In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings
BIOMATERIALS, 26(16), 3285–3297.
author keywords: hydrogel; microsphere; controlled drug release; biocompatibility
MeSH headings : Biocompatible Materials / chemistry; Chromatography, High Pressure Liquid; Coated Materials, Biocompatible / chemistry; Dexamethasone / chemistry; Drug Carriers; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Glucocorticoids / chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogels / chemistry; Image Processing, Computer-Assisted; In Vitro Techniques; Kinetics; Lactic Acid / chemistry; Magnetic Resonance Spectroscopy; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microspheres; Models, Chemical; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers / chemistry; Rhodamines / pharmacology; Spectroscopy, Fourier Transform Infrared; Surface Properties; Time Factors; Vascular Endothelial Growth Factor A / chemistry; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
Overall, monolithic, non-degradable hydrogel drug release had an initial burst followed by release at a significantly lower amount, and microsphere drug release kinetics exhibited an initial Burst followed by sustained release for 1 month.
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