Works (1)
Updated: July 5th, 2023 15:58
2004 journal article
Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191–L200.
author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
TL;DR:
The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways.
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