within genes that contribute to phenotypic variation and susceptibility [1Stern D.L. Perspective evolutionary developmental biology and the problem of variation.Evolution. 2000; 54: 1079-1091PubMed Google Scholar]. In an evolutionary context, this means characterizing the molecular polymorphisms that modify the penetrance and expressivity of perturbed traits. A survey of association between 267 SNPs in almost 11 kb of the D. melanogaster Egfr and the degree of eye roughening due to a gain-of-function EgfrE1 allele crossed into 210 isogenic wild-type lines provides evidence that a handful of synonymous substitutions supply cryptic variation for photoreceptor determination. Ten sites exceed Bonferroni threshold for association in two sets of crosses to different EgfrE1 backgrounds including a particularly significant cluster of sites in tight linkage disequilibrium toward the 3′ end of the coding region. Epistatic interaction of this cluster with one other site enhances the expressivity of this haplotype. Replication of the strongest associations with an independent sample of 302 phenotypically extreme individuals derived from 1000 crosses of EgfrE1 to freshly trapped males was achieved using modified case-control and transmission-disequilibrium tests. A tendency for the rarer alleles to have more disrupted eye development suggests that mutation-selection balance is a possible mechanism contributing to maintaining cryptic variation for Egfr.}, number={21}, journal={CURRENT BIOLOGY}, author={Dworkin, I and Palsson, A and Birdsall, K and Gibson, G}, year={2003}, month={Oct}, pages={1888–1893} }