Ronette Gehring

Works (11)

Updated: July 5th, 2023 15:58

2006 article

Application of risk assessment and management principles to the extralabel use of drugs in food‐producing animals

GEHRING, R., BAYNES, R. E., & RIVIERE, J. E. (2006, January 11). Journal of Veterinary Pharmacology and Therapeutics, Vol. 29, pp. 5–14.

By: R. Gehring n, R. Baynes n  & J. Riviere n

MeSH headings : Animals; Decision Trees; Drug Labeling; Drug Residues / adverse effects; Europe; Humans; Legislation, Food; Meat / analysis; Risk Assessment; United States; Veterinary Drugs / administration & dosage; Veterinary Drugs / adverse effects; Veterinary Drugs / analysis
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Agricultural safety and regulations; Animal testing and alternatives
TL;DR: This review describes how risk assessment principles can be extended to evaluate the risks posed by different classes of extralabel drug use and risk management practices in the United States and Europe are summarized and contrasted to illustrate the application of these principles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

A Physiologically Based Pharmacokinetic Model of Organophosphate Dermal Absorption

Merwe, D., Brooks, J. D., Gehring, R., Baynes, R. E., Monteiro-Riviere, N. A., & Riviere, J. E. (2005, October 12). Toxicological Sciences, Vol. 89, pp. 188–204.

By: D. Merwe*, J. Brooks n, R. Gehring n, R. Baynes n , N. Monteiro-Riviere n  & J. Riviere n

Contributors: D. Merwe*, J. Brooks n, R. Gehring n, R. Baynes n , N. Monteiro-Riviere n  & J. Riviere n

author keywords: dermal absorption; PBPK model; parathion; fenthion; methyl parathion
MeSH headings : Administration, Cutaneous; Animals; Dose-Response Relationship, Drug; Fenthion / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Methyl Parathion / pharmacokinetics; Models, Biological; Organothiophosphorus Compounds / pharmacokinetics; Parathion / pharmacokinetics; Risk Assessment; Skin / metabolism; Skin Absorption / physiology; Skin Physiological Phenomena; Solubility; Swine
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Essential Oils and Antimicrobial Activity; Pesticide Exposure and Toxicity
TL;DR: The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Aminoglycoside residues in food of animal origin

Gehring, R., Haskell, S. R., Payne, M. A., Craigmill, A. L., Webb, A. I., & Riviere, J. E. (2005, July 1). Journal of the American Veterinary Medical Association.

By: R. Gehring n, S. Haskell*, M. Payne*, A. Craigmill*, A. Webb* & J. Riviere n

MeSH headings : Aminoglycosides / analysis; Aminoglycosides / pharmacokinetics; Animals; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Consumer Product Safety; Drug Residues / analysis; Food Contamination / analysis; Legislation, Drug; Legislation, Veterinary; Meat / analysis; United States; Veterinary Drugs / adverse effects; Veterinary Drugs / therapeutic use
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pesticide Residue Analysis and Safety; Veterinary medicine and infectious diseases
TL;DR: The purpose of this digest is to give an overview of the pharmacokinetics and other properties of the aminoglycosides that contribute to these residues so that practitioners can better understand the food-safety risks of using these antimicrobials in foodproducing animals. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 article

Effect of formulation and route of administration on tissue residues and withdrawal times

KuKanich, B., Gehring, R., Webb, A. I., Craigmill, A. L., & Riviere, J. E. (2005, November 15). Journal of the American Veterinary Medical Association.

By: B. KuKanich, R. Gehring*, A. Webb, A. Craigmill & J. Riviere*

MeSH headings : Absorption; Animals; Dose-Response Relationship, Drug; Drug Administration Routes / veterinary; Drug Residues / analysis; Meat / analysis; Meat / standards; Tissue Distribution; United States; Veterinary Drugs / pharmacokinetics
topics (OpenAlex): Pesticide Residue Analysis and Safety; Pharmacogenetics and Drug Metabolism; Antibiotics Pharmacokinetics and Efficacy
TL;DR: A more thorough review of WDTs and tolerances and how they are determined has been published. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 article

Extralabel intramammary use of drugs in dairy cattle

Smith, G. W., Gehring, R., Craigmill, A. L., Webb, A. I., & Riviere, J. E. (2005, June 15). Journal of the American Veterinary Medical Association, Vol. 226, pp. 1994–1996.

By: G. Smith n , R. Gehring*, A. Craigmill, A. Webb & J. Riviere*

topics (OpenAlex): Microbial infections and disease research; Probiotics and Fermented Foods; Milk Quality and Mastitis in Dairy Cows
TL;DR: It is extremely important for vetinarians to maintain good records and follow extended withdrawal intervals when using intramam-mary administration of drugs in an extralabel manner to ensure food safety andavoid residue violations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle

Gehring, R., Merwe, D., Pierce, A. N., Baynes, R. E., Craigmill, A. L., & Riviere, J. E. (2005, January 1). American Journal of Veterinary Research, Vol. 66, pp. 108–112.

