Works (2)
Updated: July 5th, 2023 15:57
2005 journal article
PH effects on drug interactions with lipid bilayers by liposome electrokinetic chromatography
JOURNAL OF CHROMATOGRAPHY A, 1079(1-2), 307–316.
author keywords: liposome electrokinetic chromatography; drug; lipid bilayers; partition coefficient; lipophilicity; passive transmembrane permeability; caco-2 cell permeability; oral bioavailability
MeSH headings : Caco-2 Cells; Electrophoresis, Capillary / methods; Humans; Hydrogen-Ion Concentration; Lipid Bilayers / metabolism; Liposomes / chemistry; Pharmaceutical Preparations / metabolism
TL;DR:
The effects of pH on the partitioning of basic drugs into liposomes composed of zwitterionic phosphatidylcholine, anionic phosph atidylglycerol, and cholesterol, which mimic the composition of natural cell membranes, were determined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Interaction of basic drugs with lipid bilayers using liposome electrokinetic chromatography
PHARMACEUTICAL RESEARCH, 21(12), 2327–2335.
author keywords: basic drugs; liposomes; octanol; partitioning
MeSH headings : Chromatography, Micellar Electrokinetic Capillary / methods; Hydrogen-Ion Concentration; Lipid Bilayers / analysis; Lipid Bilayers / metabolism; Liposomes; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism
TL;DR:
These studies demonstrate the overall buffer ionic strength at a given pH is more important than buffer type and concentration, and the interaction of positively charged drugs with charged lipid bilayer membranes is selectively influenced by the pKa of the drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018