Works (13)
Updated: July 19th, 2023 21:16
2010 journal article
Role of Antioxidant Enzymes in Bacterial Resistance to Organic Acids
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(9), 2747–2753.
Contributors: J. Bruno-Bárcena n , M. Andrea Azcárate-Peril* & H. Hassan*
MeSH headings : Antioxidants / metabolism; Antioxidants / physiology; Bacterial Proteins / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Hydrogen-Ion Concentration; Iron / metabolism; Lactic Acid / toxicity; Oxidative Stress; Streptococcus thermophilus / drug effects; Streptococcus thermophilus / enzymology; Stress, Physiological; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Superoxide Dismutase / physiology
TL;DR:
It is suggested that acid stress triggers an iron-mediated oxidative stress that can be ameliorated by MnSOD and iron chelators and may explain the ability of some microorganisms to survive better in acidified environments, as in acid foods during fermentation and accumulation of lactic acid or during passage through the low pH of the stomach.
(via Semantic Scholar)
aem.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 patent
Compositions comprising promoter sequences and methods of use
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
TL;DR:
Use of the upp-encoded uracil phosphoribosyltransferase (UPRTase) of L. acidophilus NCFM was explored as a counterselection marker to positively select for recombinants that have resolved from chromosomal integration of pORI-based plasmids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 patent
Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus
JOURNAL OF APPLIED MICROBIOLOGY, 107(1), 269–279.
author keywords: autoinducer-2; Caco-2; microarray; probiotic
MeSH headings : Bacterial Adhesion / genetics; Bacterial Proteins / genetics; Caco-2 Cells / microbiology; Carbon-Sulfur Lyases / genetics; DNA, Bacterial / genetics; Gene Expression Regulation, Bacterial; Homoserine / analogs & derivatives; Homoserine / genetics; Homoserine / metabolism; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Lactones / metabolism; Microarray Analysis; Mutation; Phylogeny; Quorum Sensing / genetics; RNA, Bacterial / genetics
TL;DR:
Investigating whether or not the quorum‐sensing signalling molecule, autoinducer (AI)‐2, was produced by Lactobacillus acidophilus and affected adherence to intestinal epithelial cells found it likely promotes retention in the gastrointestinal tract and communication with the immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 patent
Lactobacillus acidophilus nucleic acids and uses thereof
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus
JOURNAL OF BACTERIOLOGY, 189(13), 4624–4634.
MeSH headings : Bacterial Proteins / genetics; Base Sequence; Bile Acids and Salts / pharmacology; Gene Expression Regulation, Bacterial / drug effects; Gene Order; Genes, Bacterial / genetics; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / drug effects
TL;DR:
Functional analysis of the effects of bile on the global transcriptional profile of lactobacillus acidophilus NCFM showed that the operon encoded proteins involved in both bile tolerance and bile sensitivity, indicating that the 2CRS plays a role in bileolerance and that theOperon it resides in is negatively controlled by the RR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 article
Influence of the dairy environment on gene expression and substrate(1-3)
Klaenhammer, T. R., Azcarate-Peril, M. A., Altermann, E., & Barrangou, R. (2007, March). JOURNAL OF NUTRITION, Vol. 137, pp. 748S–750S.
MeSH headings : Animals; Cattle; Dairy Products; Dairying; Environment; Gene Expression Regulation, Bacterial; Lactobacillaceae / genetics; Lactobacillaceae / metabolism; Probiotics
TL;DR:
Comparative genomics between multiple genomes is providing insights into genes that are important in metabolic, physiological, and functional roles for different LAB in the environments they inhabit, ranging from the gastrointestinal tract to milk and acidified dairy products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(10), 3816–3821.
author keywords: ATP-binding cassette; carbon catabolite repression; fructooligosaccharide; galactoside-pentose hexuronide
MeSH headings : ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Carbohydrate Metabolism / genetics; Gastrointestinal Tract / microbiology; Gene Expression Profiling; Genes, Bacterial; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Models, Biological; Oligonucleotide Array Sequence Analysis; Phosphoenolpyruvate Sugar Phosphotransferase System / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The transport and catabolic machinery involved in carbohydrate utilization by Lactobacillus acidophilus was characterized genetically by using whole-genome cDNA microarrays, and genes central to glycolysis were among the most highly expressed in the genome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Genomic Perspectives on Probiotic Lactic Acid Bacteria
Bioscience and Microflora, 24(2), 31–33.
TL;DR:
The genomic content of probiotic Lactobacillus cultures is examined, compared to those lactic acid bacterial genomes that have appeared recently, to illustrate how environmental conditions encountered during biomanufacturing, fermentation, and the gastrointestinal tract can impact gene expression and culture functionality.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2005 review
Genomic features of lactic acid bacteria effecting bioprocessing and health
[Review of ]. FEMS MICROBIOLOGY REVIEWS, 29(3), 393–409.
author keywords: lactic acid bacteria; genomics; bioprocessing; probiotics; comparative genomics; functional genomics
MeSH headings : Food Microbiology; Genome, Bacterial; Genomics; Health; Humans; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactococcus / genetics; Lactococcus / growth & development; Lactococcus / physiology; Probiotics
TL;DR:
Genomic analyses of multiple members of the lactic acid bacteria have now elucidated many genetic features that direct their fermentative and probiotic roles, providing an important platform for understanding core mechanisms that control and regulate bacterial growth, survival, signaling, and fermentative processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Marker-free chromosomal integration of the manganese superoxide dismutase gene (sodA) from Streptococcus thermophilus into Lactobacillus gasseri
FEMS MICROBIOLOGY LETTERS, 246(1), 91–101.
Contributors: J. Bruno-Bárcena n , n, T. Klaenhammer n & H. Hassan n
author keywords: functional gene replacement; manganese superoxide dismutase; oxidative stress; Lactobacillus gasseri; lactic acid bacteria; probiotics
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / analysis; Chromosomes, Bacterial / genetics; Gene Expression; Hydrogen Peroxide / pharmacology; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Plasmids / genetics; RNA, Bacterial / analysis; RNA, Messenger / analysis; Streptococcus thermophilus / enzymology; Streptococcus thermophilus / genetics; Superoxide Dismutase / genetics; Transformation, Bacterial
TL;DR:
This is the first report showing the successful utilization of the pORI plasmids system to generate marker-free gene integration in L. gasseri strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(9), 5315–5322.
MeSH headings : Base Sequence; Calorimetry; DNA Primers; Genome, Bacterial; Hydrogen-Ion Concentration; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Molecular Sequence Data; Polymerase Chain Reaction; Restriction Mapping
TL;DR:
Interestingly, each integrant also exhibited an adaptive acid response during logarithmic growth, indicating that multiple mechanisms are present and orchestrated in L. acidophilus in response to acid challenge.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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