By: R. Gehring*, D. Merwe n, A. Pierce  n, R. Baynes n , A. Craigmill n & J. Riviere n

MeSH headings : Ampicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / pharmacokinetics; Cattle / metabolism; Cluster Analysis; Multivariate Analysis
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Veterinary medicine and infectious diseases; Mycobacterium research and diagnosis
TL;DR: Meta-analysis was successful in detecting a potential subpopulation of cattle for which factors that explained differences in pharmacokinetic parameters could be identified. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

A web-based decision support system to estimate extended withdrawal intervals

Gehring, R., Baynes, R. E., Wang, J., Craigmill, A. L., & Riviere, J. E. (2004, July 20). Computers and Electronics in Agriculture, Vol. 44, pp. 145–151.

By: R. Gehring n, R. Baynes n , J. Wang n, A. Craigmill* & J. Riviere n

author keywords: withdrawal times; extralabel drug use; drug residues; veterinary medicine
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pesticide Residue Analysis and Safety; Analytical Methods in Pharmaceuticals
TL;DR: A web-based application was developed to facilitate the calculation of extended withdrawal intervals based on information in the databases maintained by members of the Food Animal Residue Avoidance Databank (FARAD) and using the Extrapolated Withdrawal Interval Estimator (EWE) algorithm. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows

Journal of the American Veterinary Medical Association, 224(11), 1827–1830.

By: G. Smith n , R. Gehring*, J. Riviere*, J. Yeatts* & R. Baynes* 

MeSH headings : Animals; Anti-Infective Agents, Local / administration & dosage; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / pharmacokinetics; Cattle; Cephalosporins / administration & dosage; Cephalosporins / analysis; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Milk / chemistry; Prospective Studies; Reagent Kits, Diagnostic / veterinary
topics (OpenAlex): Milk Quality and Mastitis in Dairy Cows; Organ and Tissue Transplantation Research
TL;DR: Ceftiofur administered by the intramammary route as an extra-label treatment for mastitis in dairy cows reaches concentrations in milk greater than the tolerance set by the FDA. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2004 article

Feasibility of Using Half-Life Multipliers To Estimate Extended Withdrawal Intervals following the Extralabel Use of Drugs in Food-Producing Animals

Gehring, R., Baynes, R. E., Craigmill, A. L., & Riviere, J. E. (2004, March 1). Journal of Food Protection, Vol. 67, pp. 555–560.

By: R. Gehring n, R. Baynes n , A. Craigmill* & J. Riviere n

MeSH headings : Algorithms; Animals; Animals, Domestic / metabolism; Drug Residues / analysis; Drug Residues / pharmacokinetics; Food Contamination / prevention & control; Half-Life; Legislation, Drug; Legislation, Veterinary; Meat / analysis; Models, Biological; Time Factors; United States; Veterinary Drugs / pharmacokinetics
topics (OpenAlex): Animal testing and alternatives; Analytical Methods in Pharmaceuticals; Pesticide Residue Analysis and Safety
TL;DR: For the group of drugs investigated, a half-life multiplier of 5 resulted in estimates of extended withdrawal intervals that were potentially inadequate to prevent violative tissue residues for drugs that had relatively long tissue half- Lives, high tolerances, or both. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Meta‐analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G

Craigmill, A. L., Miller, G. R., Gehring, R., Pierce, A. N., & Riviere, J. E. (2004, October 1). Journal of Veterinary Pharmacology and Therapeutics.

By: A. Craigmill*, G. Miller*, R. Gehring n, A. Pierce * & J. Riviere n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Cattle / metabolism; Databases, Factual; Drug Residues / analysis; Injections, Intramuscular / veterinary; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics; Oxytetracycline / pharmacology; Penicillin G Procaine / administration & dosage; Penicillin G Procaine / blood; Penicillin G Procaine / pharmacokinetics; Penicillin G Procaine / pharmacology; United States; United States Department of Agriculture
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pesticide Residue Analysis and Safety; Pharmaceutical and Antibiotic Environmental Impacts
TL;DR: A combination approach to meta-analysis of published mean data is recommended, where the TSM is the first step, followed by the NMEM approach, and all three methods generate comparable mean parameter estimates for OTC and PPG. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank

Wang, J., Gehring, R., Baynes, R. E., Webb, A. I., Whitford, C., Payne, M. A., … Riviere, J. E. (2003, December 1). Journal of the American Veterinary Medical Association, Vol. 223, pp. 1596–1598.

By: J. Wang n, R. Gehring n, R. Baynes n , A. Webb*, C. Whitford*, M. Payne*, K. Fitzgerald *, A. Craigmill*, J. Riviere n

MeSH headings : Animal Husbandry; Animals; Consumer Product Safety; Data Collection; Databases, Factual; Drug Approval; Drug Labeling; Drug Residues; Electronic Mail; Food Contamination / prevention & control; Humans; Information Systems; Telephone; United States; Veterinary Drugs / therapeutic use
topics (OpenAlex): Identification and Quantification in Food; Food Safety and Hygiene; Pesticide Residue Analysis and Safety
TL;DR: The Food Animal Residue Avoidance Databank (FARAD) offers expert-mediated advice on residue avoidance and mitigation for chemical contamination incidents and the extralabel use of drugs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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