Kellee R. Griffin

Works (1)

Updated: July 5th, 2023 15:58

2004 article

The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu5]-enkephalin from coumarin prodrug moieties

Zych, L. A., Yang, W., Liao, Y., Griffin, K. R., & Wang, B. (2004, January 16). Bioorganic Chemistry.

By: L. Zych n, W. Yang n, Y. Liao n, K. Griffin n & B. Wang n

author keywords: coumarin; cyclic prodrug; opioid peptide; esterase; structural effect
MeSH headings : Coumarins / chemistry; Coumarins / metabolism; Enkephalin, Leucine-2-Alanine / analogs & derivatives; Enkephalin, Leucine-2-Alanine / chemical synthesis; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / metabolism; Enkephalins / chemical synthesis; Enkephalins / chemistry; Enkephalins / metabolism; Esterases / metabolism; Kinetics; Molecular Structure; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism
topics (OpenAlex): Neuropeptides and Animal Physiology; Receptor Mechanisms and Signaling; Chemical Synthesis and Analysis
TL;DR: Aimed at further understanding the structure-release rate relationship of the coumarin-based cyclic prodrugs, a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu(5)]-enkephalin are synthesized and examined. (via Semantic Scholar)
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Added: August 6, 2018

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