@article{yoon_zhu_ewing_smart_2007, title={Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function}, volume={26}, ISSN={["1476-5594"]}, DOI={10.1038/sj.onc.1209797}, abstractNote={Recent studies have identified roles for C/EBPbeta in cellular survival and tumorigenesis, however, the mechanisms through which C/EBPbeta regulates these processes are not fully understood. Previously, we demonstrated that C/EBPbeta(-/-) mice are resistant to carcinogen-induced skin tumorigenesis and in response to topical carcinogen treatment display a 17-fold increase in keratinocyte apoptosis compared to wild-type mice. Here, we have investigated the mechanisms through which C/EBPbeta regulates apoptosis in response to carcinogenic stress. Analysis of carcinogen-treated C/EBPbeta(-/-) mouse skin revealed a striking increase in the number of p53 immunopositive keratinocytes in the epidermis of C/EBPbeta(-/-) mice compared to wild-type mice and this increase was temporally associated with a concomitant anomalous increase in apoptosis. The increased levels of p53 were functional as Mdm2, Bcl-2, C/EBPalpha and p21 were differentially regulated in the epidermis of carcinogen-treated C/EBPbeta(-/-) mice. The increase in p53 protein was not associated with an increase in p53 mRNA levels. To determine whether p53 is required for the increased apoptosis in C/EBPbeta(-/-) mice, C/EBPbeta/p53 compound knockout mice were generated. Carcinogen-treated C/EBPbeta/p53 compound knockout mice did not display increased apoptosis demonstrating p53 is required for the proapoptotic phenotype in C/EBPbeta(-/-) mice. Our results demonstrate that altered keratinocyte survival in C/EBPbeta(-/-) mice results from aberrant regulation of p53 protein and function and indicate C/EBPbeta has a role in the negative regulation of p53 protein levels in response to carcinogen-induced stress.}, number={3}, journal={ONCOGENE}, author={Yoon, K. and Zhu, S. and Ewing, S. J. and Smart, R. C.}, year={2007}, month={Jan}, pages={360–367} }
 @article{shim_powers_ewing_zhu_smart_2005, title={Diminished expression of C/EBP alpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBP alpha in carcinoma cells inhibits proliferation}, volume={65}, number={3}, journal={Cancer Research}, author={Shim, M. and Powers, K. L. and Ewing, S. J. and Zhu, S. and Smart, R. C.}, year={2005}, pages={861–867} }
 @article{ewing_kowalsky_2004, title={Compressive behavior of unconfined and confined clay brick masonry}, volume={130}, DOI={10.1061/(asce)0733-9445(2004)130:4(650)}, abstractNote={Presented in this paper are the results of an investigation of the compressive behavior of grouted clay brick masonry prisms. The objective is to experimentally capture the stress–strain characteristics of unconfined and confined clay brick masonry and compare the response with that predicted with the “modified” Kent–Park stress–strain curve. Based on the experimental results, five limit states for clay brick masonry in compression are proposed, as well as equivalent stress blocks for design. Thin galvanized steel plates placed in the mortar joints during construction provided prism confinement. The variables considered included volumetric ratio of confining steel (0, ∼0.015, and ∼0.03) and the presence of machined holes within the confinement plates to improve the bond between the masonry and steel plate. It is shown that confinement plates are extremely effective in enhancing the ultimate compressive strength as well as increasing the deformation capacity of the clay brick masonry prisms. The use of con...}, number={4}, journal={Journal of Structural Engineering (New York, N.Y.)}, author={Ewing, B. D. and Kowalsky, M. J.}, year={2004}, pages={650–661} }