Bashir Mir

Works (9)

Updated: July 5th, 2023 15:58

2011 journal article

Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration

British Journal of Ophthalmology, 95(12), 1749–1754.

By: J. Sommer n, J. Estrada n, E. Collins n, M. Bedell *, C. Alexander n, Z. Yang *, G. Hughes*, B. Mir n ...

MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR: These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ)

ANIMAL BIOTECHNOLOGY, 19(1), 6–21.

By: G. Zaunbrecher*, B. Mir n, P. Dunne*, M. Breen n  & J. Piedrahita n 

Contributors: G. Zaunbrecher*, P. Dunne*, B. Mir n, M. Breen n  & J. Piedrahita n 

author keywords: extra chromosomal; homologous recombination; somatic cells
MeSH headings : Acetyltransferases / genetics; Animals; Cell Physiological Phenomena; Chromosomes / genetics; DNA Primers; DNA Repair; Plasmids; Recombination, Genetic; Swine; Tumor Suppressor Protein p53 / genetics
TL;DR: Results show that attempts at reducing NHEJ by use of Mre11 or anti-Ku aptamers were unsuccessful, and cell synchrony via thymidine incorporation does increase the ratio of HR/NHEJ and this indicates that this approach may be of use to facilitate targeting in somatic cells by reducing the numbers of colonies that need to be analyzed before a HR is identified. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR)

CLONING AND STEM CELLS, 9(2), 229–236.

By: J. Estrada n, J. Sommer n, B. Collins n, B. Mir n, A. Martin n, A. York n, R. Petters n, J. Piedrahita n 

MeSH headings : Animals; Birth Weight / physiology; Fetal Growth Retardation; Insemination, Artificial; Litter Size / physiology; Nuclear Transfer Techniques; Swine
TL;DR: SCNT-derived pigs are excellent models to study epigenetic factors and genes involved in IUGRs, and to develop effective means to improve fetal growth in humans and animals, and there are some differences between SCNT- derived and AI litters. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Detection of transcriptional difference of porcine imprinted genes using different microarray platforms

BMC Genomics, 7.

By: S. Tsai, B. Mir, A. Martin, J. Estrada, S. Bischoff, W. Hsieh, J. Cassady, B. Freking ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Progeny of somatic cell nuclear transfer (SCNT) pig clones are phenotypically similar to non-cloned pigs

CLONING AND STEM CELLS, 7(2), 119–125.

By: B. Mir n, G. Zaunbrecher*, G. Archer *, T. Friend* & J. Piedrahita n 

MeSH headings : Animals; Body Weight; Cloning, Organism; Female; Litter Size; Male; Nuclear Transfer Techniques; Phenotype; Sex Ratio; Swine / genetics
TL;DR: The hypothesis that offspring of clones are similar to offspring of naturally bred animals, and as such there should not be any increased risks associated with consumption of products from these animals, is strongly supported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Cloning and transgenesis in mammals: Implications for xenotransplantation

AMERICAN JOURNAL OF TRANSPLANTATION, 4, 43–50.

By: J. Piedrahita n  & B. Mir n

MeSH headings : Animals; Animals, Genetically Modified; Cloning, Organism; Embryo, Mammalian / cytology; Graft Rejection / etiology; Graft Rejection / immunology; Graft Rejection / prevention & control; Humans; Immune Tolerance; Immunosuppression Therapy; Nuclear Transfer Techniques; Stem Cells / cytology; Swine; Transplantation, Heterologous / immunology; Transplantation, Heterologous / methods; Transplantation, Heterologous / trends
TL;DR: Advances in transgenic manipulation and cloning in swine are reviewed and how the development of these two technologies is critical to the eventual utilization of the pig as a human organ donor. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Nuclear localization signal and cell synchrony enhance gene targeting efficiency in primary fetal fibroblasts

Nucleic Acids Research, 32(3).

By: B. Mir & J. Piedrahita 

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Somatic cell cloning: The ultimate form of nuclear reprogramming?

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 15(5), 1140–1144.

By: J. Piedrahita n , B. Mir n, S. Dindot n & S. Walker*

MeSH headings : Animals; Cloning, Molecular / methods; Humans; Kidney Failure, Chronic / therapy; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR: To make this a reality, techniques associated with cloning and genetic modifications in somatic cells need to be continued to be developed and optimized and have an effect beyond the area of nuclear transfer and assist with better methods for transdifferentiation of mammalian cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

UP1 extends life of primary porcine fetal fibroblasts in culture

CLONING AND STEM CELLS, 5(2), 143–148.

By: B. Mir n, N. Tanner*, B. Chowdhary* & J. Piedrahita n 

MeSH headings : Animals; Antioxidants / pharmacology; Cell Survival / drug effects; Cells, Cultured; Chromosome Aberrations; Culture; Electroporation; Fetus / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Glutathione / pharmacology; Heterogeneous-Nuclear Ribonucleoprotein Group A-B / genetics; Heterogeneous-Nuclear Ribonucleoprotein Group A-B / metabolism; Hydroxylamines / pharmacology; Karyotyping; Swine / embryology
TL;DR: Effect of two anti-oxidants, glutathione and n-t-butyl hydroxylamine, and of the expression of UP1, a shortened derivative of heterogeneous nuclear riboprotein (hnRNP)A1, on the life extension of primary porcine fibroblasts in culture is reported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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