Joseph Sturino

Works (5)

Updated: July 5th, 2023 15:58

2007 journal article

Inhibition of bacteriophage replication in Streptococcus thermophilus by subunit poisoning of primase

MICROBIOLOGY-SGM, 153, 3295–3302.

By: J. Sturino n & T. Klaenhammer n

MeSH headings : Amino Acid Sequence; Amino Acid Substitution / genetics; Codon, Nonsense; DNA Primase / antagonists & inhibitors; DNA Primase / genetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protein Subunits / genetics; Streptococcus Phages / growth & development; Streptococcus thermophilus / virology; Viral Plaque Assay; Virus Replication / physiology
TL;DR: This study appears to represent the first use of transdominant proteins to inhibit phages that are disruptive to cultures used in industrial fermentations. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 review

Engineered bacteriophage-defence systems in bioprocessing

[Review of ]. NATURE REVIEWS MICROBIOLOGY, 4(5), 395–404.

By: J. Sturino n & T. Klaenhammer n

MeSH headings : Bacteria / genetics; Bacteria / virology; Bacteriophages / physiology; Biotechnology; Dairy Products; Fermentation; Food Microbiology; Genetic Engineering; Genomics; RNA, Antisense; Streptococcus / genetics; Streptococcus / physiology; Streptococcus / virology; Streptococcus Phages / genetics; Streptococcus Phages / physiology; Virus Replication
TL;DR: A set of genetic tools that are useful in the engineering of customized phage-defence systems are described, with special focus on the power of comparative genomics as a means of streamlining target selection, providing more widespread phage protection, and increasing the longevity of these industrially important bacteria in the bioprocessing environment. (via Semantic Scholar)
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2004 patent

Antisense RNA expression strategies effective against Streptococcus thermophilus bacteriophages

Washington, DC: U.S. Patent and Trademark Office.

By: J. Sturino & T. Klaenhammer

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Antisense RNA targeting of primase interferes with bacteriophage replication in Streptococcus thermophilus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(3), 1735–1743.

By: J. Sturino n & T. Klaenhammer n

MeSH headings : Base Sequence; DNA Primase / genetics; DNA Replication; DNA, Viral / genetics; Genes, Viral; Genetic Vectors; Molecular Sequence Data; Mutation; RNA, Antisense / genetics; RNA, Viral / genetics; Streptococcus / virology; Streptococcus Phages / enzymology; Streptococcus Phages / genetics; Streptococcus Phages / physiology; Virus Replication
TL;DR: Targeting a key genome replication function with antisense RNA provided effective phage protection in S. thermophilus. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 review

Bacteriophage defense systems and strategies for lactic acid bacteria

[Review of ]. ADVANCES IN APPLIED MICROBIOLOGY, VOL 56, 56, 331-+.

By: J. Sturino* & T. Klaenhammer n

MeSH headings : Animals; Bacteriophages / genetics; Bacteriophages / physiology; Cattle; Dairying; Humans; Lactococcus lactis / genetics; Lactococcus lactis / virology; Streptococcus Phages / genetics; Streptococcus Phages / physiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology
TL;DR: This chapter highlights the various defense strategies and systems that have been developed to curb the propagation and evolution of lytic phages in S. thermophilus and their bacteriophages. (via Semantic Scholar)
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Added: August 6, 2018

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