Donnie E. Shifflett

Works (3)

Updated: July 5th, 2023 15:58

2004 journal article

CIC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

GASTROENTEROLOGY, 127(3), 802–815.

By: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

Contributors: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / metabolism; Chlorides / metabolism; Dinoprostone / pharmacology; Electric Impedance; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Male; Models, Animal; Permeability / drug effects; Prostaglandins / pharmacology; Recovery of Function / drug effects; Recovery of Function / physiology; Swine
TL;DR: ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine and may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.

By: D. Shifflett n, F. Bottone, K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
TL;DR: PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(2), G399–G407.

By: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

Contributors: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

author keywords: mucosa; barrier function; deoxycholic acid; tight junction
MeSH headings : Animals; Bile Acids and Salts / analysis; Calcium / metabolism; Deoxycholic Acid / pharmacology; Female; Ileum / blood supply; Ileum / chemistry; Ileum / pathology; Ileum / physiopathology; Ischemia / metabolism; Ischemia / pathology; Ischemia / physiopathology; Male; Microscopy, Electron; Osmolar Concentration; Permeability / drug effects; Recovery of Function / drug effects; Swine; Taurodeoxycholic Acid / pharmacology
TL;DR: Deoxycholic acid at physiological concentrations significantly impairs recovery of epithelial barrier function by an effect on paracellular pathways, and these effects appear to be Ca(2+) dependent. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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