Jonathan P. Jackson

MeSH headings : Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Gene Expression Regulation, Enzymologic / drug effects; Liver / metabolism; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Phenobarbital / pharmacology; Phenytoin / pharmacology; Pregnane X Receptor; Pregnenolone Carbonitrile / pharmacology; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / deficiency; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Steroid / deficiency; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Transcription Factors / deficiency; Transcription Factors / genetics; Transcription Factors / metabolism

TL;DR: It is reported that murine CYP2C37 mRNA is induced by phenobarbital and phenytoin, suggesting that PXR does not regulate this gene, and induction of Cyp2c37 by these xenobiotics is CAR-dependent. (via Semantic Scholar)

MeSH headings : Active Transport, Cell Nucleus; Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P450 Family 2; Enzyme Induction / drug effects; Humans; Mice; Mice, Inbred C57BL; Oxygenases / biosynthesis; Oxygenases / genetics; Phenytoin / pharmacology; Protein Binding; RNA, Messenger / biosynthesis; RNA, Messenger / drug effects; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Steroid / metabolism; Transcription Factors / metabolism

TL;DR: The constitutive levels of CYP2C29 mRNA were reduced approximately 77-fold in CAR-null mice compared with those in the wild-type mice, suggesting that CAR may also regulate the constitutive expression of the Cyp2c29 gene either directly or indirectly. (via Semantic Scholar)