M. Andrea Azcarate-Peril

Works (13)

Updated: July 19th, 2023 21:16

2010 article

Role of Antioxidant Enzymes in Bacterial Resistance to Organic Acids

Bruno-Bárcena Jose M., Azcárate-Peril M. Andrea, & Hassan, H. M. (2010, March 20). Applied and Environmental Microbiology, Vol. 76, pp. 2747–2753.

By: J. Bruno-Bárcena n , M. Azcárate-Peril* & H. Hassan* 

Contributors: J. Bruno-Bárcena n , M. Andrea Azcárate-Peril* & H. Hassan* 

MeSH headings : Antioxidants / metabolism; Antioxidants / physiology; Bacterial Proteins / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Hydrogen-Ion Concentration; Iron / metabolism; Lactic Acid / toxicity; Oxidative Stress; Streptococcus thermophilus / drug effects; Streptococcus thermophilus / enzymology; Stress, Physiological; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Superoxide Dismutase / physiology
topics (OpenAlex): Bacterial biofilms and quorum sensing; Bacterial Genetics and Biotechnology; Antibiotic Resistance in Bacteria
TL;DR: It is suggested that acid stress triggers an iron-mediated oxidative stress that can be ameliorated by MnSOD and iron chelators and may explain the ability of some microorganisms to survive better in acidified environments, as in acid foods during fermentation and accumulation of lactic acid or during passage through the low pH of the stomach. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 patent

Compositions comprising promoter sequences and methods of use

By: R. Barrangou , A. Azcarate-Peril, E. Altermann, T. Duong & T. Klaenhammer

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Development and Application of a upp -Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM

Goh, Y. J., Azcárate-Peril, M. A., O'Flaherty, S., Durmaz, E., Valence, F., Jardin, J., … Klaenhammer, T. R. (2009, March 21). Applied and Environmental Microbiology.

By: Y. Goh n, M. Azcárate-Peril n, S. O'Flaherty n, E. Durmaz n, F. Valence *, J. Jardin *, S. Lortal*, T. Klaenhammer n

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
topics (OpenAlex): Probiotics and Fermented Foods; Bacteriophages and microbial interactions; Bacterial Genetics and Biotechnology
TL;DR: Use of the upp-encoded uracil phosphoribosyltransferase (UPRTase) of L. acidophilus NCFM was explored as a counterselection marker to positively select for recombinants that have resolved from chromosomal integration of pORI-based plasmids. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 patent

Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor

By: T. Klaenhammer, W. Russell, E. Altermann & A. Azcarate-Peril

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Role of autoinducer-2 on the adhesion ability ofLactobacillus acidophilus

Buck, B. L., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2009, March 16). Journal of Applied Microbiology.

By: B. Buck n, M. Azcarate-Peril n & T. Klaenhammer n

author keywords: autoinducer-2; Caco-2; microarray; probiotic
MeSH headings : Bacterial Adhesion / genetics; Bacterial Proteins / genetics; Caco-2 Cells / microbiology; Carbon-Sulfur Lyases / genetics; DNA, Bacterial / genetics; Gene Expression Regulation, Bacterial; Homoserine / analogs & derivatives; Homoserine / genetics; Homoserine / metabolism; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Lactones / metabolism; Microarray Analysis; Mutation; Phylogeny; Quorum Sensing / genetics; RNA, Bacterial / genetics
topics (OpenAlex): Bacterial biofilms and quorum sensing; Probiotics and Fermented Foods; Antimicrobial Peptides and Activities
TL;DR: Investigating whether or not the quorum‐sensing signalling molecule, autoinducer (AI)‐2, was produced by Lactobacillus acidophilus and affected adherence to intestinal epithelial cells found it likely promotes retention in the gastrointestinal tract and communication with the immune system. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 patent

Lactobacillus acidophilus nucleic acids and uses thereof

By: T. Klaenhammer, A. Azcarate-Peril & E. Altermann

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Characterization of a Novel Bile-Inducible Operon Encoding a Two-Component Regulatory System inLactobacillus acidophilus

Pfeiler, E. A., Azcarate-Peril, M. A., & Klaenhammer, T. R. (2007, April 21). Journal of Bacteriology.

By: E. Pfeiler n, M. Azcarate-Peril n & T. Klaenhammer n

MeSH headings : Bacterial Proteins / genetics; Base Sequence; Bile Acids and Salts / pharmacology; Gene Expression Regulation, Bacterial / drug effects; Gene Order; Genes, Bacterial / genetics; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / drug effects
topics (OpenAlex): Bacterial Genetics and Biotechnology; Probiotics and Fermented Foods; Escherichia coli research studies
TL;DR: Functional analysis of the effects of bile on the global transcriptional profile of lactobacillus acidophilus NCFM showed that the operon encoded proteins involved in both bile tolerance and bile sensitivity, indicating that the 2CRS plays a role in bileolerance and that theOperon it resides in is negatively controlled by the RR. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Influence of the Dairy Environment on Gene Expression and Substrate Utilization in Lactic Acid Bacteria1, ,

Klaenhammer, T. R., Azcarate-Peril, M. A., Altermann, E., & Barrangou, R. (2007, March 1). Journal of Nutrition, Vol. 137, pp. 748S–750.

