Sarah Jane Fry

Works (1)

Updated: July 5th, 2023 15:58

2004 journal article

Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(14), 13911–13924.

By: K. Moorefield n, S. Fry n & J. Horowitz n

MeSH headings : Animals; Base Sequence; COS Cells; Consensus Sequence; Cricetinae; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Epithelial Cells / cytology; Epithelial Cells / physiology; Humans; Male; Mammals; Mice; Promoter Regions, Genetic / physiology; Prostate / cytology; Prostate-Specific Antigen / genetics; Protein Structure, Tertiary; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / genetics; Sp1 Transcription Factor / metabolism; Sp2 Transcription Factor; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic / physiology
TL;DR: Sp2 is functionally distinct relative to other Sp family members and suggest that Sp2 may play a unique role in cell physiology, using chimeric molecules prepared with portions of Sp1 and Sp2 and the human prostate-specific antigen promoter. (via Semantic Scholar)
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