Donnie E. Shifflett

Works (3)

Updated: July 5th, 2023 15:58

2004 article

ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

Moeser, A. J., Haskell, M. M., Shifflett, D. E., Little, D., Schultz, B. D., & Blikslager, A. T. (2004, September 1). Gastroenterology, Vol. 127, pp. 802–815.

By: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

Contributors: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / metabolism; Chlorides / metabolism; Dinoprostone / pharmacology; Electric Impedance; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Male; Models, Animal; Permeability / drug effects; Prostaglandins / pharmacology; Recovery of Function / drug effects; Recovery of Function / physiology; Swine
topics (OpenAlex): Barrier Structure and Function Studies; Neuroscience and Neuropharmacology Research; Ion Transport and Channel Regulation
TL;DR: ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine and may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.

By: D. Shifflett n, F. Bottone, K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, S. Jones*  & A. Blikslager* 

author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
topics (OpenAlex): S100 Proteins and Annexins; Intensive Care Unit Cognitive Disorders; Immune Response and Inflammation
TL;DR: PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(2), G399–G407.

By: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

Contributors: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

author keywords: mucosa; barrier function; deoxycholic acid; tight junction
MeSH headings : Animals; Bile Acids and Salts / analysis; Calcium / metabolism; Deoxycholic Acid / pharmacology; Female; Ileum / blood supply; Ileum / chemistry; Ileum / pathology; Ileum / physiopathology; Ischemia / metabolism; Ischemia / pathology; Ischemia / physiopathology; Male; Microscopy, Electron; Osmolar Concentration; Permeability / drug effects; Recovery of Function / drug effects; Swine; Taurodeoxycholic Acid / pharmacology
topics (OpenAlex): Biochemical effects in animals; Cardiac Ischemia and Reperfusion; Anesthesia and Neurotoxicity Research
TL;DR: Deoxycholic acid at physiological concentrations significantly impairs recovery of epithelial barrier function by an effect on paracellular pathways, and these effects appear to be Ca(2+) dependent. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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