By: T. Klaenhammer n, M. Azcarate-Peril n, E. Altermann n & R. Barrangou n 

MeSH headings : Animals; Cattle; Dairy Products; Dairying; Environment; Gene Expression Regulation, Bacterial; Lactobacillaceae / genetics; Lactobacillaceae / metabolism; Probiotics
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: Comparative genomics between multiple genomes is providing insights into genes that are important in metabolic, physiological, and functional roles for different LAB in the environments they inhabit, ranging from the gastrointestinal tract to milk and acidified dairy products. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays

Barrangou, R., Azcarate-Peril, M. A., Duong, T., Conners, S. B., Kelly, R. M., & Klaenhammer, T. R. (2006, February 27). Proceedings of the National Academy of Sciences, Vol. 103, pp. 3816–3821.

By: R. Barrangou n , M. Azcarate-Peril n, T. Duong  n, S. Conners n, R. Kelly n  & T. Klaenhammer n

author keywords: ATP-binding cassette; carbon catabolite repression; fructooligosaccharide; galactoside-pentose hexuronide
MeSH headings : ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Carbohydrate Metabolism / genetics; Gastrointestinal Tract / microbiology; Gene Expression Profiling; Genes, Bacterial; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Models, Biological; Oligonucleotide Array Sequence Analysis; Phosphoenolpyruvate Sugar Phosphotransferase System / genetics; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Biochemical Analysis and Sensing Techniques
TL;DR: The transport and catabolic machinery involved in carbohydrate utilization by Lactobacillus acidophilus was characterized genetically by using whole-genome cDNA microarrays, and genes central to glycolysis were among the most highly expressed in the genome. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Genomic Perspectives on Probiotic Lactic Acid Bacteria

Klaenhammer, T. R., Peril, A. A., Barrangou, R., Duong, T., & Altermann, E. (2005, January 1). Bioscience and Microflora, Vol. 24, pp. 31–33.

By: T. Klaenhammer n, A. Peril n, R. Barrangou n , T. Duong n & E. Altermann n

topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: The genomic content of probiotic Lactobacillus cultures is examined, compared to those lactic acid bacterial genomes that have appeared recently, to illustrate how environmental conditions encountered during biomanufacturing, fermentation, and the gastrointestinal tract can impact gene expression and culture functionality. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Genomic features of lactic acid bacteria effecting bioprocessing and health

KLAENHAMMER, T., BARRANGOU, R., BUCK, B., AZCARATEPERIL, M., & ALTERMANN, E. (2005, May 25). FEMS Microbiology Reviews, Vol. 29, pp. 393–409.

By: T. Klaenhammer n, R. Barrangou n , B. Buck n, M. Azcarateperil n & E. Altermann n

author keywords: lactic acid bacteria; genomics; bioprocessing; probiotics; comparative genomics; functional genomics
MeSH headings : Food Microbiology; Genome, Bacterial; Genomics; Health; Humans; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactococcus / genetics; Lactococcus / growth & development; Lactococcus / physiology; Probiotics
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: Genomic analyses of multiple members of the lactic acid bacteria have now elucidated many genetic features that direct their fermentative and probiotic roles, providing an important platform for understanding core mechanisms that control and regulate bacterial growth, survival, signaling, and fermentative processes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Marker-free chromosomal integration of the manganese superoxide dismutase gene (sodA) fromStreptococcus thermophilusintoLactobacillus gasseri

Bruno-Bárcena, J. Ã. M., Azcárate-Peril, M. A., Klaenhammer, T. R., & Hassan, H. M. (2005, April 8). FEMS Microbiology Letters, Vol. 246, pp. 91–101.

By: J. Bruno-Bárcena n, M. Azcárate-Peril n, T. Klaenhammer n & H. Hassan n 

Contributors: J. Bruno-Bárcena n , M. Azcárate-Peril n, T. Klaenhammer n & H. Hassan n 

author keywords: functional gene replacement; manganese superoxide dismutase; oxidative stress; Lactobacillus gasseri; lactic acid bacteria; probiotics
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / analysis; Chromosomes, Bacterial / genetics; Gene Expression; Hydrogen Peroxide / pharmacology; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Plasmids / genetics; RNA, Bacterial / analysis; RNA, Messenger / analysis; Streptococcus thermophilus / enzymology; Streptococcus thermophilus / genetics; Superoxide Dismutase / genetics; Transformation, Bacterial
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Bacterial Genetics and Biotechnology; Probiotics and Fermented Foods
TL;DR: This is the first report showing the successful utilization of the pORI plasmids system to generate marker-free gene integration in L. gasseri strains. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 article

Identification and Inactivation of Genetic Loci Involved withLactobacillus acidophilusAcid Tolerance

Azcarate-Peril, M. A., Altermann, E., Hoover-Fitzula, R. L., Cano, R. J., & Klaenhammer, T. R. (2004, September 1). Applied and Environmental Microbiology.

By: M. Azcarate-Peril n, E. Altermann n, R. Hoover-Fitzula n, R. Cano * & T. Klaenhammer n

MeSH headings : Base Sequence; Calorimetry; DNA Primers; Genome, Bacterial; Hydrogen-Ion Concentration; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Molecular Sequence Data; Polymerase Chain Reaction; Restriction Mapping
topics (OpenAlex): Polyamine Metabolism and Applications; Probiotics and Fermented Foods; Amino Acid Enzymes and Metabolism
TL;DR: Interestingly, each integrant also exhibited an adaptive acid response during logarithmic growth, indicating that multiple mechanisms are present and orchestrated in L. acidophilus in response to acid challenge. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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