Christine N. Sinodis

Works (3)

Updated: July 5th, 2023 15:58

2006 article

Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth

Whitehurst, C. B., Willis, J. H., Sinodis, C. N., Hernandez, R., & Brown, D. T. (2006, January 5). Virology.

By: C. Whitehurst n, J. Willis  n, C. Sinodis n, R. Hernandez n & D. Brown n

author keywords: Sindis virus; E2 glycoprotein; transmembrane domain; virus assembly; compensatory mutations
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Cricetinae; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Deletion; Sindbis Virus / genetics; Sindbis Virus / growth & development; Sindbis Virus / physiology; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Virus Replication / genetics
topics (OpenAlex): Virology and Viral Diseases; Viral Infections and Outbreaks Research; Bacteriophages and microbial interactions
TL;DR: Results suggest that the position of the deletion and the length of the C terminal region of the E2 transmembrane domain is vital for normal virus production, and deletion mutants resulting in decreased infectivity produce particles that appear to be processed and transported correctly suggesting a role involved in virus entry. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Single amino acid insertions at the junction of the Sindbis virus e2 transmembrane domain and endodomain disrupt virus envelopment and alter infectivity

Christine N. Sinodis; Dennis Brown; Raquel Hernandez; Davis Ferreira

topics (OpenAlex):
Source: NC State University Libraries
Added: August 6, 2018

2003 article

Deletions in the Transmembrane Domain of a Sindbis Virus Glycoprotein Alter Virus Infectivity, Stability, and Host Range

Hernandez, R., Sinodis, C., Horton, M., Ferreira, D., Yang, C., & Brown, D. T. (2003, November 10). Journal of Virology.

By: R. Hernandez n, C. Sinodis n, M. Horton n, D. Ferreira n, C. Yang n & D. Brown n

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cricetinae; DNA Primers; Lipid Bilayers; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Sequence Homology, Amino Acid; Sindbis Virus / genetics; Sindbis Virus / physiology; Virus Assembly
topics (OpenAlex): Bacteriophages and microbial interactions; RNA and protein synthesis mechanisms; Viral gastroenteritis research and epidemiology
TL;DR: It is found that progressive truncations in the transmembrane domain profoundly affected production of infectious virus in a cyclic fashion and also found that membrane composition effects protein-protein and protein- Membrane interactions during virus assembly. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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