Jennifer M. Carrozzino

Works (2)

Updated: July 5th, 2023 15:57

2005 article

pH effects on drug interactions with lipid bilayers by liposome electrokinetic chromatography

Carrozzino, J. M., & Khaledi, M. G. (2005, May 11). Journal of Chromatography A.

By: J. Carrozzino n & M. Khaledi n

author keywords: liposome electrokinetic chromatography; drug; lipid bilayers; partition coefficient; lipophilicity; passive transmembrane permeability; caco-2 cell permeability; oral bioavailability
MeSH headings : Caco-2 Cells; Electrophoresis, Capillary / methods; Humans; Hydrogen-Ion Concentration; Lipid Bilayers / metabolism; Liposomes / chemistry; Pharmaceutical Preparations / metabolism
topics (OpenAlex): Lipid Membrane Structure and Behavior; Microfluidic and Capillary Electrophoresis Applications; Analytical Chemistry and Chromatography
TL;DR: The effects of pH on the partitioning of basic drugs into liposomes composed of zwitterionic phosphatidylcholine, anionic phosph atidylglycerol, and cholesterol, which mimic the composition of natural cell membranes, were determined. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Interaction of Basic Drugs with Lipid Bilayers Using Liposome Electrokinetic Chromatography

Carrozzino, J. M., & Khaledi, M. G. (2004, December 1). Pharmaceutical Research.

By: J. Carrozzino n & M. Khaledi n

author keywords: basic drugs; liposomes; octanol; partitioning
MeSH headings : Chromatography, Micellar Electrokinetic Capillary / methods; Hydrogen-Ion Concentration; Lipid Bilayers / analysis; Lipid Bilayers / metabolism; Liposomes; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism
topics (OpenAlex): Lipid Membrane Structure and Behavior; Analytical Chemistry and Chromatography; Microfluidic and Capillary Electrophoresis Applications
TL;DR: These studies demonstrate the overall buffer ionic strength at a given pH is more important than buffer type and concentration, and the interaction of positively charged drugs with charged lipid bilayer membranes is selectively influenced by the pKa of the drug. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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