Xinhui Lou

Works (8)

Updated: July 5th, 2023 15:57

2019 article

Amplification-by-Polymerization in Biosensing for Human Genomic DNA Detection

He, P., Lou, X., Woody, S. M., & He, L. (2019, April 3). ACS Sensors.

By: P. He n, X. Lou n, S. Woody n & L. He n

author keywords: amplification-by-polymerization; biosensors; genomic DNA detection; RAFT; ATRP
MeSH headings : Biosensing Techniques / methods; Chromosomes, Human, X / chemistry; Chromosomes, Human, Y / chemistry; DNA / blood; DNA / genetics; DNA Probes / chemistry; DNA Probes / genetics; Female; Genomics / methods; Genotype; Humans; Male; Nucleic Acid Hybridization; Photometry / methods; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polymerization; Proof of Concept Study; Sex
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Biosensors and Analytical Detection; Advanced Biosensing Techniques and Applications
TL;DR: The potential of adopting the described sensing technique without PCR was demonstrated, which could further promote the development of a portable, PCR-free DNA sensing device for point-of-need applications. (via Semantic Scholar)
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Source: Web Of Science
Added: June 4, 2019

2007 article

Core−Shell Au Nanoparticle Formation with DNA−Polymer Hybrid Coatings Using Aqueous ATRP

Lou, X., Wang, C., & He, L. (2007, April 28). Biomacromolecules.

By: X. Lou n, C. Wang n & L. He n

MeSH headings : Coated Materials, Biocompatible / chemical synthesis; DNA / chemistry; Electrophoresis; Gold / chemistry; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Polymers / chemistry; Water / chemistry
topics (OpenAlex): Polymer Surface Interaction Studies; Gold and Silver Nanoparticles Synthesis and Applications; Block Copolymer Self-Assembly
TL;DR: A direct surface-grafting approach to forming DNA-containing polymer shells outside of Au nanoparticles using aqueous atom transfer radical polymerization (ATRP) was reported, providing the basis for DNA sensing in homogeneous solutions. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

Surface passivation using oligo(ethylene glycol) in ATRP-assisted DNA detection

Lou, X., & He, L. (2007, August 7). Sensors and Actuators B Chemical.

By: X. Lou n & L. He n

author keywords: surface passivation; oligo(ethylene glycol); self-assembled monolayer; DNA sensing
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Molecular Junctions and Nanostructures; Analytical Chemistry and Sensors
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Source: Web Of Science
Added: August 6, 2018

2006 article

DNA-Accelerated Atom Transfer Radical Polymerization on a Gold Surface

Lou, X., & He, L. (2006, February 17). Langmuir.

By: X. Lou n & L. He n

MeSH headings : Base Sequence; DNA, Single-Stranded / chemistry; Gold / chemistry; Nuclear Magnetic Resonance, Biomolecular
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Polymer Surface Interaction Studies; DNA and Nucleic Acid Chemistry
TL;DR: The results show that the presence of DNA molecules, although at a less-than-1% surface coverage, significantly accelerated the growth rates of both poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(oligoethylene glycol methacries) (POEGMA) at the beginning of the ATRP reactions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 article

Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents

Zhang, Y., Ballard, C. E., Zheng, S.-L., Gao, X., Ko, K.-C., Yang, H., … Wang, B. (2006, November 3). Bioorganic & Medicinal Chemistry Letters.

By: Y. Zhang *, C. Ballard n, S. Zheng *, X. Gao*, K. Ko*, H. Yang*, G. Brandt*, X. Lou n ...

author keywords: design; synthesis; efflux substrate-metal chelator conjugates; antimicrobial agents
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Bacillus subtilis / drug effects; Bacteria / drug effects; Bacteria / metabolism; Chelating Agents / chemical synthesis; Chelating Agents / pharmacology; Drug Design; Drug Resistance, Multiple, Bacterial; Escherichia coli / drug effects; Indicators and Reagents; Metals / metabolism; Microbial Sensitivity Tests; Structure-Activity Relationship
topics (OpenAlex): Synthesis and Biological Evaluation; Metal complexes synthesis and properties; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to achieve bacterial killing were designed and synthesized. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Radical polymerization in biosensing

Lou, X., He, P., Okelo, G. O., & He, L. (2006, July 18). Analytical and Bioanalytical Chemistry.

By: X. Lou n, P. He n, G. Okelo n & L. He n

author keywords: free radical polymerization; controlled; living radical polymerization; biosensors; biosensing
MeSH headings : Artifacts; Biosensing Techniques / methods; Free Radicals; Polymers; Surface Properties
topics (OpenAlex): Analytical Chemistry and Sensors; Conducting polymers and applications; Luminescence and Fluorescent Materials
TL;DR: Advancements in surface modification aimed at improving sensor biocompatibility and reducing nonspecific background noises are discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Detection of DNA Point Mutation by Atom Transfer Radical Polymerization

Lou, X., Lewis, M. S., Gorman, C. B., & He, L. (2005, July 7). Analytical Chemistry, Vol. 77, pp. 4698–4705.

By: X. Lou n, M. Lewis n, C. Gorman n  & L. He n

Contributors: X. Lou n, M. Lewis n, C. Gorman n  & . al.

MeSH headings : DNA / analysis; DNA / genetics; DNA / ultrastructure; Free Radicals / chemistry; Microscopy, Atomic Force; Molecular Structure; Point Mutation / genetics; Polyhydroxyethyl Methacrylate / chemistry; Spectrum Analysis
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; DNA and Nucleic Acid Chemistry; Microfluidic and Capillary Electrophoresis Applications
TL;DR: A new DNA detection method in which polymer growth in atom transfer radical polymerization (ATRP) is used as a means to amplify detection signals and laid the groundwork for the future development of detector-free testing kits in single-nucleotide polymorphism screenings. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Barcoding the microworld

Analytical Chemistry, 76(19), 353A–359.

By: N. Finkel, X. Lou, C. Wang & L. He

Source: NC State University Libraries
Added: August 6, 2018

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