Xinhui Lou

Works (8)

Updated: July 5th, 2023 15:57

2019 journal article

Amplification-by-Polymerization in Biosensing for Human Genomic DNA Detection

ACS SENSORS, 4(4), 992–1000.

By: P. He n, X. Lou n, S. Woody n & L. He n

author keywords: amplification-by-polymerization; biosensors; genomic DNA detection; RAFT; ATRP
MeSH headings : Biosensing Techniques / methods; Chromosomes, Human, X / chemistry; Chromosomes, Human, Y / chemistry; DNA / blood; DNA / genetics; DNA Probes / chemistry; DNA Probes / genetics; Female; Genomics / methods; Genotype; Humans; Male; Nucleic Acid Hybridization; Photometry / methods; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polymerization; Proof of Concept Study; Sex
TL;DR: The potential of adopting the described sensing technique without PCR was demonstrated, which could further promote the development of a portable, PCR-free DNA sensing device for point-of-need applications. (via Semantic Scholar)
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Source: Web Of Science
Added: June 4, 2019

2007 journal article

Core-shell Au nanoparticle formation with DNA-polymer hybrid coatings using aqueous ATRP

BIOMACROMOLECULES, 8(5), 1385–1390.

By: X. Lou n, C. Wang n & L. He n

MeSH headings : Coated Materials, Biocompatible / chemical synthesis; DNA / chemistry; Electrophoresis; Gold / chemistry; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Polymers / chemistry; Water / chemistry
TL;DR: A direct surface-grafting approach to forming DNA-containing polymer shells outside of Au nanoparticles using aqueous atom transfer radical polymerization (ATRP) was reported, providing the basis for DNA sensing in homogeneous solutions. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Surface passivation using oligo(ethylene glycol) in ATRP-assisted DNA detection

SENSORS AND ACTUATORS B-CHEMICAL, 129(1), 225–230.

By: X. Lou n & L. He n

author keywords: surface passivation; oligo(ethylene glycol); self-assembled monolayer; DNA sensing
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

DNA-accelerated atom transfer radical polymerization on a gold surface

LANGMUIR, 22(6), 2640–2646.

By: X. Lou n & L. He n

MeSH headings : Base Sequence; DNA, Single-Stranded / chemistry; Gold / chemistry; Nuclear Magnetic Resonance, Biomolecular
TL;DR: The results show that the presence of DNA molecules, although at a less-than-1% surface coverage, significantly accelerated the growth rates of both poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(oligoethylene glycol methacries) (POEGMA) at the beginning of the ATRP reactions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Design, synthesis, and evaluation of efflux substrate-metal chelator conjugates as potential antimicrobial agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(3), 707–711.

By: Y. Zheng *, C. Ballard n, S. Zheng, X. Gao*, K. Ko*, H. Yang*, G. Brandt*, X. Lou n ...

author keywords: design; synthesis; efflux substrate-metal chelator conjugates; antimicrobial agents
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Bacillus subtilis / drug effects; Bacteria / drug effects; Bacteria / metabolism; Chelating Agents / chemical synthesis; Chelating Agents / pharmacology; Drug Design; Drug Resistance, Multiple, Bacterial; Escherichia coli / drug effects; Indicators and Reagents; Metals / metabolism; Microbial Sensitivity Tests; Structure-Activity Relationship
TL;DR: A series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to achieve bacterial killing were designed and synthesized. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 review

Radical polymerization in biosensing

[Review of ]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 386(3), 525–531.

By: X. Lou n, P. He n, G. Okelo n & L. He n

author keywords: free radical polymerization; controlled; living radical polymerization; biosensors; biosensing
MeSH headings : Artifacts; Biosensing Techniques / methods; Free Radicals; Polymers; Surface Properties
TL;DR: Advancements in surface modification aimed at improving sensor biocompatibility and reducing nonspecific background noises are discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 journal article

Detection of DNA point mutation by atom transfer radical polymerization

ANALYTICAL CHEMISTRY, 77(15), 4698–4705.

By: X. Lou n, M. Lewis n, C. Gorman n  & L. He n

Contributors: X. Lou n, M. Lewis n, C. Gorman n  & . al.

MeSH headings : DNA / analysis; DNA / genetics; DNA / ultrastructure; Free Radicals / chemistry; Microscopy, Atomic Force; Molecular Structure; Point Mutation / genetics; Polyhydroxyethyl Methacrylate / chemistry; Spectrum Analysis
TL;DR: A new DNA detection method in which polymer growth in atom transfer radical polymerization (ATRP) is used as a means to amplify detection signals and laid the groundwork for the future development of detector-free testing kits in single-nucleotide polymorphism screenings. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Barcoding the microworld

Analytical Chemistry, 76(19), 353A–359.

By: N. Finkel, X. Lou, C. Wang & L. He

Source: NC State University Libraries
Added: August 6, 2018

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