Christine N. Sinodis

Works (3)

Updated: July 5th, 2023 15:58

2006 journal article

Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth

VIROLOGY, 347(1), 199–207.

By: C. Whitehurst n, J. Willis  n, C. Sinodis n, R. Hernandez n & D. Brown n

author keywords: Sindis virus; E2 glycoprotein; transmembrane domain; virus assembly; compensatory mutations
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Cricetinae; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Deletion; Sindbis Virus / genetics; Sindbis Virus / growth & development; Sindbis Virus / physiology; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Virus Replication / genetics
TL;DR: Results suggest that the position of the deletion and the length of the C terminal region of the E2 transmembrane domain is vital for normal virus production, and deletion mutants resulting in decreased infectivity produce particles that appear to be processed and transported correctly suggesting a role involved in virus entry. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

Single amino acid insertions at the junction of the Sindbis virus e2 transmembrane domain and endodomain disrupt virus envelopment and alter infectivity

Journal of Virology, 79(12), 7682–7697.

By: R. Hernandez, D. Ferreira, C. Sinodis, K. Litton & D. Brown

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Deletions in the transmembrane domain of a Sindbis virus glycoprotein alter virus infectivity, stability, and host range

JOURNAL OF VIROLOGY, 77(23), 12710–12719.

By: R. Hernandez n, C. Sinodis n, M. Horton n, D. Ferreira n, C. Yang n & D. Brown n

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cricetinae; DNA Primers; Lipid Bilayers; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Sequence Homology, Amino Acid; Sindbis Virus / genetics; Sindbis Virus / physiology; Virus Assembly
TL;DR: It is found that progressive truncations in the transmembrane domain profoundly affected production of infectious virus in a cyclic fashion and also found that membrane composition effects protein-protein and protein- Membrane interactions during virus assembly. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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